Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
DAVID S HONG · MAINSQUARE CO · 2024 · $424,754 — Abstract – MainSquare Co. (dba “Teleo”) is developing a HIPAA-compliant virtual therapy room for children that transforms how clinicians deliver psychotherapy to children remotely, improving client engagement over standard video conferencing platforms (e.g., Zoom). One in 5 children have a mental he…
Christina U Lorentz · ARONORA, INC. · 2024 · $493,999 — Project Summary Indwelling central venous catheters (CVCs), including peripherally inserted central catheters (PICCs) as well as implantable venous access ports, are commonly used for drug treatments or supportive care in a variety of disease conditions; however, central lines carry a risk of compli…
Daniel F Dwyer · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $715,968 — Project Summary/Abstract: Mast cells (MCs) expand within the airway epithelium and sub-epithelium during prevalent and burdensome human respiratory disease, including asthma and nasal polyposis, where they are thought to play a central role in disease pathobiology. MCs take on discrete protease expr…
Dayu Lin · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $709,362 — SUMMARY STATEMENT Parental care is an innate social behavior essential for species survival. Hence, a hardwired circuit has evolved to support its expression. However, naïve animals often show hostile behaviors toward infants, including infanticide. These are thought to be selected to free up resour…
CHRISTINE M Lee · UNIVERSITY OF WASHINGTON · 2024 · $311,000 — ABSTRACT Cannabis is a widely used psychoactive substance among young adults (YAs), with ~44% using in the past year. Daily use by YAs not attending college (14.5%) is 3x the prevalence of daily use by college attending peers (4.7%). Cannabis is associated with acute and longer-term consequences. A …
Melanie M Pina · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $76,809 — Project Summary Repeated episodes of binge alcohol drinking dysregulate serotonin (5-hydroxytryptamine, 5-HT) systems throughout the brain, which may place an individual at greater risk of developing an alcohol use disorder (AUD). The orbitofrontal cortex (OFC) is one site of 5-HT innervation that h…
marty schultz · OBJECTIVE ED, INC. · 2024 · $55,000 — Summary: Our Phase I prototype, College Readiness Stories (CRS) will be based on our innovative process that captures the knowledge and best practices from research scientists, practicing counselors, and successful adults with the disability and encodes their experience into a human-computer interac…
MAX S. WICHA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $474,547 — PROJECT SUMMARY/ABSTRACT Triple negative breast cancer (TNBC) is the most aggressive subtype with increased propensity for metastasis and few treatment options. Mounting evidence suggests that cancer stem-like cells (CSCs) in TNBC contribute to the early recurrence and poor clinical outcomes. Thus, …
David Gius · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $144,601 — SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disruption of cell metabolism leads to accumulation of reactive oxygen species (ROS) and triggers maladaptive signaling that…
DAQING WU · CLARK ATLANTA UNIVERSITY · 2024 · $56,208 — Docetaxel is the first-line chemotherapy for metastatic castration-resistant prostate cancer (PCa), the major cause of PCa mortality. Unfortunately, in most cases PCa develops docetaxel resistance and continues to progress, which has no cure. Our recent studies (Theranostics, 2021, May 8; 11: 6873-6…
Troy E Messick · WISTAR INSTITUTE · 2024 · $128,992 — Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously treat EBV-positive tumors. All known EBV tumors consistently express one viral nuclear protein, EBNA1, that is required for…
Lauren E McCullough · EMORY UNIVERSITY · 2024 · $127,147 — PROJECT SUMMARY/ABSTRACT Significance. Although national and philanthropic efforts have sought to reduce and eliminate breast cancer (BC) mortality disparities over the past few decades, they have not only persisted—but widened. Additionally, due to incomplete capture of recurrence data, no previous…
Frank Pajonk · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $102,267 — SUMMARY/ABSTRACT Despite a tremendous effort in basic science, clinical trials, drug development, and technical advances in surgery and radiation oncology, glioblastoma remains incurable and improvements in overall survival have been marginal. While radiotherapy is still one of the most effective tr…
Dawn S Chandler · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $63,326 — ABSTRACT Tumor suppressor p53 is the quintessential guardian of the genome whose function is inhibited in greater than 50% of all human cancers. Though mutation and deletion of p53 are major contributors to p53 inactivation, overexpression of the negative regulators MDM2 and MDM4 (MDMX) are also kno…
Erin Lynn Van Blarigan · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $129,491 — Colorectal cancer (CRC) is the 2nd leading cause of cancer death in the United States. The American Cancer Society (ACS) recommends normal body mass index (BMI), regular physical activity, and a healthy diet for cancer survivors. In 2018, we estimated that 38% of deaths within 5 years of diagnosis c…
Alice Berger · FRED HUTCHINSON CANCER CENTER · 2024 · $129,789 — PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have revolutionized lung cancer clinical practice. Lung adenocarcinomas harbor frequent mutations/amplifications/fusions in receptor tyrosine kinase (RTK) and RAS pathway oncogenes, many of which can be targeted by FDA-approved therapies…
William Alexis Calo · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $63,731 — ABSTRACT Despite the availability of the human papillomavirus (HPV) vaccine that can prevent over 34,800 HPV-related cancers in the US every year, only 51% of girls and boys were up-to-date by 2018. Rural populations are the most impacted by HPV-related cancers. Best practices like the Announcement …
Randall J. Kimple · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $71,347 — Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. These models are established using patient tumors sourced from surgical specimens and typically implanted into the subcutaneous tissue of the mouse. There is …
Aiming Yu · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $394,349 — PROJECT SUMMARY Lung cancer remains the most lethal cancer among both women and men in the United States. There is a clear need for developing new and more effective therapeutics for the treatment of lung cancer, especially the most predominant subtype non-small cell lung cancer (NSCLC). As posttran…
Lauren Elizabeth Ball · DREXEL UNIVERSITY · 2024 · $74,294 — Project Summary It is widely accepted that tumors are highly heterogeneous. There is a subpopulation of cells in a tumor, called tumor-initiating cell, that can be isolated and are able to self-renew, differentiate and form the bulk of the tumor. Many cancers don't respond to traditional chemothera…