Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
PAUL B FISHER · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $447,407 — Prostate cancer (CaP) is the most commonly diagnosed cancer and the second leading cause of cancer death in men over the age of fifty. Bone is the primary site of metastasis in patients whose CaP progresses beyond organ confinement. The absence of curative therapies for metastatic CaP emphasizes the…
Felipe Diaz-Griffero · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $528,657 — Despite of a great deal of effort by public and private institutions, we don't have a prophylactic vaccine against HIV-1 or an eradication protocol to treat infected patients. Recently, laboratories all over the word have reported an increase in the transmission of HIV-1 strains that are resistant t…
Benoit Gaetan Bruneau · J. DAVID GLADSTONE INSTITUTES · 2024 · $553,585 — SUMMARY The mammalian heart forms early in embryogenesis, and defects in its formation are at the root of congenital heart defects (CHDs), affecting 1–2% of live births. The gene regulatory networks that are disturbed in CHDs have begun to be elucidated from large-scale human genetic studies. Many o…
Gaya K. Amarasinghe · WASHINGTON UNIVERSITY · 2024 · $767,375 — Project Summary/Abstract Bunyaviruses (Order: Bunyavirales) are a growing and diverse family of animal and human pathogens with pandemic potential. With over 300 members and an expanding distribution of mosquito and tick vectors due to climate change, these viruses are responsible for increasing out…
Zongdi Feng · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $518,025 — Summary Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide and can often persist in immunocompromised individuals leading to significant morbidity and mortality. Currently, there are no FDA- approved vaccines or HEV-specific therapy in the U.S. Our long-term goal is to e…
WEIGUO CUI · MEDICAL COLLEGE OF WISCONSIN · 2024 · $408,595 — Atherosclerosis (AS) remains the leading cause of death world-wide and it is often associated with dyslipidemia, oxidative stress and mitochondrial dysfunction. Macrophage is a type of innate immune cell that plays a critical role in the development of AS. Unrestricted uptake of oxidized LDL (oxLDL)…
Shawn Xu · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $368,862 — Chemical cues, such as odors and tastants, are best known to regulate animal behavior. Interestingly, such chemical cues not just regulate behavior, but also other types of critical physiological processes such as longevity. While chemosensory regulation of behavior has been extensively characterize…
Micah Alan Luftig · DUKE UNIVERSITY · 2024 · $457,736 — ABSTRACT Our ultimate goal to define the molecular mechanisms for EBV latency establishment and reactivation in the oral cavity. In this proposal, we aim to characterize how EBV usurps B-cell maturation programs for cell survival and the establishment of a continuum of cell states balancing latency-…
JAMES A WELLS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $345,184 — Project Summary Extracellular proteolysis is a hallmark of cancer. Proteolysis has major functional consequences for remodeling cell surface proteins and matrix including receptor activation and shedding of receptor extracellular domains. Of the more than 600 human proteases, over half are on the ce…
Sushila Maharjan · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $268,500 — Abstract Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels, and represent the leading cause of death worldwide, taking more lives than all forms of cancer combined. An estimated ~18 million people die from CVDs annually, representing 31% of all global deaths, mak…
David Terry Curiel · WASHINGTON UNIVERSITY · 2024 · $1,289,517 — ABSTRACT A variety of gene therapy strategies have been developed to achieve HIV cure. These strategies include genetic methods to render immune cells resistant to infection or to enhance immune effector cell anti-HIV activity. In this latter instance, genetic engineering of B cells has provided a h…
Adrienne M Antonson · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $218,730 — Project Summary Sperm have a remarkable and still unexplained capacity to survive for extended periods in the oviduct, contrary to the strong innate immune response they elicit in the uterus. Following mating, when semen reaches the uterus, sperm interact with uterine epithelial cells to stimulate …
Jason Spence · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $570,518 — ABSTRACT During a recent single cell RNA sequencing analysis of the developing human lung, we identified a cell population characterized by a unique gene expression profile that has not previously been reported in the human or mouse lung. These cells express SCGB3A2/SFTPB/CFTR, but lack markers for …
Adithya Cattamanchi · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $482,508 — Summary Implementation science (ImS) is a branch of research that focuses on the improving the uptake of evidence- based health interventions into real world settings. ImS holds promise for generating new knowledge to close the gap between what we know can optimize health and healthcare and what hap…
Irene A. Stafford · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $654,914 — Abstract The re-emergence in maternal and congenital syphilis (CS) infection in recent years has brought this sexually transmitted infection (STI) to the forefront of policy discussions among federal and state health and human services departments. The recommended tests at birth demonstrate poor sen…
Marianne Goodman · JAMES J PETERS VA MEDICAL CENTER · 2024 — Despite the enrichment of VA suicide prevention services and implementation of the national suicide hotline, Veteran suicide completions occur 20 times per day and suicide attempts numbered over 15,000 in 2012. These data underscore the urgency of developing additional interventions targeting suicid…
PETER GALEN · HEMEX HEALTH, INC. · 2024 · $995,495 — PROJECT SUMMARY Anemia is characterized by low blood hemoglobin levels and has a high prevalence, affecting over one-third of the world's population of about 2.5 billion people. More than 7% of the world’s population carry hemoglobin gene mutations that result in hemoglobin variants, one of which is…
E DOUGLAS LEWANDOWSKI · OHIO STATE UNIVERSITY · 2024 · $769,850 — Project Summary: The pathogenesis of heart failure is linked to systemic metabolic dysfunction, a comorbidity likely involving peripheral organs, and resulting in insulin resistance in patients with and without diabetes. This study focuses on the reciprocal response of adipose tissue to pathological…
Malte Hoffmann · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $245,712 — PROJECT SUMMARY/ABSTRACT Fetal-brain magnetic resonance imaging (MRI) has become an invaluable tool for studying the early development of the brain and can resolve diagnostic ambiguities that may remain after routine ultrasound exams. Unfortunately, high levels of fetal and maternal motion (1) limit…
Qian Dong · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $577,373 — Abstract Multiple myeloma (MM) is the second most common hematologic malignancy (after non-Hodgkin lymphoma) in the U.S. Over the past decade, despite the advent of novel therapies that has improved the life expectancy of patients with MM, MM is still incurable. Patient outcome varies widely with o…