Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Chuanfu Li · EAST TENNESSEE STATE UNIVERSITY · 2024 · $576,326 — Sepsis represents a life-threatening disorder caused by a dysregulated host response. Sepsis survivors frequently have long-term immune dysfunction that contributes to high mortality from opportunistic infections. Clinical data shows that lactate levels strongly and positively correlate with severit…
HARRIS GOLDSTEIN · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $734,317 — To enable sustained remission of HIV recurrence in the absence of antiretroviral therapy (ART), we aim to develop a strategy to provide people with HIV (PWH) with robust and sustained anti-HIV T cell and antibody responses. We will develop injectable cell-specific lentiviral vector (LV) technology t…
Rachel Marie Bear · EMORY UNIVERSITY · 2024 · $48,974 — PROJECT SUMMARY Astrocytes are the most abundant glial cell in the brain and are essential for neural circuit formation and neuron function. Astrocytes have an indispensable role in the developing brain, yet our fundamental understanding of how astrocytes develop trails our knowledge of neuron devel…
Margaret J Briggs-Gowan · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2024 · $581,159 — ABSTRACT Pregnancy marks a time of increased challenges among families that may be exacerbated by conditions known to enhance stress reactivity and disrupt emotion regulation, such as posttraumatic stress disorder (PTSD). For this already vulnerable population, the 2020 pandemic may constitute a tri…
KENNETH A CHRISTENSEN · CLEMSON UNIVERSITY · 2024 · $66,149 — Project Summary/Abstract Parasite infection with members of the class Kinetoplastea, including Trypanosoma brucei and Leishmania spp., places a tremendous burden on human health, with an estimated ~1.4 million cases of disease recorded in 2015 (World Health Organization). Despite the widespread impa…
Han Zhu · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $158,000 — PROJECT SUMMARY Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing β-cells in the pancreatic islets. Several theories have been proposed to explain T1D pathogenesis including aberrant immune cell activity as well as increased β-cell sensitivity to inflammatory and …
Surojit Sarkar · SEATTLE CHILDREN'S HOSPITAL · 2024 · $645,958 — ABSTRACT Quiescent TCF1Hi stem-like CD8 T cells – functionally poised to rapidly expand and mount a vigorous anti-viral immune response – are critical for mediating effective viral control while avoiding immunopathology during chronic viral infections. The phenotypic, functional and molecular featu…
Zahna Bigham · TUFTS UNIVERSITY BOSTON · 2024 · $48,972 — PROJECT SUMMARY/ABSTRACT Despite improvements in breast cancer incidence and mortality rates in the general population, breast cancer incidence rates in Black women have continued to rise and they exhibit the highest breast cancer mortality rate out of any other racial population. Increased mammogra…
Andrew Eric Aplin · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $502,859 — Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma G protein-coupled receptors (GPCRs) represent the largest family of cell surface proteins involved in signal transmission. GPCRs play key physiological roles and their dysfunct…
Olujimi A Ajijola · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $527,667 — PROJECT SUMMARY/ABSTRACT Cardiac injury predisposes patients to heart failure (HF), and ventricular tachycardia/fibrillation (VT/VF). Development of HF and VT/VF after cardiac injury is tightly linked to sympathetic neural remodeling. Although several medications targeting cardiac sympathetic excess…
Naoki Nakayama · STEADMAN PHILIPPON RESEARCH INSTITUTE · 2024 · $333,971 — ABSTRACT Impairment of articular cartilage function after injury and disease like osteoarthritis (OA), remains a major health problem. One of the major drawbacks of tissue engineering-based therapies for damaged joint articular cartilage is that the cartilaginous repair tissue formed by implanted me…
DANIEL L MINOR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $764,340 — Project Summary The long-term goals of this project are to develop an understanding of the fundamental mechanisms that control the function of K2P potassium channels and to identify, develop, and characterize small molecule, ion channel modulators for the K2P family. K2Ps are a diverse family of pot…
Merlin Nithya Gnanapragasam · CLEVELAND STATE UNIVERSITY · 2024 · $415,031 — Project Summary: The fetal to adult hemoglobin switching around birth involves an expression shift from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle cell anemia and β-thalassemia. Hence, identification of inducers of fetal hemoglobin (HbF) …
Qizhi C. Yao · MICHAEL E DEBAKEY VA MEDICAL CENTER · 2024 — As the risk for pancreatic ductal adenocarcinoma (PDAC) has increased to a higher rate in veterans relative to that in the general population, there is an urgent need to develop effective therapies to treat PDAC for veterans in the VA system. Recently, cancer immunotherapy has shown great promise in…
Christopher Edward Mason · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $662,916 — SUMMARY MDS represents a group of acquired bone marrow failure syndromes arising from hematopoietic stem cells (HSCs). While most MDS patients experience progressive cytopenias, a significant minority (30%) will progress to acute myeloid leukemia (AML); however, the mechanisms that determine whethe…
Emily Ford · UNIVERSITY OF WASHINGTON · 2024 · $189,432 — PROJECT SUMMARY / ABSTRACT Summary of Proposal: This proposal supports a 5-year mentored career development award investigating the tissue-based immune response through the lens of a recent phase 1 immunotherapeutic vaccine trial with the long-term goal of contributing to the development of an effec…
Javeed Ali Shah · UNIVERSITY OF WASHINGTON · 2024 · $200,075 — Project Summary/Abstract. Over one million people died from tuberculosis in 2021. Current treatments are long, costly, and often induce severe adverse effects, but the current vaccine has not been improved in over 100 years. Improved understanding of the host factors that influence Mtb pathogenesis …
Lauren Ashley Cowart · VA VETERANS ADMINISTRATION HOSPITAL · 2024 — This application is to support Dr. Lauren Ashley Cowart, PhD as a VA Research Career Scientist. Dr. Cowart has been VA funded since 2005 and has served as PI on 2 NIH R01 awards (currently funded through 2025), among other intra- and extramural support. Dr. Cowart began her independent career at the…
Jun Chen · VETERANS HEALTH ADMINISTRATION · 2024 — Research in the Chen lab focuses on alleviating the neurological sequelae of traumatic brain injury (TBI) and ischemic stroke, which diminish our veterans’ quality of life. Our goals are to help identify and/or develop pharmacologic agents that can leverage phylogenetically conserved tissue-repair m…
BRIAN P HEAD · VA SAN DIEGO HEALTHCARE SYSTEM · 2024 — Age-related neurodegenerative diseases such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS) are the most common cause of morbidity in the Veteran population. Medical costs for U.S. Veterans of Iraq and Afghanistan could be enormous because of differences between these wars and pr…