Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Daolin Tang · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $353,971 — Abstract Ferroptosis is a recently recognized form of regulated cell death driven by lipid peroxidation. It is an emerging field in cancer biology, and the detailed molecular regulators of ferroptosis are largely unknown. We recently demonstrated that upregulation of metallothionein (MT)-1G express…
Stefano Tarantini · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $181,250 — PROJECT SUMMARY/ABSTRACT Cognitive impairment associated with Alzheimer’s disease and Related Dementias (ADRD) and aging has emerged as one of the major public health challenges of our time. Recent clinical studies, as well as those in animal models, support that preservation of cognitive health de…
Melissa Ramirez · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $120,767 — Project Summary/Abstract This proposal focuses on the synergy of experiments and computations in (1) understanding fundamental reactivity in organic and organometallic transformations and (2) enabling reaction design for the discovery of methods for enantioselective spirocycle synthesis and radical…
Alexander Russell Lucas · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $123,519 — 1 PROJECT SUMMARY 2 A primary goal of this K01 proposal is to equip the candidate, Dr. Alexander Lucas, with the expertise to become 3 an independent investigator who is able to utilize state-of-the-art imaging techniques to evaluate subclinical 4 outcomes that predict future cardiovascular (CV) …
PERRY E BICKEL · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $519,551 — Project Abstract/Summary The rising prevalence of obesity and type 2 diabetes threatens to limit human healthspan by increasing the risks for cancer and cardiometabolic disease and to impose overwhelming economic burdens. New therapeutic strategies are urgently needed. Since the discovery of functio…
Takuto Greco Chiba · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $119,857 — PROJECT SUMMARY/ ABSTRACT A dire consequence of acute kidney injury (AKI) is a dramatically increased risk to develop chronic kidney disease (CKD). CKD accounts for 6.7% of Medicare expenses. Understanding the mechanisms by which AKI progresses to CKD is essential for developing therapies, for which…
GIDON S FELSEN · UNIVERSITY OF COLORADO DENVER · 2024 · $332,868 — PROJECT SUMMARY (ABSTRACT) Our long-term goal is to elucidate the systems and circuits, within and across brain regions, responsible for decision making. The objective of this proposal is to examine the neural circuit basis for how, in the face of sensory uncertainty, perceptual decisions are adapti…
Amy Dunn · JACKSON LABORATORY · 2024 · $849,854 — PROJECT SUMMARY Alzheimer’s disease is the most common cause of dementia in the elderly, but there are a number of other related dementias that exhibit substantial overlap in the behavioral, cognitive, and neuropathological manifestations of the disease. In fact, the majority of dementia cases likel…
Bo Li · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $386,817 — Project Summary/Abstract Cancer immunotherapy has achieved remarkable clinical success treating late-stage tumors, yet the response rates remain low and the side effects are often severe. Designing effective immunotherapies relies on accurate identification of tumor-reactive T cells. This is an extr…
Rene Opavsky · UNIVERSITY OF FLORIDA · 2024 · $58,098 — PROJECT SUMMARY Project title: Dnmt3b activities in mouse development DNA methylation is an epigenetic modification involved in the transcriptional regulation of genes involved in development and differentiation, and its deregulation contributes to human pathogenesis. It is catalyzed by the family o…
Yong Lu · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $369,383 — Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large established tumors. Unexpectedly, we found that these T cells promoted killing of antigen-loss-variants (ALVs) in vivo and preve…
FARROKH DEHDASHTI · WASHINGTON UNIVERSITY · 2024 · $595,711 — ABSTRACT Approximately 70% of breast cancers (BCs) are estrogen receptor (ER) positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-). Endocrine therapy (ET) reduces recurrence risk and improves survival for many in this group. However, despite standard of care and adjuvant ET, …
Dina Katabi · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $103,072 — PROJECT SUMMARY Chronic itch affects 13% of the population and is associated with over $90 billion in annual population- expenditures in the US. It has a profound negative impact on quality of life, and is often as debilitating as chronic pain. Yet, there are currently no FDA-approved treatments for…
Hala Galal El-Nahal · DUKE UNIVERSITY · 2024 · $41,436 — PROJECT SUMMARY The claustrum is a narrow, subcortical sheet of gray matter with interconnections across the cerebral cortex. Its irregular shape and deep location make it difficult to study with classical neurophysiological techniques. Recent genetic technologies such as optogenetics provide new ho…
Corey S Cutler · DANA-FARBER CANCER INST · 2024 · $2,508,066 — Summary Chronic GVHD (cGVHD) is the major cause of late morbidity, mortality and compromised organ function after allogeneic hematopoietic stem cell transplant (HCT). It can affect essentially all organs and tissues, including the lungs, where the disease is termed Bronchiolitis Obliterans Syndrome …
Bogdan Bintu · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $395,000 — Project Summary/Abstract Understanding the mechanisms of gene and chromatin regulation and their roles within a multicellular organism has relevance across many disciples such as synthetic biology, medicine, developmental biology and neuroscience 1–3. Large-scale efforts of the genomics community h…
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2024 · $303,393 — PROJECT SUMMARY This renewal application builds on our discovery that the shape of nanoparticle-based constructs—what we define as structural valency—plays a key role in preserving the targeting ligand characteristics of nanoconstructs even when coated by a protein corona. Protein corona formation …
Javier Gordon Ogembo · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2024 · $840,321 — PROJECT SUMMARY More than 44,000 new cases of Kaposi sarcoma (KS) are reported globally each year, 84% of which occur in Africa. This and other Kaposi sarcoma-associated herpesvirus (KSHV)-induced malignancies predominate in people with acquired or iatrogenic immunodeficiencies. Although KSHV can be…
Leonard B Bacharier · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $1,663,001 — ABSTRACT The overarching goals of this proposal are 1) to maintain retention of children in the INSPIRE birth cohort with emphasis on diversity, and implementation of the ECHO Cohort Protocol with high fidelity, and 2) tackle the major limitation in diagnosis and management of childhood asthma - ad…
Brandon Chen · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $42,094 — PROJECT SUMMARY Colorectal cancers (CRC) are characterized as having a hierarchical organization requiring proliferating and de-differentiated stem cells to maintain tumor growth and progression. Cellular plasticity underlying colorectal cancer is essential for a process which occurs following selec…