Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tiffany Joy Braley · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $351,000 — ABSTRACT Approximately 5.7 million Americans have dementia. Alzheimer’s dementia accounts for the majority of cases. The rising prevalence and impact of dementia in the US, coupled with a lack of effective treatments to prevent, cure, or slow dementia progression, have galvanized an urgent need to i…
Yiying Zhang · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $210,348 — Perioperative neurocognitive disorders (PND) – including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorders – are associated with increased morbidity and mortality, high costs of care, and Alzheimer’s Disease and Alzheimer’s Disease Related Dementias …
Nitai Hait · ROSWELL PARK CANCER INSTITUTE CORP · 2024 · $86,750 — ABSTRACT Sphingolipid metabolites and their metabolic enzymes, often dysregulated in cancer, may present a novel but exploitable target for therapeutics against aggressive diseases such as triple -negative breast cancer (TNBC) and epidermal growth factor receptor 2 (HER2+) breast cancers, where new …
Ravi Goyal · UNIVERSITY OF ARIZONA · 2024 · $76,750 — Summary: Preterm infants have a significantly higher incidence of brain damage as a consequence of immature cerebral blood flow (CBF) autoregulation. In contrast to term neonates, preterm neonates are not able to reduce CBF in response to increased systemic BP. In preterm neonates, exposure of fragi…
Dudley William Lamming · AMERICAN AGING ASSOCIATION, INC. · 2024 · $50,000 — Abstract. We are requesting funds to support the 52nd Annual Meeting of the American Aging Association (AGE) that will take place on June 2-5, 2024 in Madison, WI. The 52nd Annual AGE Meeting will be held in conjunction with the Nathan Shock Centers of Excellence in the Basic Biology of Aging Sympos…
ANNA LYSAKOWSKI · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $60,000 — ABSTRACT The Association for Research in Otolaryngology (ARO) is requesting continued support from of an NIDCD Conference Grant for its annual Midwinter Research Meeting (MWM). The MWM is a unique meeting where current basic and clinical research related to otolaryngology is presented. In addition …
JACOB M HAUS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $195,000 — PROJECT ABSTRACT Methylglyoxal (MG) is a potent intracellular glycating agent that forms advanced glycation endproducts. Formed spontaneously from 3-carbon glycolytic intermediates, MG rapidly glycates proteins and nucleotides, damages mitochondria and directly increases reactive oxygen species prod…
Armen I Yerevanian · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $169,240 — This proposal describes a five-year plan for Armen Yerevanian MD to transition to an independently-funded investigator with expertise in the metabolism of aging and the molecular physiology of riboflavin. He will be mentored by Alexander Soukas MD PhD, Associate Professor of Medicine at Harvard Medi…
Caitlin Rancher · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $128,476 — PROJECT SUMMARY Over two-thirds of children experience traumatic events such as child maltreatment, violence, or sudden or violent loss. Many of these children sustain significant emotional and developmental difficulties including trauma symptoms, aggression, and suicidality. Emotional support from …
Gregory Charles Bunt · AMERICAN SOCIETY OF ADDICTION MEDICINE · 2024 · $20,000 — PROJECT SUMMARY/ABSTRACT Project Abstract The International Society for Addiction Medicine (ISAM) is a professional organization, with over 10,000 affiliate members, comprised of members situated in clinical and academic settings in the US and over 40 other countries worldwide. Since 1999, the ISAM …
Shirley Luckhart · UNIVERSITY OF ARIZONA · 2024 · $616,676 — Project Summary Malaria parasites require pantothenate (Pan) from both the insect and mammalian hosts to synthesize coenzyme A (CoA) and acetyl-CoA (AC). Further, mosquito-stage parasites cannot take up preformed CoA from the insect host, so they are entirely dependent on mosquito Pan availability. …
Zhiyu Dai · UNIVERSITY OF ARIZONA · 2024 · $100,223 — Project Summary Pulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling that result in right heart hypertrophy, failure, and premature death. The underlying mechanisms of vascular remodeling and…
Donald Allen Watson · UNIVERSITY OF DELAWARE · 2024 · $317,608 — Nitrogen-rich small molecules are critical to human health as they constitute the vast majority of all known pharmaceutical agents. As the requirements for new drugs become stricter, and as the diseases that are targeted become more complex, the chemical structures of those compounds are also becomi…
DYMPNA GALLAGHER · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $1,209,450 — Obesity is a major contributor to human illness and health care costs by virtue of its functional associations with type 2 diabetes, hypertension, fatty liver, dyslipidemias, various cancers, degenerative brain disease and, very recently, contribution to morbidity and mortality associated with SARS-…
Li Gan · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $1,320,382 — PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is a leading cause of dementia among the elderly and the most prevalent age- related neurodegenerative disease, affecting ~56 million individuals worldwide. Despite of its high heritability (estimates ranging 60-80%) and many genetic variants (resid…
Hanseok Ko · JOHNS HOPKINS UNIVERSITY · 2024 · $204,688 — We will evaluate the biological necessity of an intronic enhancer of SNCA and determine its relevance to Parkinson disease (PD). SNCA is frequently mutated in familial PD; it encodes alpha-synuclein (α-syn), the primary constituent of Lewy bodies (LB). LB formation/accumulation is a pathological hal…
Andrea E Cassidy-Bushrow · MICHIGAN STATE UNIVERSITY · 2024 · $725,518 — Project Summary Although obesity is a serious threat to the nation’s health, little progress has been made in its prevention. Infancy may be an opportune time to prevent its development since the sooner the trajectory towards obesity is halted, the less likely that negative health consequences will …
Jan Grimm · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $627,848 — SUMMARY: The problem: In molecular medicine multiple parameters are combined for a more inclusive evaluation towards personalized medicine. A thorough characterization of a patient’s tumor upfront provides better outcomes, i.e., better insight affords higher survival rates. In contrast and almost an…
ERIK M JORGENSEN · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $323,587 — Communication between nerve cells takes place by the release of neurotransmitters at synapses. Signaling can be extremely rapid – transmitting information via hundreds of action potentials per second. It is not possible to synthesize new synaptic vesicles at this pace, so rapid recycling is essentia…
PHILIP W SHAUL · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $1 — Project Summary This is a renewal application to fund lung-related research training at the University of Texas Southwestern Medical Center, at the postdoctoral (MD, PhD) level. The proposal is born out of a collaborative effort between the Pediatric and Adult divisions involved in lung research at …