Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jun He · THOMAS JEFFERSON UNIVERSITY · 2024 · $264,296 — Breast cancer (BCa) is the leading cause of women cancer mortality worldwide, and triple negative breast cancer (TNBC) cells accounts for 15-20% BCa. However, higher therapeutic resistance and lower survival of TNBC patients remain the major hinder of BCa treatment. Doxorubicin (Dox) and radiation a…
Paris Adkins-Jackson · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $125,441 — PROJECT SUMMARY / ABSTRACT To reduce racial disparities in Alzheimer’s disease related dementias (ADRD) for US Black and Latinx/a/o older adults, it is crucial to examine key structural determinants of health that occur across the life course, like structural racism. However, limited research explor…
Antonio Luigi Amelio · H. LEE MOFFITT CANCER CTR & RES INST · 2024 · $492,000 — Summary Mucoepidermoid carcinomas (MEC) are the most common type of malignant salivary gland tumor (SGT) with advanced MEC often being fatal due to resistance to conventional therapies. Despite their prevalence in salivary malignancies and occurrence in other tissues throughout the body, a thorough …
ROBERTO DOMINGUEZ · UNIVERSITY OF PENNSYLVANIA · 2024 · $1,569,580 — PROJECT SUMMARY This RM1 proposal focuses on defining and characterizing the integrated systems that support intracellular organelle transport and placement. Rather than just characterizing “molecules” as biophysicists or “organelle dynamics” as cell biologists, our goal is to achieve an atomic-to- …
David Chu · LURIE CHILDREN'S HOSPITAL OF CHICAGO · 2024 · $190,080 — PROJECT SUMMARY This Career Development Award will help David I. Chu, MD, MSCE, become an independent surgeon-scientist who will develop the evidence to improve kidney, bladder, and overall health in young patients with spina bifida. Dr. Chu will use this award to build on his existing foundation in…
BIN LIU · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $632,874 — Abstract: The goal of this proposal is to develop an engineered T cell therapy with potential of translation into human testing. We will develop a clinically optimized combination antigen sensing prime-and-kill circuit T cell for precise recognition and enhanced elimination of mesothelioma, a rare d…
Daniel Walker Belsky · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $164,500 — The purpose of this grant is to obtain preliminary data to support a larger study that would recontact 11,240 participants of a successful multicenter randomized controlled trial of small class sizes called Project Student/Teacher Achievement Ratio (STAR). This future study would provide critically …
Timothy C Cope · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $462,934 — Abstract The toxic effects of platinum-based compounds (PBCs) commonly used in chemotherapy weigh against their usefulness as the major option for successfully combating lethal cancers. The decision to opt for survival leaves people worldwide to suffer with PBC neurotoxicity that reduces quality of …
Vijayalakshmi Santhakumar · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2024 · $443,495 — Project Summary: Neurological disorders such as epilepsy and memory loss develop several years after traumatic brain injury (TBI) and are a major source of physical disability and economic burden. The delay between the initial trauma and eventual disability results from progressive neuropathology th…
DENISE AIMEE HIEN · CITY COLLEGE OF NEW YORK · 2024 · $315,742 — Program Director/Principal Investigator (Last, First, Middle): Ruglass, Lesia, M. PROJECT SUMMARY/ABSTRACT This renewal proposal responds to PAR 19-258 and describes an addiction research training program designed to increase the number of interdisciplinary scientists interested in and capable of s…
Geoffroy O Laumet · MICHIGAN STATE UNIVERSITY · 2024 · $388,249 — Persistent pain is common and debilitating. Long after apparent remission of the pain initiated by the primary insult, some patients experience relapse and recurrent episodes of severe pain. The long-term goal of this project is to decipher mechanisms that regulate the balance between remission and …
Gabriel G Haddad · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $166,591 — ABSTRACT Early stage pediatric faculty members, even those who have potential for success as academic investigators based upon substantial experience in basic research, will require further intensive training and mentoring in basic research to successfully embark upon an independent research career.…
Lei Wang · UNIVERSITY OF SOUTH FLORIDA · 2024 · $315,744 — Kidney transplantation is a life-saving procedure for patients with end-stage kidney disease. Although the short-term organ survival post-transplantation has improved dramatically over the past decades, the long-term outcomes remain unsatisfied with the survival half-lives for transplanted renal gra…
Seungmoon Song · NORTHEASTERN UNIVERSITY · 2024 · $235,676 — Project Summary / Abstract The candidate's long-term objective is to enable optimal and customized intervention to improve mobility. Mo- bility is an essential physical activity for maintaining an active lifestyle and functional independence and is a common issue for older adults, where musculoskele…
John C Alverdy · COVIRA SURGICAL · 2024 · $400,000 — PROJECT SUMMARY Covira Surgical, Inc. is developing a first-in-class agent for preventing chemotherapy-related gastrointestinal (GI) toxicities and lethal infections. Chemotherapy renders patients more susceptible to infection - many if most of which originate from the gastrointestinal track flora. …
John ChisolmGray Imrie · DUKE UNIVERSITY · 2024 · $474,719 — Transgender-specific Differentiated HIV Care Models: An Implementation Science Study Project Summary/Abstract Despite a disproportionate burden of HIV, transgender people are less likely to achieve viral suppression than the general population and have low engagement in PrEP services. Intervenable …
Richard Piet · KENT STATE UNIVERSITY · 2024 · $338,580 — The circadian clock is a fundamental regulator of many aspects of physiology and behavior, including reproduction. Reproductive success depends on appropriate daily timing of neuroendocrine events that control ovulation. Kisspeptin (Kiss1) neurons in the preoptic area (POA) of the hypothalamus play …
Andrew Lin · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $196,525 — Project Summary/Abstract A small subset of pituitary adenomas demonstrates aggressive behavior as defined by rapid growth following treatment, namely hormonal therapy, surgery, and radiation. Aggressive pituitary tumors are devastating, life- limiting malignancies with two patterns of growth: (1) th…
Jonathan S Reichner · RHODE ISLAND HOSPITAL · 2024 · $82,000 — Abstract Neutrophils are not often considered as cancer killing immune cells in the same way that natural killer cells, cytotoxic T cells and macrophages. However, the inherent capability of neutrophils to be cytotoxic is clinically evident in diseases of hyperinflammation (such as sepsis) where act…
Gregory Dyer Lewis · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $1,396,877 — PROJECT SUMMARY/ABSTRACT Heart failure (HF) with preserved ejection fraction (HFpEF) represents ≈50% of HF, with limited methods for prevention and treatment. Current approaches to detect/treat HFpEF rely on cardiac phenotypes obtained at rest, missing reserve capacity impairments in multiple organ …