Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Basak Icli · TUFTS MEDICAL CENTER · 2024 · $598,681 — PROJECT SUMMARY/ABSTRACT White and brown adipose tissues are highly vascularized organs, capable of plasticity based on metabolic demands and energy expenditure. However maladaptive regulation of these tissues can lead to insulin resistance. Critical gaps remain in our understanding of how angiogen…
Monica Shokeen · WASHINGTON UNIVERSITY · 2024 · $592,217 — Multiple myeloma (MM) is the 2nd most common, age related, hematological malignancy with an estimated 30,000 new cases and 13,000 deaths per year. Patients with upfront refractory disease progress fast, and those that enter remission eventually die as a consequence of relapsed disease. To increase p…
Brian Joseph Beliveau · UNIVERSITY OF WASHINGTON · 2024 · $31,901 — Project Summary Mammalian cells package two meters of linear DNA into a nucleus whose diameter is on average only a few microns. This packaging must be done in such a way that DNA transactions such as transcription, replication, and repair can faithfully occur. The development of the `Hi-C' techniqu…
Lars Benner · JOHNS HOPKINS UNIVERSITY · 2024 · $48,974 — Project Summary The molecular characterization of sex-specific piRNA transcription and snRNA transcription in C. elegans. PIWI-interacting RNAs (piRNAs) play key roles in repressing transposons in the germline. Loss of transposon- targeting piRNAs can have sex-specific consequences leading to genomi…
Taniel Solarnge Winner · EMORY UNIVERSITY · 2024 · $23,079 — PROJECT SUMMARY/ABSTRACT Stroke gait deficits are complex and marked by adverse effects on kinematics, kinetics, gait symmetry, and inter- and intra- limb joint coordination across different phases of the gait cycle. One intervention simply cannot target the high inter-individual variability of defi…
Neal A. DeLuca · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $273,221 — Project Summary Viruses have evolved a vast array of mechanisms to avoid detection and/or elimination by host defenses and to establish persistent infections that not only ensures survival in the human population, but can also contribute to pathogenesis. While we have developed effective antiviral …
SAMIE R JAFFREY · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $1,052,256 — The overall goal of our research program is to understand the intricate mechanisms by which neurons establish the precise spatial and patterns of protein synthesis needed for synaptic plasticity and circuit formation. Much of this regulation occurs at the RNA level, and my laboratory focuses on unco…
Zhen Yan · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $414,641 — PROJECT SUMMARY/ABSTRACT Regular exercise promotes physical performance and health, and prevent various types of diseases. These benefits are largely mediated by responses and adaptations, particularly mitochondrial remodeling, in skeletal muscle. 5' AMP-activated protein kinase (AMPK) is a bioener…
DeAnalisa Jones · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $47,211 — PROJECT SUMMARY Sudden cardiac death (SCD) is estimated to cause 4-5 million deaths per year worldwide. In patients with heart failure, SCD is the number one leading cause of death and is linked to the onset of ventricular arrhythmias. Understanding how ventricular arrhythmias arise in patients with…
Jiajie Diao · UNIVERSITY OF CINCINNATI · 2024 · $405,000 — PROJECT SUMMARY Autophagy is a crucial catabolic pathway by which cellular waste is recycled. Autophagic dysfunction has been implicated in cellular quality control, responses to stress, development, lifespan, and a range of infectious and other diseases in humans, including cancer, neurodegenerativ…
John A. Tainer · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $828,132 — PROJECT SUMMARY/ABSTRACT Cancer is linked to almost every human DNA repair (DR) pathway. Genomic instability, which results from DR defects, is a cancer hallmark. Thus, DNA damaging cancer therapies are widely used and are often successful. Yet, the effects of DNA damage depend on poorly understood …
Jered C Garrison · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $621,119 — ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a lethal, treatment-refractory malignancy characterized by fibroblast-rich stroma. While external beam radiation therapy (EBRT) is a staple in the current treatment of PDAC, its therapeutic efficacy is limited by normal tissue toxicities and its i…
Carolyn Audet · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $1,134,775 — Project Summary Human Immunodeficiency Virus (HIV) infection remains a significant public health problem in the United States (US). It is estimated that almost 15% of the 1.17 million people living with HIV (PLWH) in the US are unaware of their HIV status. And despite the existence of highly effecti…
JEANNE-MARIE GUISE · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $999,286 — Overall Project Summary Never in our lifetimes has there been a greater collective focus on health or the need to address the wide disparities we face as a country in health outcomes. The Massachusetts Institute for Equity-Focused Learning Health System Science (MIELHSS) brings together an alliance …
Lana Z Alagha · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · 2024 · $999,455 — RESEARCH PLAN – ABSTRACT This proposal will advance research, technological and other interventions, and training programs to empower miners for safe self-escape in mine emergencies. It will 1) advance research in underground wireless communication; 2) study human-robot interactions for safe miner s…
Jaime Peterson · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $151,299 — PROJECT SUMMARY Children who enter school ready to learn are more likely to succeed academically. Yet, low-income children often enter school behind their more affluent peers. The growing population of Latino children experience economic and cultural barriers to school readiness (SR). The primary ca…
Jomella Thompson · UNIVERSITY OF KANSAS LAWRENCE · 2024 · $1,199,995 — Project Abstract Summary Youth violence is a critical public health concern. In 2019, there were 46.9 homicides per 100,000 for youth ages 10 to 24 in the Kansas City (KC) metro area compared to 7.82 in the U.S. overall. Youth homicide is the third leading cause of death for individuals 15 to 24 ye…
Elizabeth Compton Bowdridge · WEST VIRGINIA UNIVERSITY · 2024 · $108,000 — PROJECT SUMMARY Elizabeth Bowdridge, Ph.D., is a reproductive toxicologist whose overarching career goal is to establish a successful laboratory focused on the effects of occupational and environmental factors on microvascular adaptations during gestation that ultimately impact fetal outcomes. Her p…
Michael Klompas · HARVARD PILGRIM HEALTH CARE, INC. · 2024 · $462,347 — PROJECT ABSTRACT Sepsis is a leading cause of death. It is also a major driver of antibiotic utilization, in large part because current guidelines and mandates compel clinicians to administer antibiotics immediately for all patients with possible sepsis even though more than a third of patients ini…
Sharon Hewner · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2024 · $379,673 — Abstract: Coordinating transitional care for high-need/high-cost patients (HNHC); those with multiple chronic or complex chronic conditions, functional disabilities and/or social needs; often requires collaboration with service partners outside the health care sector. To improve care for HNHC patien…