Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Katherine Paige Lemon · BAYLOR COLLEGE OF MEDICINE · 2024 · $400,000 — The objective unifying our two areas of NIGMS-funded research is to identify molecular mechanisms underlying microbe-microbe and microbe-host interactions involving D. pigrum and nasal Corynebacterium species that shape the human nasal microbiota. Evidence indicates that Corynebacterium species and …
Douglas S. Hawkins · PUBLIC HEALTH INSTITUTE · 2024 · $23,864,727 — PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically. The overall 5-year survival rate for childhood cancers, many of which were uniformly fatal in the pre-chemotherapy era, …
Farhan Qureshi · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $28,079 — Project Summary Type 1 diabetes (T1D) is a devastating autoimmune disease affecting over 1.25 million Americans that currently has no cure. Therapies which target autoimmunity in T1D have shifted away from broadly immunosuppressive agents such as cyclosporine, and now focus on enhancing immune toler…
Patrick D Ganzer · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $477,556 — Abstract Almost all sympathetic outflow control pathways travel through the spinal cord for affecting the peripheral tissues. Cervical spinal cord injury impacts sympathetic outflow control, leading to several debilitating deficits (in addition to paralysis), including an inability to redistribute b…
Tomokazu Souma · DUKE UNIVERSITY · 2024 · $484,168 — PROJECT SUMMARY Acute kidney injury (AKI) is a major health problem, afflicting 1.2 million hospitalized patients annually in the US. Maladaptive renal repair after AKI promotes development of chronic kidney disease (CKD), leaving affected patients at high risk for dialysis dependency, cardiovascula…
Thomas G Fazzio · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $510,739 — PROJECT SUMMARY Although the “master regulators” that maintain the self-renewal of pluripotent embryonic stem cells and extraembryonic trophoblast stem cells are relatively well understood, little is known about how these transcription factors are regulated in vivo at early stages of embryogenesis. …
Samit Ghosh · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $608,926 — PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD), widespread among individuals with sickle cell disease (SCD), is a significant contributor to morbidity and early mortality. The progressive deterioration of renal health in SCD is associated with chronic intravascular hemolysis. However, the mec…
Umesh S Deshmukh · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 2024 · $500,954 — Sjögren’s Syndrome (SS) is a chronic and debilitating systemic autoimmune disorder afflicting multiple organ systems. The targeting of the exocrine salivary and lacrimal glands by an autoimmune and inflammatory response leads to organ dysfunction causing reduced fluid secretion, which manifests into…
Robert L Lalonde · UNIVERSITY OF COLORADO DENVER · 2024 · $99,661 — Human diseases are seldom confined to individual tissues or organs, but instead present with a spectrum of comorbidities. A common example includes a group of congenital diseases with linked heart, limb, and lung defects. Using zebrafish as model, the goal of my research is to uncover how individual…
MEGAN MORIARTY KELSEY · UNIVERSITY OF COLORADO DENVER · 2024 · $632,519 — PROJECT SUMMARY Obesity and subsequently type 2 diabetes (T2D) is increasingly common in adolescents, but the phenotype of youth-onset T2D (YO-T2D) differs from adults. The NIDDK TODAY study we helped lead, demonstrated that youth with T2D had a high (≈50%) and rapid failure rate on oral medications…
Jan E Carette · STANFORD UNIVERSITY · 2024 · $532,301 — PROJECT SUMMARY Pathogens have evolved to co-opt cellular functions to support their replication and spread while inactivating innate immune mechanisms that restrict their growth. Discovery and characterization of cellular components that regulate pathogenesis hold promise for revealing new approach…
Julia A Kovacs · UNIVERSITY OF WASHINGTON · 2024 · $427,686 — Project Summary Cysteinate-ligated non-heme iron superoxo intermediates (RS-FeIII-O2•–) play a key role in the mechanisms of isopenicillin N-synthase (IPNS) and cysteine dioxygenase (CDO). The former provides our only source of β- lactam antibiotics, and the latter is known to prevent metastases of …
ASHWIN BALAGOPAL · TRIAD NATIONAL SECURITY, LLC · 2024 · $904,941 — Summary Significance: Hepatitis B virus (HBV) infects ~260 million people worldwide and is the leading cause of liver disease and hepatocellular carcinoma (HCC) in the world. Despite an effective vaccine for infection prevention, chronic hepatitis B virus infection (CHB) is difficult to cure once es…
ALISON TOVAR · BROWN UNIVERSITY · 2024 · $586,797 — The diets of US children are suboptimal and effective primary prevention interventions are urgently needed to shape dietary behaviors early in life, especially among Latinx families, who experience higher prevalence of obesity and cardiovascular disease. The community energy balance framework sugges…
TIMOTHY A SPRINGER · BOSTON CHILDREN'S HOSPITAL · 2024 · $692,334 — Abstract. Transforming growth factor β2 (TGF-β2) is critically important for heart and vascular development and repair. TGF-β2 dysregulation is seen in patient TGF-β2 mutations, systemic sclerosis, and Kawasaki disease, which have cardiovascular sequelae such as aortic aneurysms and cardiac fibrosis…
Saori Furuta · CASE WESTERN RESERVE UNIVERSITY · 2024 · $349,874 — In cancer cells and the tumor microenvironment, arginine metabolism is often shunted into the pathways that produce polyamines, small polycationic metabolites essential for cell growth and immuno-suppression. Such mechanisms in part account for the refractoriness of certain types of cancers, includi…
Anelia Horvath · GEORGE WASHINGTON UNIVERSITY · 2024 · $178,690 — Recently, Single Nucleotide Variants (SNV) detection from single cell RNA sequencing (scRNA-seq) experiments have started to emerge. These studies have demonstrated the utility of scRNA-seq SNV assessments to characterize intra-tumoral heterogeneity, define mutation-associated expression signatures,…
Kaitlin Sheerin · RHODE ISLAND HOSPITAL · 2024 · $195,284 — PROJECT SUMMARY/ABSTRACT Although cannabis use has declined among youth in recent years, the rates of cannabis use among youth in the juvenile justice system have steadily increased, including among youth with early juvenile justice involvement. This rise is concerning because cannabis use among ear…
Hernando Martin Lopez-Bertoni · HUGO W. MOSER RES INST KENNEDY KRIEGER · 2024 · $393,854 — Despite aggressive therapy consisting of surgery followed by radio/chemotherapy GBM recurs in almost all patients with a progression-free survival of only 10 weeks. Currently there are no proven therapies to treat recurrent GBM largely due to our inadequate molecular understanding of the disease. Gl…
Jimmy Kuang-Hsien Hu · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $353,364 — Project Summary Effective utilization of somatic stem cells to repair injured tissues or to bioengineer organs is an important goal in regenerative medicine. However, clinically-proven application of stem cells in therapies remains limited in medicine today. The translational hurdles are in large pa…