Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
ANTHONY A GRACE · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $705,367 — Stress and the resultant anxiety can provide motivation and prevent reckless behavior. However, when experience in excess can be deleterious. This is particularly true when stressors occur during the peripubertal period, when the brain is undergoing substantial plastic changes. In addition, there ar…
Judy Gichoya · MAYO CLINIC ARIZONA · 2024 · $698,520 — PROJECT SUMMARY Atherosclerotic cardiovascular disease (ASCVD), such as stroke and heart attack, is the leading cause of morbidity and mortality globally, responsible for approximately 19 million deaths annually. Risk assessment is the cornerstone for primary prevention of ASCVD. Pooled Cohort Equat…
Michael John Palladino · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $397,500 — Project Summary Circadian rhythms are a critical component of behavioral and homeostatic function in nearly every organism on Earth, including humans. Neurological diseases such as Alzheimer's, Parkinson's, and epilepsy are often accompanied by disruptions in circadian rhythms. In turn, this can exa…
CRYSTAL FULLER LEWIS · FRIENDS RESEARCH INSTITUTE, INC. · 2024 · $225,981 — PROJECT SUMMARY Black and Latinx people who use opioids (PWUO) bear a disproportionate burden of opioid-related overdose deaths. Racial disparities among PWUO are exacerbated by persistent socioeconomic and structural barriers (e.g., stigma, lack of social support, housing instability) which may be …
Nesha Star Burghardt · HUNTER COLLEGE · 2024 · $226,080 — Project Summary Anxiety- and stress-induced psychiatric disorders affect millions of Americans and often involve social avoidance as a coping strategy for reducing the risk of confronting a stressor. Chronic social defeat stress (CSDS), a widely used rodent model of stress, reliably leads to decreas…
Tatiana V Byzova · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $783,003 — Abstract Alzheimer's disease is the most common dementia characterized by progressive cognitive decline. By estimates, Alzheimer's disease affects more than one-third of the population over 85, posing a substantial socioeconomic burden. There is an apparent lack of understanding of the molecular mec…
Catherine Garrison Velopulos · UNIVERSITY OF COLORADO DENVER · 2024 · $315,000 — PROJECT SUMMARY/ABSTRACT The overall goal of our proposed research is to understand why having health care coverage (or eligibility for health care coverage) is not sufficient to allow equal access to elective surgical care. Despite successful efforts to expand coverage through Medicaid expansion a…
Shaun M Purcell · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $1,321,590 — As the population has aged, there has been a staggering increase in the prevalence and morbidity of cognitive impairment and Alzheimer's disease (AD) related dementias (ADRD): by 2050 the number of people in the U.S. with ADRD will triple to 13.8 million, and associated health care costs will exceed…
Timothy D O'Connell · UNIVERSITY OF MINNESOTA · 2024 · $665,482 — Coronary heart disease (CHD), leading to myocardial infarction (MI) and post-MI heart failure (HF), is a major cause of morbidity and mortality in the US. w3-polyunsaturated fatty acids, like eicosapentaenoic acid (EPA), improve outcomes in CHD and HF, but this is controversial. First, several …
Paolo Palma · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2024 · $983,724 — This will be the first pediatric study with prime-boost HIVIS DNA and MVA-CMDR therapeutic vaccines. Our goal is to develop therapeutic HIV vaccines to reduce the HIV reservoirs in children and youth with HIV. Our scientific premise is that the prime-boost HIVIS DNA and MVA-CMDR vaccines induce cell…
Yuchuan Miao · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $115,579 — How the precise patterns are achieved during development of the human body plan remains obscure due to limited access to human embryos, while elucidating the mechanisms will advance knowledge of human development and contribute to regenerative medicine. The goal of my research is to reconstruct deve…
Robert J. Gropler · WASHINGTON UNIVERSITY · 2024 · $715,437 — A central modern tenet of atherosclerosis is that inflammation is a key driver of the process, and likely provides at least a partial explanation for the excess CVD risk observed even after optimal treatment of traditional risk factors. There is a critical unmet need for imaging tools that accuratel…
saeed jerban · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $120,358 — ABSTRACT: Dr. Jerban is postdoctoral researcher with a multidisciplinary background who is proposing a research entitled “Knee evaluation under mechanical loading by Cones Ultrashort Echo Time MR imaging” through NIH K01 program under the mentorship of Drs. Christine Chung, Samuel Ward, and Jiang Du…
IRINA AGOULNIK · UNIVERSITY OF SOUTH FLORIDA · 2024 · $199,856 — The therapeutics efficacy of an anticancer treatment is often restricted by tumor fibrous tissue and tumor microenvironment. Stromal matrix barriers create a sanctuary for breast cancer, while the prolonged pro-fibrotic stimuli facilitate cancer cell growth and survival by establishing an immunosupp…
Maitreyi Das · BOSTON COLLEGE · 2024 · $296,786 — PROJECT SUMMARY/ABSTRACT Polarized cells in retain their shape in every cell cycle and this is essential to their proper function. Anomalies in polarized cell shape can result in cancer, metabolic disorders, and loss of tissue integrity. Here, we will investigate a long-standing question of how cell…
MARK J SHLOMCHIK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $690,672 — Humoral immune memory is critical for vaccine efficacy and to prevent reinfection. Conversely, dysregulation of humoral immune memory is a likely culprit in autoimmunity and aging. A critical component of humoral im- munity is the memory B cell (MBC). MBC generate more robust responses upon pathogen…
Na Li · BAYLOR COLLEGE OF MEDICINE · 2024 · $560,545 — PROJECT SUMMARY Atrial fibrillation (AF) is the most frequent arrhythmia. Reduced mRNA expression of FK506-binding protein 5 (FKBP5) was recently discovered in a transcriptomic study with AF patient tissues. However, the functions of FKBP5 in heart are unknown. Preliminary studies revealed that card…
Edward Thomas Chouchani · DANA-FARBER CANCER INST · 2024 · $650,788 — PROJECT SUMMARY Succinate, a mitochondrial metabolite, has recently emerged as a major regulator of metabolic physiology and inflammation. Much of this succinate-dependent signaling occurs through its release from cells and subsequent activation of its cognate GPCR, SUCNR1. We discovered that dimini…
Jayme Rose McReynolds · UNIVERSITY OF CINCINNATI · 2024 · $440,054 — Project summary/Abstract Addiction remains a vast problem in the United States and complicating the issue is the lack of FDA-approved medications for the treatment of cocaine use disorder (CUD) making it a critical unmet need. A difficulty in identifying treatment options is that CUD is multi-facete…
Dara E Babinski · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $849,548 — Project Summary Personality disorders are complex and debilitating disorders associated with profound risk for suicide and substantial cost related to long-term intensive care, emergency room visits, and psychiatric hospitalizations. Although traditionally diagnosed only in adults, emerging risk fo…