Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Matteo Ligorio · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $445,861 — Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDAC patients respond. Therefore, identifying novel therapies is an urgent and unmet need in the PDAC field. One of the eme…
Kristina Roberts · STEMCULTURES, LLC · 2024 · $826,379 — Scientific Abstract: The frequent use of fetal bovine serum (FBS) to support cell cultures is challenged by lot-to-lot variability, supply constraints, pathogen contaminants and ethical questions. These issues have increased significance due to the burgeoning use of FBS in cell research and therapy …
Peter Nikolaevich Kalugin · HARVARD MEDICAL SCHOOL · 2024 · $53,974 — Project Summary The central goal of this proposal is to elucidate how leptin transport into the cerebrospinal fluid (CSF) and brain is gated at the choroid plexus (ChP), how such gating influences the action of leptin on reward- related dopaminergic neurons, and how saturated ChP transport may contr…
Alfredo Luis Sklar · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $188,136 — Abstract Psychosis is a debilitating chronic illness associated with marked impairments of functional capacity in individuals and a significant economic burden for society. Despite various treatment options to address the positive symptoms of the illness, relatively few have been successfully develo…
Xing Dai · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $431,750 — PROJECT SUMMARY Tissue stem cells are rare, undifferentiated cells that are capable of self-renewal and are essential for fueling the homeostasis and regeneration of the tissue in which they reside. They are often quiescent, and when activated, they proliferate and differentiate to produce mature c…
Leyla Isik · JOHNS HOPKINS UNIVERSITY · 2024 · $624,461 — Project Summary The ability to perceive and understand social interactions is crucial to daily life, and characteristically altered in autism. From a brief glance, we can effortlessly recognize whether people are interacting, whether the interaction is cooperative or competitive, and its communicati…
Russell Norris · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $559,990 — PROJECT SUMMARY Based on genetic and cellular discoveries made in the PI lab and his collaborators, this proposal focuses on novel mechanisms that are critical for formation of heart valves. Data presented in the proposal are an evolution of our studies presented in the first round of funding and sh…
Jessica Tooley · WASHINGTON UNIVERSITY · 2024 · $34,908 — PROJECT SUMMARY Opioid use disorder is an urgent public health crisis in the U.S. and roughly 30% of Americans prescribed opioids misuse their medications. The overwhelming reason people with opioid use disorder continue taking opioids is to avoid withdrawal. Opioid withdrawal is physically painful …
Matthew Blake Greenblatt · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $361,713 — Project Summary/Abstract Recent work establishes that skeletal blood vessels are not just mere channels for blood, but instead play an active role in supporting bone formation. However, it is unknown which types of blood vessels provide this support, how these blood vessels alter the production of b…
Baodong Sun · DUKE UNIVERSITY · 2024 · $646,060 — ABSTRACT Glycogen storage disease type III (GSD III) is an autosomal recessive inherited disorder caused by deficiency of glycogen debranching enzyme (GDE) that leads to excessive accumulation of abnormal glycogen (limit dextrin) in muscle and liver tissues. The majority of patients (~85%) have both…
Yue Qin · BROAD INSTITUTE, INC. · 2024 · $95,948 — Project Summary/Abstract Understanding of genetic interactions can lead to therapeutic design for individual cancer patients by targeting the specific genetic vulnerability in the cancer genome. For example, by identifying gene pairs that pose severe fitness defects when knocked out simultaneously (…
Gregory Westcott · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $164,484 — Project Summary/Abstract Adipose tissue homeostasis and expansion requires the coordination of multiple cell types to accommodate increases in tissue volume and metabolic requirements. An important component of adipose tissue regulation is the lymphatic vascular system, which is responsible for the …
RENATO J AGUILERA · UNIVERSITY OF TEXAS EL PASO · 2024 · $786,920 — Project Summary The primary mission of the proposed U-RISE at UTEP is to develop a cohort of diverse, research-oriented underrepresented (UR) undergraduate students who possess the requisite knowledge, skills, and enthusiasm to be competitive for and advance into biomedical sciences doctoral degree …
JOHN D STOREY · PRINCETON UNIVERSITY · 2024 · $365,761 — Project Summary Title: Models and Methods for Population Genomics Abstract: Understanding genome-wide genetic variation and its role in health-related complex traits in humans is one of the most important goals of modern biomedical research. There continues to be a substantial need for new statistic…
Sylvia Fitting · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $194,375 — Project Summary In the context of human immunodeficiency virus (HIV) infection, cannabis use is an important topic and is the most commonly used drug among people living with HIV (PWH), despite the success of combined antiretroviral therapy (cART). Cannabis use is known to alleviate common symptoms …
Daniel Charles Castro · WASHINGTON UNIVERSITY · 2024 · $523,855 — Project Summary The primary goal of this R01 is to determine the computational and functional role of endogenous opioids in specific dorsal midbrain nuclei on motivated behaviors. The preponderance of mental illness in the United States results in tens of millions of dollars in healthcare costs. Whi…
Meghan Halley · STANFORD UNIVERSITY · 2024 · $178,616 — The breakthroughs in diagnosis of rare diseases made possible by genome sequencing (GS) are some of the most exciting in medicine today. Rare diseases affect nearly 30 million individuals in the United States, and two-thirds of those affected are children. Studies suggest that GS (including exome an…
Hadi Hosseini · STANFORD UNIVERSITY · 2024 · $745,073 — PROJECT SUMMARY Accumulating neuropathological and animal studies suggest that AD pathology impacts brain microstructure years before clinical manifestation of the disease. Various processes involved including alterations in dendritic arborization and spines, neurite morphology, synaptic density, an…
Kathrin Banach · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $660,039 — PROJECT SUMMARY/ABSTRACT Atrial excitation-contraction coupling (ECC) and sarcoplasmic reticulum (SR) Ca release have unique features and are distinctly different from ventricular ECC. During ECC the action potential (AP) initiates Ca release from the SR Ca stores primarily through the ryanodine rec…
Sheila Hegde · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $195,480 — PROJECT SUMMARY This K23 application supports Dr. Sheila Hegde, a highly promising cardiac imager and early-stage investigator who is committed to investigating the underlying mechanisms by which physical activity (PA) favorably impacts the risk of heart failure (HF) in late-life. Her long-term goa…