NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Terry A Badger · UNIVERSITY OF ARIZONA · 2024 · $613,316 — The use of immune checkpoint inhibitors (ICIs), alone or in combination with other cancer treatments is increasing dramatically with immune-related adverse events (irAEs) common (90%) during ICI treatment. Most irAEs are symptomatic and symptom self-management with timely reporting of moderate or se…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SUSAN SANCHEZ · UNIVERSITY OF GEORGIA · 2024 · $46,329 — Project Summary/Abstract The aim of the Georgia Veterinary Scholars Program (NIH-GVSP) at the University of Georgia College of Veterinary Medicine (UGA-CVM) is to immerse academically talented veterinary students from across the US in cutting edge research, inspire them toward careers in biomedical …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Shunqiang Li · GEORGE WASHINGTON UNIVERSITY · 2024 · $602,262 — Project Summary Cyclin-dependent kinase CDK4/6 inhibitor (CDK4/6i) in combination with aromatase inhibitors is the first-line treatment for ER+ advanced or metastatic breast cancer. Despite CDK4/6 inhibitors significantly improve overall survival of such patients, not all patients respond to these d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Nicholas Varvel · EMORY UNIVERSITY · 2024 · $504,623 — Project Summary Accumulating evidence in humans and in animal models indicates that inflammation of the brain that develops after status epilepticus (SE) may play a determinant role in long-term detrimental consequences, independent of an infection or auto-immune cause. The pathophysiological intera…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SHAI CARMI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2024 · $680,434 — PROJECT SUMMARY Preimplantation genetic testing (PGT) has been utilized for years to avoid implantation of embryos harboring rare monogenic disease-causing alleles or aneuploidies. However, recent progress in complex trait genetics, coupled with the technical ability to generate accurate genome-wid…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
EBONI I LANCE · HUGO W. MOSER RES INST KENNEDY KRIEGER · 2024 · $373,331 — Project Summary/Abstract Sickle cell disease (SCD) is an inherited blood disorder with several neurological and developmental complications. Young children with SCD between 2 and 5 years of age, in particular, have an increased risk for ischemic stroke and silent cerebral infarctions (SCI). SCI are…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jae-Yeon Choi · CURATIX, LLC · 2024 · $300,000 — SUMMARY Invasive fungal infections (IFIs) create significant healthcare and economic burdens as they are responsible for more than one billion infections worldwide each year resulting in more than 1.5 million deaths. Hospital patients who acquire nosocomial IFIs experience longer hospital stays, inc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Elena Martinelli · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $1,180,430 — HIV persists in all treated individuals and in most cases viral rebound occurs promptly upon antiretroviral treatment interruption (ATI). Tissues are major sites of HIV persistence during cART and, notably, the gastrointestinal tract is the first site were rebound is detectable via SIV-end ImmunoPET…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Edward E Luk · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $316,309 — 7. PROJECT SUMMARY/ABSTRACT The chromatin landscape of eukaryotic cells is decorated with landmarks characterized by covalent modifications and variant nucleoprotein structures. Some of these chromatin marks contribute to productive transcription, while others are involved in the establishment and …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ANDREW P. KOWALCZYK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $442,244 — Desmosomes are adhesive intercellular junctions that play critical roles in epidermal homeostasis by mediating robust cell-cell adhesion and by modulating signaling pathways that regulate epidermal differentiation. The importance of desmosomes is highlighted by numerous autoimmune and inherited skin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tod Edward Kippin · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2024 · $461,956 — Many leading questions in neuroscience such as how neurons encode experience, modify behavior, and degenerate, require neural activity to be monitored throughout the brain in living animals. Neuronal activity is tightly linked to an increase in intracellular calcium. Therefore, a cornerstone technol…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
SARAH Louise BOOTH · TUFTS UNIVERSITY BOSTON · 2024 · $742,446 — PROJECT SUMMARY Identification of dietary factors that delay decline in cognitive function has important implications for reducing the burden of Alzheimer’s dementia (AD) and reducing health care costs as the population ages. Inadequate intakes of vitamin K and vitamin D are common among the elderly…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PAUL L FOX · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $474,473 — Project Summary/Abstract Advanced age is the leading risk factor for Alzheimer's disease (AD). Our program is based on a central tenet of geroscience that select pathways and mechanisms are shared between advanced age and chronic disease, and knowledge of one can inform the other. The mTORC1-S6K1 ki…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ce Shang · OHIO STATE UNIVERSITY · 2024 · $657,484 — Project Summary Fifteen states and the District of Columbia have legalized marijuana products for non-medical use, making them accessible to one-third of the US population. Despite having therapeutic effects, marijuana use leads to a wide range of adverse physical and mental effects. Based on approa…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Yiliang Chen · MEDICAL COLLEGE OF WISCONSIN · 2024 · $523,513 — Atherosclerosis (AS) is a chronic inflammatory disease of medium and large arteries and remains the leading cause of death worldwide from its sequelae of heart attack, stroke and limb loss. During AS progression chronic activation of immune cells in the vessel wall, especially macrophages, leads to …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tess K. Drazdowski · CHESTNUT HEALTH SYSTEMS, INC. · 2024 · $201,595 — PROJECT SUMMARY/ABSTRACT The ultimate goal of this Mentored Patient-Oriented Research Career Development Award (K23) is to develop the applicant into an independent investigator prepared to lead ethical, large-scale, and rigorously designed health services research focused on high-risk emerging adul…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Julia E Maxson · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $470,191 — PROJECT SUMMARY ASXL1 is an epigenetic regulatory protein that is frequently mutated in myelodysplastic syndromes and myeloproliferative neoplasms. Mutations in ASXL1 are associated with treatment resistance and poor prognosis. ASXL1 mutations are highly enriched in CSF3R- mutant myeloproliferative …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Stacey J Rizzo · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $764,623 — Project Summary/Abstract Our long-term goal is to identify therapeutic agents that can prevent the pathogenesis of Alzheimer’s disease (AD). The number of AD cases is rising dramatically worldwide, and there is an urgent need to develop new therapies that are more efficacious than the four currently…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Edward Barker · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $760,984 — PROJECT SUMMARY Natural killer (NK) cells provide an immediate defense against viruses and tumors by virtue of their ability to respond to infected or malignant cells without prior antigenic stimulation. This is accomplished through the integration of signals from activating and inhibitory NK cell r…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Meenakshi Arora · UNIVERSITY OF ALABAMA IN TUSCALOOSA · 2024 · $310,226 — Project Summary The etiology of acute kidney injury (AKI), a common disease, can be multifactorial and currently has no FDA- approved drugs for its prevention or treatment. Emerging evidence from laboratory and clinical studies suggests the pathogenesis involves reactive oxygen species (ROS) generat…