Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MARK MERCOLA · STANFORD UNIVERSITY · 2024 · $597,054 — PROJECT SUMMARY Cardiovascular complications of cancer therapy significantly contribute to the global burden of cardiovascular diseases. Although remarkable progress has been made in understanding the genetic basis of doxorubicin- induced cardiotoxicity (DIC), we cannot predict which patients will b…
Lin Zhu · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $120,177 — Does Senescence Impair the Cardiovascular Benefits of Menopause Hormone Therapy? Atherosclerotic cardiovascular disease (ASCVD) causes approximately one-third of all deaths worldwide. The protection in women against ASCVD is reduced with aging and menopause. Menopausal hormone therapy (MHT) has not…
PRABIR ROY-CHAUDHURY · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $523,728 — ABSTRACT Arteriovenous fistulae (AVF) are the preferred mode of permanent dialysis vascular access because of better long-term survival and reduced infection risks as compared to dialysis grafts and catheters. Unfortunately, AVFs have a maturation failure rate (defined as inadequate diameter and blo…
Gregory H Underhill · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $446,688 — Project Summary The bipotential differentiation of liver progenitor cells to hepatocytes and biliary epithelial cells (cholangiocytes) is integral to liver development, regeneration, and diseases including bile duct paucity and liver cancer. In particular, the most common congenital liver diseases a…
Roy Travis Sabo · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $172,216 — In many studies on the risk of disease, investigators analyze the spatial patterns of health outcomes and evaluate residential environmental exposures at the time of study enrollment in hopes of identifying potential causal environmental factors. However, for cancers with long latencies like bladder…
Jacob Jeffrey Zulk · BAYLOR COLLEGE OF MEDICINE · 2024 · $48,974 — Urinary tract infections (UTIs) are responsible for a large public health burden with over half of women experiencing a UTI during their lifetime. These infections, primarily in women, older adults, and those with underlying conditions such as diabetes, are responsible for over $3.5 billion in healt…
Emily Kolenbrander Ho · PRINCETON UNIVERSITY · 2024 · $76,756 — PROJECT SUMMARY/ABSTRACT Signaling pathways pattern cell fate choices in the developing embryo, but how do only a limited number of pathways control the complex events of development? Spatial signaling gradients as well as temporal signaling dynamics are known to be important for directing multiple…
Yuan He · NORTHWESTERN UNIVERSITY · 2024 · $71,061 — Summary Transcription is the first step to read out the genetic information stored in the chromosome. In eukaryotes, three multi-subunit RNA polymerases (Pols), Pol I, II, and III transcribe the 25S ribosomal RNA (rRNA), protein-coding, and short non-coding RNAs such as transfer RNA (tRNA) and 25S r…
Bin Wang · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $352,047 — ABSTRACT DNA double-strand breaks (DSBs) are one of the most deleterious lesions. The cellular responses to DSBs involve a sophisticated DNA damage response network that detects, signals and repairs the lesion; failure of this system results in mutation, deletion and other alteration of genome and u…
AARON APONICK · UNIVERSITY OF FLORIDA · 2024 · $292,089 — Project Summary/Abstract This objective of this proposal is to develop new synthetic methods for the enantioselective synthesis of bioactive molecules. Studies are centered on utilizing a new class of atropisomeric chiral biaryl ligand being developed in our laboratory. Preliminary work has found th…
Sung Jin Park · EMORY UNIVERSITY · 2024 · $584,744 — Project Summary/Abstract The recent increasing prevalence, severity, and healthcare burden of sinoatrial (SA) node dysfunction emphasize the need for more detailed studies of SA node functions that allow for effective therapy to treat and prevent SA node dysfunction. The major mechanisms of the dys…
Michelle Birkett · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $659,491 — PROJECT SUMMARY Over the last two decades, a growing literature has demonstrated that social factors drive both drug use and infectious diseases such as HIV. Simultaneously, epidemic modeling has become vital for reducing the spread of HIV, as it allows insight into mechanisms of spread, forecasts f…
Bihui Hilda Ye · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $514,837 — PROJECT SUMMARY/ABSTRACT Adult T-cell leukemia/lymphoma (ATLL) is a disease of malignant CD4+ T cells that develops in human T- lymphotropic virus-1 (HTLV-1) carriers. The 3-yr overall survival is an abysmal 25% even when managed with the most aggressive chemotherapy. No outcome-changing targeted tr…
Evan Fletcher · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $1,377,033 — PROJECT ABSTRACT Alzheimer's disease and related dementias (ADRD) are known causes of cognitive and functional decline, but some individuals are more resilient to these diseases and continue to function normally despite associated brain changes. Cognitive reserve has been invoked to explain better c…
Alessandro Grattoni · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $816,407 — PROJECT SUMMARY/ABSTRACT Maternal mortality and AIDS are among the leading causes of death in reproductive-age women globally due to unintended pregnancy and the disproportionate burden of HIV infection. While effective prevention methods exist, only 21% of women have access to modern contraceptives…
Joseph Genereux · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2024 · $310,125 — PROJECT SUMMARY The secretory pathway must fold and traffic one third of the proteome, while handling an exceptional dynamic range of client load. Quality control mechanisms prevent proteostasis in the secretory pathway from being overwhelmed by proteins in non-native states. One such mechanism is p…
Deanna Barch · WASHINGTON UNIVERSITY · 2024 · $760,823 — Motivational impairments are a key feature of both psychotic and mood disorders. Decreases in motivation impair work and social function transdiagnostically, reduce quality of life, and increase public health demands. Current treatments are not sufficiently effective at reducing impairments in motiv…
Matthew J Paszek · CORNELL UNIVERSITY · 2024 · $428,910 — Project Summary/Abstract Cancer cells construct a cellular glycocalyx with biochemical and biophysical attributes that protect against attack by effector immune cells. Currently, our mechanistic understanding of how the cancer-cell glycocalyx may physically interfere with any of the multiple pathway…
Bernd G. Schnabl · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $499,159 — Project Summary Alcohol associated health problems are a major medical burden in industrialized countries. Patients with alcohol-associated liver disease show intestinal bacterial dysbiosis and increased intestinal permeability. Although there is considerable progress in understanding the interactio…
PARTHA ROY · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $381,058 — Breast cancer the most frequently diagnosed non-skin cancer in women, ranks second among cancer deaths in women in the United States. The vast majority of these deaths are due to metastasis. Dysregulated expression and/or activity of actin-regulatory proteins contribute to the motile phenotype that …