NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Brian Antonio Boyd · UNIVERSITY OF KANSAS LAWRENCE · 2024 · $473,017 — PROJECT SUMMARY Families are facing significant challenges during the COVID-19 pandemic, especially those caring for a child with autism spectrum disorder (ASD). A recent SPARK survey1 (N = 8,000) found that approximately 95% of parents reported increases in their child’s challenging behaviors as a …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
DWIGHT J ROUSE · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · 2024 · $385,000 — PROJECT SUMMARY In this application, we detail Brown University/Women & Infants Hospital of Rhode Island (WIH) experience and capabilities that will enable us to be a productive, collaborative, and collegial Center in the NICHD Maternal-Fetal Medicine Units (MFMU) Network. This has been, and will re…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SHIVANI MATHUR GAIHA · BOSTON CHILDREN'S HOSPITAL · 2024 · $248,968 — PROJECT SUMMARY/ ABSTRACT Despite significant efforts to limit youth from accessing and using electronic cigarettes (e-cigarettes), many adolescents and young adults are directly purchasing e-cigarettes from brick-and mortar retail stores. Studies show that pervasive e-cigarette marketing in the ret…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Katherine Marie Eichinger · DUO ONCOLOGY INC · 2024 · $399,970 — PROJECT SUMMARY Annually, pancreatic cancer (PC) has a global incidence of more than 495,000 cases and a mortality rate of almost 460,000 cases. Most of these patients (~80%) receive late-stage diagnoses when their tumors cannot be surgically resected, necessitating pharmacotherapy. A majority of PC…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Barbara Kelley · HEARING LOSS ASSOCIATION OF AMERICA · 2024 · $59,601 — PROJECT SUMMARY The Hearing Loss Association of America (HLAA) is the nation's largest organization representing people with hearing loss. The HLAA Convention, held annually, draws a broad national audience and is key to achieving HLAA's mission "to open the world of communication to people with hea…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jean-Philippe Laurenceau · UNIVERSITY OF DELAWARE · 2024 · $611,003 — Project Summary/Abstract Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer mortality among women in the US (ACS, 2017). High baseline prevalence, increasing screening rates, and better treatments have all contributed to a large population of BC survivors…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Shira Yomtoubian · SALK INSTITUTE FOR BIOLOGICAL STUDIES · 2024 · $76,756 — Project Summary Lung cancer is the leading cause of cancer-related mortality worldwide. Lung tumors driven by mutant KRAS are among the most aggressive and refractory to treatment, due in part by KRAS-driven metabolic reprogramming. Efforts to better understand the pathways regulating metabolic adap…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Moonjung Jung · JOHNS HOPKINS UNIVERSITY · 2024 · $235,510 — Project Summary The overarching goal of this training award is to acquire the skills and experience necessary to become an independent physician scientist with research expertise on fundamental mechanisms of bone marrow failure, with a final goal of developing novel therapies. Maintaining genome int…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PAUL FORSCHER · YALE UNIVERSITY · 2024 · $389,283 — The ADF/cofilin family of proteins play a critical role in actin filament turnover essential to all forms of eukaryotic cell motility. Despite a vast literature on signaling pathways controlling cofilin activity, assessing the function of this important protein in living cells has been hampered by l…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SUBHASH C. PANDEY · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $1,654,361 — Project Summary: Alcohol use disorder (AUD) can be characterized by a pattern of compulsive alcohol drinking or loss of control over alcohol drinking. The positive and negative effects of ethanol appear to be regulated by genetic and epigenetic changes in several key brain regions. Long-term alcohol…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JAMES Y.H LI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2024 · $530,585 — SUMMARY Abnormalities in cerebellar development, especially pathology and dysfunction of Purkinje cells, have been implicated in a wide variety of neurodevelopmental diseases, including ataxia, autism spectrum disorder, schizophrenia, and language impairment. Being one of the earliest-born cerebella…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jeffrey Andrew Sparks · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $732,797 — PROJECT SUMMARY / ABSTRACT Rheumatoid arthritis (RA) is a systemic inflammatory disorder affecting approximately 1.5 million people in the United States. Although parenchymal lung disease, which encompasses interstitial lung disease (ILD) and emphysema, is a common lung complication of RA with incre…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Melinda Chang · CHILDREN'S HOSPITAL OF LOS ANGELES · 2024 · $234,603 — Project summary Cortical visual impairment (CVI) is the leading cause of pediatric visual impairment in developed countries. There is no evidence-based treatment, and design of clinical trials is hampered by the absence of a validated method of visual assessment that captures the numerous aspects of…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
KARL J WAHLIN · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $395,000 — SUMMARY Retinal degenerative (RD) diseases, such as Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), cause dysfunction and cell death of photoreceptor (PR) cells, ultimately leading to blindness. LCA is the leading cause of inherited childhood blindness resulting in a loss of vision a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Guido Silvestri · EMORY UNIVERSITY · 2024 · $909,998 — PROJECT SUMMARY HIV infection of humans and SIV/SHIV infection of rhesus macaques (RMs) persist despite long-term ART. Numerous observations indicate that CD8+ T cells inhibit HIV and SIV replication. More recently, two studies conducted as part of R01-AI-125064 have shown that: (i) CD8+ lymphocytes…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kevin Chui · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $39,884 — Project Summary The incidence of age-related diseases such as Alzheimer’s disease and Parkinson’s disease continues to increase as human lifespan continues to increase. Advancements in science and healthcare have resulted in effective therapies for many diseases but treatments for these debilitating…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kate Tarvestad Laise · UNIVERSITY OF LOUISVILLE · 2024 · $35,822 — Project Summary The proposed research is relevant to public health because corneal blindness is the 4th leading cause of blindness globally and is often preventable with proper healthcare. Blindness arises due to damaged integrity of the corneal epithelium as the result of physical, chemical, or the…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jian-Dong Li · GEORGIA STATE UNIVERSITY · 2024 · $708,660 — Influenza virus is a major pathogen causing seasonal epidemics of disease in the world. Airway epithelium acts as the first line of host antiviral defense. Influenza virus-induced innate immunity plays a critical role in viral clearance. However, if uncontrolled, dysregulated innate immune responses…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rocco George Gogliotti · LOYOLA UNIVERSITY CHICAGO · 2024 · $192,500 — SUMMARY An emerging theme in neurodevelopmental research is that both loss of function and overexpression of the same pathogenic gene can result in autism-associated phenotypes. For many disorders, such precise requirements for protein dosage have complicated what was once thought to be a linear pa…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Mitchell Isaac Parker · DREXEL UNIVERSITY · 2024 · $40,487 — Abstract: RAS proteins (KRAS, NRAS, and HRAS) are the most extensively studied set of mutationally activated oncogenes. Yet we do not completely understand the structural impact of RAS mutations in cancer. As of August 2020, there are 333 experimentally solved wild-type (WT) and mutated RAS structur…