Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Shi-Yong Sun · EMORY UNIVERSITY · 2024 · $474,087 — SUMMARY Epidermal growth factor receptor (EGFR)-targeted therapy with EGFR tyrosine kinase inhibitors (EGFR-TKIs), particularly current third generation mutation-selective agents such as osimertinib (AZD9291 or TAGRISSOTM), has achieved great success and provided significant clinical benefit in pati…
Even Paglisotti · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $38,151 — PROJECT SUMMARY PAR-22-172 Mental Health Research Dissertation Grant to Enhance Workforce Diversity (R36): Transgender and/or nonbinary (TNB) college students (those whose gender is incongruent with their sex assigned at birth) are at substantially higher risk for mental health concerns (e.g. suicid…
Tyler Pikes · PURDUE UNIVERSITY · 2024 · $48,974 — PROJECT SUMMARY Neutrophils are white blood cells involved in the innate immune response. They are the most abundant white blood cell in circulation and are involved in fighting infections as well as initiating inflammatory immune responses and contribute to certain autoimmune diseases. Therefore, r…
Ari Benjamin Fitzsimmons · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $48,974 — SIGNIFICANCE: G protein-coupled receptors (GPCRs) are the largest class of membrane proteins in the human genome and are implicated in a wide array of cardiovascular and respiratory diseases. Notably, GPCRs are the targets of one third of FDA approved therapeutics, including drugs prescribed for cor…
TERRY L. SHEPPARD · KEYSTONE SYMPOSIA · 2024 · $6,000 — ABSTRACT Support is requested for a Keystone Symposia conference entitled Fungal Pathogens: Emerging Threats and Future Challenges, organized by Drs. Michail Lionakis, Sarah Gaffen and Mari Shinohara. The conference will be held in Banff, Alberta, Canada from February 18-21, 2024. Human pathogenic f…
Ariel Jade Kuhn · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $73,828 — PROJECT SUMMARY Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of coronavirus disease (COVID-19), has spurred an unprecedented global pandemic. Infection surges necessitate new therapeutic agents that are effective against a rapidly changing virus. Antiviral…
Eric Anthony Sribnick · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $187,635 — PROJECT SUMMARY/ABSTRACT Critical injury, including traumatic brain injury (TBI), remains one of the most common causes of morbidity and mortality in children. Despite efforts to develop pharmacotherapy for TBI, clinical trials have proven ineffective. Improvements in outcome have largely been due t…
BETSY DAVIS · OREGON RES BEHAVIORAL INTERVENTION STRAT · 2024 · $904,287 — Project Summary/Abstract Economically disadvantaged mothers of young children experience disproportionately high rates of depressive symptoms, yet often do not receive treatment due to instrumental and psychological barriers. Remission of maternal depression relates to improvements in both parenting…
JOSEPH M FOX · UNIVERSITY OF DELAWARE · 2024 · $493,511 — Project Summary The goal of this proposal will be to develop a diverse set of new chemical tools centered on tetrazine ligation– the fastest known bioorthogonal reaction. This proposal describes a continued effort to develop new bioorthogonal reagents. Methods will be developed for the safe synthesi…
Matthew J Campen · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $592,021 — SUMMARY Wildland fire disasters raged throughout the western US in recent years, continuing a trend for increasing frequency and severity of such events driven by climate change. Smoke arising from these events covered much of the continent, exposing over 100 million people. Wildland fires in the Ne…
Isaac Cervantes Sandoval · GEORGETOWN UNIVERSITY · 2024 · $328,297 — Summary Learning and memory storage is a complex process that has proven challenging to tackle. Despite significant progress in understanding classical conditioning, it is likely that in nature, the instructive value of reinforcing experiences is acquired rather than innate. In other words, many of …
LIAN LI · EMORY UNIVERSITY · 2024 · $234,750 — Project Summary / Abstract Alzheimer's disease (AD) is a devastating dementia that occurs either in rare, familial forms or in common, sporadic forms. Current understanding of AD pathogenic mechanisms is incomplete, and amyloidocentric clinical trials have failed to show therapeutic efficacy, highli…
Akrit Singh Sodhi · JOHNS HOPKINS UNIVERSITY · 2024 · $470,039 — PROJECT SUMMARY: Diabetes accounts for 10% of healthcare spending in the United States. A growing portion of this cost is spent on treatments for diabetic eye disease, the leading cause of blindness among working-age adults in the developed world. Early nonproliferative diabetic retinopathy (NPDR) …
FREDERICK SHIC · SEATTLE CHILDREN'S HOSPITAL · 2024 · $887,117 — PROJECT SUMMARY/ABSTRACT This heterogeneity of autism spectrum disorder (ASD) results in challenges to developing diagnostic, prognostic, and treatment strategies applicable across the autism spectrum. A search has been underway for decades to identify promising biomarkers, i.e. objectively measured…
Lissah Kyalamboka Johnson · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $44,720 — PROJECT SUMMARY/ABSTRACT Death rates have decreased across many cancer types owing to improved early detection and treatment methods, but remained largely stagnant for ovarian cancer over the last four decades. High grade serous ovarian carcinoma (HGSOC) is the most common and deadly subtype, accoun…
Crystal May Ripplinger · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $719,415 — ABSTRACT Cardiovascular diseases, including ventricular arrhythmias and heart failure, are an important cause of morbidity and mortality in the U.S. Ventricular arrhythmias (VT/VF), after myocardial infarction (MI) and in the setting of cardiomyopathy, remain an important cause of sudden cardiac dea…
Susruta Majumdar · WASHINGTON UNIVERSITY · 2024 · $601,979 — ABSTRACT Opioids until recently were the drugs of choice to treat moderate to severe chronic pain. Decades of intensive research has led to the pharmacological characterization of countless synthetic and semi-synthetic opioid derivatives. However, an ideal compound, devoid of serious side-effects su…
Alexis M. Stranahan · AUGUSTA UNIVERSITY · 2024 · $392,018 — PROJECT SUMMARY The ‘apple-shaped’ anatomical pattern that accompanies visceral adiposity increases dementia risk in humans, but the 'pear-shaped' distribution that reflects subcutaneous adiposity does not predict cognitive impairment and may be protective. Several recent studies, including from our…
Courtney Anne Bouchet · COLORADO STATE UNIVERSITY · 2024 · $77,227 — Project Summary Cardiovascular diseases are the leading cause of death globally and pathologies are exacerbated by chronic stress. Stress-cardiovascular comorbidities are more prevalent in females, however, the neurobiological mechanisms linking stress to cardiovascular outcomes are not well unders…
Tammie Lee Smith Benzinger · WASHINGTON UNIVERSITY · 2024 · $748,349 — Abstract. Oxidative imbalance mediates pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD) and is shown to induce mitochondrial and synaptic dysfunction in neurons. The brains of patients with MCI and AD als…