Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Whitney Christine Barnett · VANDERBILT UNIVERSITY · 2024 · $35,791 — PROJECT SUMMARY The goal of this career development award is to support Dr. Whitney Barnett in developing an independent research program focused on public health interventions to prevent child maltreatment (CM). Given the significant impact of CM on both short and long-term health, it is critical …
Christian R Salazar · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $137,092 — Project Summary Despite longstanding efforts to improve recruitment of minorities into Alzheimer’s Disease and Related Dementias (ADRD) research, US Hispanics/Latinos continue to be severely underrepresented in ADRD randomized clinical trials. Greater representation of Hispanics/Latinos is critical …
Silvia N Moreno · UNIVERSITY OF GEORGIA · 2024 · $431,149 — PROJECT SUMMARY/ABSTRACT Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. The phylum member Toxoplasma gondii alone infects approximately one third of the world population. T. gondii is an opportunisti…
Liang Gao · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $495,587 — Project Summary: Atrial fibrillation (AF) is the most frequent cardiac arrhythmia, and it is a major risk factor for ischemic stroke and provokes morbidity and mortality along with a significant economic burden. Although AF has been studied in various animals, the embryonic zebrafish has been the ge…
Margaret B Conroy · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $558,388 — ABSTRACT Obesity is a major health problem in the United States and associated with increased risk of diabetes. There is a great need for interventions that can assist with long-term maintenance of healthy body weight and be sustainably integrated into existing health care teams. We have developed a…
NINGLING KANG · UNIVERSITY OF MINNESOTA · 2024 · $358,744 — The development of liver metastasis is dependent upon bidirectional interactions between cancer cells and the liver microenvironment. Transforming growth factor beta (TGFβ), released from cancer cells and other resident liver cells, induces activation of hepatic stellate cells (HSCs) into myofibrobl…
Chuanju Liu · YALE UNIVERSITY · 2024 · $388,041 — Project Summary Pro-inflammatory cytokine TNFα is believed to be responsible for the delayed fracture healing observed in diabetes. However, there is no consensus on the effect of TNFα inhibition on the bone formation, indicating the unmet need in searching for new regents with unique features othe…
EMMANUEL O AKALA · HOWARD UNIVERSITY · 2024 · $154,500 — Project Summary: Triple-negative breast cancer (TNBC) accounts for approximately 15% of invasive breast cancers and is associated with aggressive tumor biology, poor prognosis, resistance, visceral metastases and earlier disease recurrence. TNBC is more common in younger women than in older women an…
Zhen Fan · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $564,306 — PROJECT SUMMARY The overall goal of this project is to improve activities of therapeutic antibodies against cancer metastasis through developing novel bispecific antibodies (BsAbs). The central hypothesis of this project is that BsAbs designed with one specificity for a receptor or marker overexpres…
Ye Zheng · SALK INSTITUTE FOR BIOLOGICAL STUDIES · 2024 · $237,500 — PROJECT SUMMARY Regulatory T cells (Treg) play a crucial role in keeping the immune system in balance and preventing autoimmune disease. Defective Treg function leads to autoimmune diseases, while intra-tumor Tregs can block effective anti-tumor immune responses. Tregs can undergo further specializa…
Paramita M. Ghosh · VA NORTHERN CALIFORNIA HEALTH CARE SYS · 2024 — SUMMARY: Treatment patterns for metastatic castration-resistant prostate cancer (mCRPC) at the US Veterans Health Administration (VHA) have changed substantially in the past few years. VHA patients with mCRPC are still treated with androgen deprivation therapy (ADT) with luteinizing hormone releasin…
Joycelyn Lawrence · UNIVERSITY OF MIAMI CORAL GABLES · 2024 · $860,545 — Implementation of a Comprehensive Survivorship Care Intervention Across FQHC-Based Primary Care Practices PROJECT SUMMARY Cancer survivorship challenges adversely contribute to cancer burden, morbidity and mortality, and are exacerbated by multiple health care and contextual barriers such as oncolog…
Jiaxin Liang · DANA-FARBER CANCER INST · 2024 · $128,798 — Project Summary: Immunotherapies have revolutionized the clinical treatment of melanoma; however, these treatment strategies have been ineffective in treating late stage and metastatic melanoma lesions with overall patient response rates below 50% illustrating an unmet medical need in melanoma thera…
REGAN BAILEY · TEXAS A&M AGRILIFE RESEARCH · 2024 · $281,646 — PROJECT SUMMARY Dietary indices and scores provide a comprehensive and robust approach for nutritional exposure assessment, especially in relation to chronic disease risk. While dietary supplement (DS) use is very common among the U.S. population, with over 52% of adults and 33% of children routinel…
Miguel Angel Cruz · BAYLOR COLLEGE OF MEDICINE · 2024 · $464,096 — A major complication of mechanical circulatory support devices (MCSD) for multi-organ support is the dichotomous pathology of thrombosis and bleeding. Intravascular hemolysis associated with MCSD produces free hemoglobin (fHb). Adsorption of fibrinogen and von Willebrand factor (VWF) onto non-biolog…
Nancy Chia Lei Jao · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · 2024 · $177,714 — PROJECT SUMMARY/ABSTRACT The proposed K01 application is designed to provide Nancy Jao, Ph.D., with the mentored research and training necessary to transition into an independent clinical scientist with a tobacco regulatory relevant program of research. The FDA has long indicated interest in banning…
Lark L Coffey · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $199,187 — PROJECT ABSTRACT St. Louis encephalitis virus (SLEV) is a re-emerging mosquito-borne flavivirus that causes a spectrum of manifestations in people ranging from febrile illness to encephalitis and death. Clinical disease caused by SLEV is indistinguishable from related West Nile virus (WNV). Although…
Ju Chen · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $521,263 — PROJECT SUMMARY Mutations in genes encoding nuclear envelope (NE) components cause an array of diseases referred to as nuclear envelopathies that often manifest as cardiomyopathies. The NE separates the nucleoplasm from cytoplasm and is composed of outer and inner nuclear membranes. The nuclear lami…
John Koethe · GHESKIO CENTER · 2024 · $168,145 — ABSTRACT Haiti has the largest number of persons with HIV (PWH) in the Caribbean. PWH have a higher risk of developing metabolic and cardiovascular disease (CVD), which are leading causes of mortality among Haitians and other residents of low and middle-income countries (LMICs), driven in part by hi…
Jariel Yamil Ramirez-Virella · MICHIGAN STATE UNIVERSITY · 2024 · $40,506 — Project Summary Overconsumption of food and reduced physical activity cause obesity, but limited understanding of the neuronal systems regulating these behaviors has hindered development of therapies to support weight loss. Intriguingly, injecting the neuropeptide neurotensin (Nts) into the ventral…