Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Carlton Adams · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $48,974 — Project Summary Legionella pneumophila (Lp) is the agent of Legionnaires' disease, an oft-fatal pneumonia that is increasing in incidence. Lp is ubiquitous in water systems, infecting the lungs after inhalation of contaminated droplets. In waters, Lp persists as an intracellular parasite of amoebae …
Christine M Constantinople · NEW YORK UNIVERSITY · 2024 · $337,222 — A key computation that all mammals perform is determining the value of different outcomes. People and animal models evaluate outcomes as gains or losses relative to an internal reference point, likely reflecting their experience-based expectations. For example, if someone is told they will receive …
Neelanjan Mukherjee · UNIVERSITY OF COLORADO DENVER · 2024 · $388,750 — SUMMARY Cellular responses to external stimuli require dynamic gene regulation to facilitate rapid activation and effective resolution. Although transcriptional responses are a textbook mechanism for stimulus-induced responses, post- transcriptional regulation of mRNA translation and decay are the o…
Theodore Paul Braun · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $488,445 — PROJECT SUMMARY/ABSTRACT Kinase inhibitor therapy has made a minimal impact on the clinical treatment of patients with Acute Myeloid Leukemia (AML). We have shown that inhibition of the epigenetic regulator lysine-specific demethylase 1 (LSD1) augments the efficacy of kinase inhibition in AML, inclu…
David R. Linden · MAYO CLINIC ROCHESTER · 2024 · $538,004 — Project Summary / Abstract The gastrointestinal (GI) tract is the only organ system that is capable of intrinsic neural reflexes. These are initiated by a unique neuron type called intrinsic primary afferent neurons (IPANs). IPANs are key to orchestrating neural reflexes that allow efficient process…
Keith D Robertson · MAYO CLINIC ROCHESTER · 2024 · $226,364 — ABSTRACT Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers and is the 8th leading cause of cancer death in the United States. In addition to near ubiquitous loss of VHL, the landscape of ccRCC is dominated by mutations in epigenetic regulators SETD2, PBRM1, and BAP1. The e…
Kelsey Marie Tyssowski · HARVARD UNIVERSITY · 2024 · $130,815 — PROJECT SUMMARY The goal of the proposed research is to discover how variation in the number of corticospinal neurons (CSNs) causes variation in motor circuit function and dexterous behavior, thus linking cells, circuits, and behavior in the same system. The evolution of advanced cognitive and motor…
Wouter Meuleman · ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES · 2024 · $369,847 — PROJECT SUMMARY The human genome contains the structural and operational instructions for living cells, yet exactly what these instructions are and how they are utilized and encoded in the primary genomic sequence is poorly understood. Arguably the only well-understood portions of the genome are pro…
Frances Rudnick Levin · PHOENIX PHARMALABS, INC. · 2024 · $3,623,079 — Abstract Currently, clinically used drug abuse medications exist for treatment of addiction to opiates, alcohol, and nicotine, but not psychostimulants such as cocaine and methamphetamine (METH). PPL-138 is a non-selective opioid receptor ligand with partial agonist activity at NOP and mu receptors,…
Anita K. Patel · CHILDREN'S RESEARCH INSTITUTE · 2024 · $151,595 — PROJECT ABSTRACT Iatrogenic withdrawal affects up to 57% of children who receive sedative and analgesic medications in the pediatric intensive care unit (ICU), contributing to delayed recovery, patient and parental distress and prolonged hospitalization in (an estimated) 70,000 children per year. Du…
Kelsie Marie Full · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $120,177 — PROJECT SUMMARY. Alzheimer’s disease and related dementias (ADRD) has become a major public health crisis. To date, therapeutic strategies for Alzheimer’s disease have been largely ineffective resulting in an increased focus on identifying effective prevention strategies. Daily 24-hour activity beha…
Kevin D Phelan · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $241,655 — Arkansas Technology and Data Science in Health and medicine (AR Tech-DaSH) is a partnership between the University of Arkansas for Medical Sciences (UAMS) and high school students and teachers primarily in northwest (NW) Arkansas. The program targets the underserved and underrepresented population o…
Kimberly Jean Vish · YALE UNIVERSITY · 2024 · $48,974 — Project Summary/Abstract The EphB4-p120RasGAP signaling axis is critical for vascular development and mutations in both EphB4 and p120RasGAP are associated with vascular disorders including Vein of Galen Malformation (VOGM) and Capillary Malformation-Arteriovenous Malformation (CM-AVM) Syndrome. One…
Jonathan Joseph Edwards · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $131,400 — ABSTRACT The proposal in this application outlines a five-year career development plan to prepare the candidate, Dr. Jonathan Edwards, MD, for a career as an independent physician-scientist defining mechanisms of right ventricular failure (RVF). The research and development plans are carefully struc…
Benjamin L Brett · MEDICAL COLLEGE OF WISCONSIN · 2024 · $132,171 — Project Summary/Abstract (1 page) Exposure to mild traumatic brain injury (mTBI) and repetitive head impacts (RHI) during sport participation has been associated with adverse long-term consequences (e.g., cognitive decline). Research investigating these associations has been limited to cross-section…
Bryant Oliphant · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $93,758 — Project Summary More than 345,000 patients are treated for a lower extremity injury (LEI) each year at trauma centers (TC) in the United States. This represents a substantial societal burden both in the direct treatment costs and the indirect costs due to lost work. These injuries are often painful,…
Simon Cornelis Groen · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2024 · $378,974 — ABSTRACT There are fundamental gaps in our understanding of how genome-wide functional genetic variation in host-parasite interactions is shaped by natural selection, including for humans. Parasitic helminths (including nematodes) present important selective agents on host traits and underlying gene…
Jacqueline Linnes · PURDUE UNIVERSITY · 2024 · $392,991 — SUMMARY ABSTRACT Although cervical cancer is an easily curable disease if detected early, it continues to claim the lives of hundreds of thousands of women worldwide. Healthcare disparities have resulted in cervical cancer incidence and mortality that are five times higher in low and middle income …
Erik Rytting · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $237,920 — PROJECT SUMMARY/ABSTRACT Ulcerative Colitis (UC) and Crohn’s disease (CD), the two major types of inflammatory bowel disease (IBD), are chronic diseases with recurrent symptoms and significant morbidity. There exists a lack of efficient medications for IBD, primarily due to either limited efficacy o…
Cole A DeForest · UNIVERSITY OF WASHINGTON · 2024 · $428,361 — PROJECT SUMMARY Despite innovations in diagnosis and treatment, colorectal cancer (CRC) remains one the most common causes of cancer-related deaths in the United States. During tumorigenesis, the extracellular matrix (ECM) drastically stiffens, resulting in a self-amplifying feedback loop, furtherin…