Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Judith A Steen · BOSTON CHILDREN'S HOSPITAL · 2024 · $778,347 — Project Summary/Abstract In Alzheimer's disease (AD), the accumulation of intracellular posttranslationally modified Tau aggregates, is a hallmark of AD pathology and a strong correlate of cognitive impairment. While the dozen or so Posttranslational Modifications (PTMs) on Tau in pathological aggre…
Benjamin D Auerbach · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $138,690 — PROJECT SUMMARY Sensory hypersensitivity, particularly in the auditory realm, is one of the most common and debilitating features of autism spectrum disorders (ASD). Not only is auditory hypersensitivity a core deficit and important clinical problem in ASD, but it likely contributes to and reflects…
Laura Fejerman · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $423,619 — PROJECT SUMMARY Breast cancer is the most common cancer in women and the second leading cause of cancer death in the United States (US). Although women included in the US Census racial/ethnic categories Hispanic/Latina (H/L) and Asian American/Pacific Islander (AA/PI) have relatively low breast canc…
Daria Esterhazy · UNIVERSITY OF CHICAGO · 2024 · $340,096 — PROJECT SUMMARY/ABSTRACT Hypothesis: Diseases of the pancreas are life-threatening, including pancreatic cancer (PDAC), affecting exocrine cells, and autoimmune diabetes (T1D), destroying insulin-producing β cells. External factors like infections and diet are implicated as triggers, but the disease…
Lily Charpentier · DARTMOUTH COLLEGE · 2024 · $48,974 — ABSTRACT Cystic fibrosis (CF) is characterized by the formation of thick mucus in the lung leading to chronic infection of various pathogens that are prone to developing antibiotic tolerance. Despite effective modulator therapy (HEMT) that improves lung function and many clinical outcomes, HEMT does…
Nancy Lan Guo · SOSTOS LLC · 2024 · $400,000 — Project Summary Sostos, LLC has developed a qRT-PCR-based microfluidic 7-gene assay (CATOS-LU) that predicts recurrence or progression to metastasis of non-small cell lung cancer (NSCLC) in a patient who has undergone resection for stage 1 cancer without high-risk features at the time of surgical in…
Arkadij Elizarov · TRACE-ABILITY, INC. · 2024 · $1,000,000 — ImmunoPET Imaging allows visualization of biological processes in the body via radiolabeled monoclonal antibodies (mAb’s) with Positron Emission Tomography (PET). ImmunoPET has proven to be a groundbreaking innovation yielding actionable medical information that is not otherwise obtainable in many d…
Guanghui Zong · GLYCOT THERAPEUTICS, LLC · 2024 · $758,302 — Project abstract/summary In the proposed research, GlycoT will expand its cutting-edge chemoenzymatic platform by further optimizing and streamlining a one-pot single-zyme glycan-specific conjugation technology, that can be applied to a wide variety of application. Conjugation of various functional …
DARRICK Albert CARTER · PAI LIFE SCIENCES, INC. · 2024 · $995,460 — PROJECT SUMMARY Lymphatic filariasis (LF) is one of only a small number of diseases classified as potentially eradicable. In 1997, the World Health Assembly passed a resolution to eliminate LF as a public health problem and the approach involved yearly concurrent mass drug administration (MDA) to th…
Christian J Goossen · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $48,974 — Project Summary Pulmonary arterial hypertension (PAH) is a rare, devastating disease with the initial pathognomonic instigator being a combination of genetic and environmental (injurious) factors including hypoxemia and reactive oxygen species (ROS) signaling. PAH is characterized by aggressive lung…
Peter Burks · ACTIVE LIFE SCIENTIFIC, INC. · 2024 · $1,716,342 — Abstract Most patients who fracture have non-osteoporotic bone mineral density. Often, the result of a fracture is devastating and results in substantial morbidity and health care costs. One cause of fragility in these patients is poor bone quality that subsequently contributes to higher risk for fr…
Nicole Colussi · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $48,974 — PROJECT SUMMARY Myocardial ischemia-reperfusion injury is a multifactorial event characterized by oxidative stress and mitochondrial damage. Interrupted blood supply establishes ischemia, and restoration of flow introduces a second wave of damage caused by uncontrolled reduction of oxygen (i.e., sup…
Corey Acker · POTENTIOMETRIC PROBES, LLC · 2024 · $282,266 — PROJECT SUMMARY/ABSTRACT POTENTIOMETRIC PROBES The overall goal of this Phase I SBIR project is to expand the capabilities of tools, invented by the founders of Potentiometric Probe, LLC, for high-fidelity optical recording of electrical activity in cardiac cells, tissues, and whole hearts. Potentio…
Gregory F Sonnenberg · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $508,500 — PROJECT ABSTRACT The gastrointestinal tract is colonized with trillions of normally beneficial microbes, termed the microbiota, that are essential for human health. However, the pathogenesis of numerous infectious, inflammatory, and metabolic diseases involves a loss of immunologic tolerance to the …
Daniel Burkhalter · RTUTOR, LLC · 2024 · $273,987 — PROJECT SUMMARY Large data sets are routinely collected in biomedical research. Analyzing such datasets often requires coding, which can be challenging and time-consuming for researchers without computational expertise. Capitalizing on recent breakthroughs in artificial intelligence (AI), we develo…
Rachita Sumbria · CHAPMAN UNIVERSITY · 2024 · $342,000 — Project Summary/Abstract Our application aims to develop a blood-brain barrier (BBB) penetrating erythropoietin (EPO) as a therapeutic for Alzheimer’s disease (AD) and continues to pursue our long-term goal to develop BBB-penetrable biologics for central nervous system (CNS) diseases, especially fo…
Kathryn A. Cunningham · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $275,042 — PROJECT SUMMARY/ABSTRACT Drug overdose deaths and substance use disorders (SUDs) constitute a major, high-impact health problem in the U.S. This renewal of the training grant Translational Explorations in Substance Use Disorders (T32 DA007287) at the University of Texas Medical Branch (UTMB) propose…
Marianne S Matthias · RLR VA MEDICAL CENTER · 2024 — Background: The COVID-19 pandemic severely disrupted healthcare. These changes are likely to have especially profound implications for Veterans obtaining regular care for chronic conditions, such as chronic pain—particularly when Veterans are obtaining nonpharmacologic treatments, which often requir…
Marian L. Fitzgibbon · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $375,332 — This renewal application for Years 31-35 of the University of Illinois at Chicago’s Cancer Health Equity Career Development Program (CHECDP) is designed to support a diverse, equitable, and inclusive scientific environment to prepare the next generation of cancer researchers through health equity ed…
Kristina Marie Brooks · UNIVERSITY OF COLORADO DENVER · 2024 · $114,818 — Project Summary & Abstract Pregnant and postpartum women living with HIV (WLWH) and latent tuberculosis (TB) infection (LTBI) are at high risk of progressing to active TB. Safe and effective treatment during the latent phase is critical to preventing active TB, in addition to reducing TB-related mat…