Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
PETER SCHUCK · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2022 · $422,189 — The COVID19 pandemic has spawned an unprecedented worldwide collaboration to collect SARS-CoV-2 genome sequences in the GISAID database. It is currently approaching a size of 10 million genomes and is rapidly growing. This genomic database has been instrumental for enhancing our understanding of vir…
Thomas Nutman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $137,557 — In response to the SARS-CoV-2 pandemic, we leveraged our expertise in human T cell cloning to generate SARS-CoV2-specificT cell lines from naive CD4+ and CD8+ T cells of uninfected (SARS Cov2-naive) individuals. To this end, we generated S-specific, M-specific, CMV-specific (controls), CEF-specific …
Iain Fraser · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $72,177 — Cells of the innate immune system, such as dendritic cells and macrophages, constantly patrol host mucosal surfaces and peripheral tissues for signs of infection or injury. Since many people infected with SARS-CoV-2 clear the virus without developing symptoms, aspects of the innate immune response m…
Joel Moss · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $2,503,531 — A. A mixed blood-lymphatic endothelial cell phenotype is Lymphangioleiomyomatosis and Idiopathic Pulmonary Fibrosis but not in Kaposi's Sarcoma and Tuberous Sclerosis Complex:In LAM lungs, the walls of the cystic lesions contain LAM lung nodules, which are composed of neoplastic smooth muscle-like L…
PAUL T WINGFIELD · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2022 · $1,300,893 — In uninfected cells, RNA is transcribed from DNA, processed, and then transported out of the nucleus and translated into protein. In cells infected with HIV-1, the viral RNA genomes must be exported out of the nucleus without being processed so they can be packaged into new viral particles. To do th…
Naoko Mizuno · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $498,022 — We hypothesize that SARS-Cov2 directly interacts with neutrophils as well as platelets through their receptors, and induces a change in platelet morphology, leading to their activation and coagulation. We performed live imaging showing that platelets are directly activated in the presence of purifie…
Nadya Tarasova · DIVISION OF BASIC SCIENCES - NCI · 2022 · $696,075 — Protein-protein interactions control practically all biological processes. Ability to manipulate these interactions is crucial for finding cures for the vast majority of human diseases. Conventional high-throughput screens for small molecule blockers of protein-protein interactions pr…
Mary N. Carrington · DIVISION OF BASIC SCIENCES - NCI · 2022 · $156,177 — The SARS- CoV-2 Omicron variant (B.1.1.529) was the cause of a new surge of infections globally. With as many as 36 substitutions in the viral spike protein and 59 mutations in total throughout its genome, Omicron has been found to evade neutralization by infection- and vaccine-induce…
Devdoot Majumdar · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2022 · $110,871 — The mRNA vaccines against SARS-CoV-2 proved unexpectedly efficacious, but also require a series of booster immunizations to remain protective. Global deployment of these vaccines has been slow, particularly in low- and middle-income countries (LMIC), in part due to the logistical complications assoc…
Aravinda M. DeSilva · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $380,115 — Abstract High-quality recombinant antigens and reliable and accurate SARS-CoV-2 serological assays are urgently needed for surveillance and for defining the immune mechanisms of viral pathogenesis, viral clearance, and protection against reinfection. Core B of the UNC SARS-CoV-2 Serological Sciences…
Taia Wang · STANFORD UNIVERSITY · 2022 · $439,325 — PROJECT 1: SUMMARY As established through decades of research in protective immunity against infectious pathogens, achieving durable immunity against SARS-CoV-2 will require specific functional properties of antibodies, B cells and T cells that need to be defined through detailed repertoire studies.…
Florian Krammer · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $226,649 — PROJECT 1: ABSTRACT Current information indicates that, in persons without cancer, natural infection with SARS-CoV-2 as well as vaccination with COVID-19 vaccine candidates induce antibody responses to the spike protein of the virus which should be protective against future infection. Lung cancer pa…
WILLIAM DEGRADO · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $3,846,686 — PROJECT 3: TARGETING VIROPORINS AND CORONAVIRUS M PROTEIN SUMMARY Coronaviruses express four structural proteins; spike (S), membrane (M), envelope (E) and nucleocapsid (N), which are essential for efficient viral particle formation. We seek to understand and structurally characterize E and M, and t…
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $175,000 — The emergence of the Wuhan new coronavirus (nCoV) initiated efforts to rapidly develop effective medical countermeasures including vaccines and therapeutics against this severe disease. However, there is limited knowledge on polyclonal antibody responses generated following vaccination or nCoV infec…
Jack T. Stapleton · IOWA CITY VA MEDICAL CENTER · 2022 — We propose to characterize SARS-CoV-2 interactions with human T cells and examine how this influences adaptive and humoral immunity. SARS-CoV-2 (CoV2) is the etiologic agent of COVID-19, the third highly pathogenic coronavirus to emerge as a human pathogen since 2000. CoV-2 causes disease by dysregu…
Savita Pahwa · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2022 · $153,500 — This Competitive Revision application for 2019 Novel Coronavirus research is related to the current grant Immune Dysfunction in HIV+ Opioid Users (DA051202) which is investigating influenza vaccine responses in people with HIV (PWH) who have opioid use disorder (OUD). The premise for the funded gran…
Margaret Juliana McElrath · FRED HUTCHINSON CANCER CENTER · 2022 · $1,077,287 — Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for implementation of the first COVID-19 vaccine efficacy trial “A Phase 3, Randomized, Stratified, Observer-Blind, Placebo-Controlled Study to Evalua…
JUAN M SAAVEDRA · GEORGETOWN UNIVERSITY · 2022 · $630,502 — SARS-CoV-2, the virus underlying the current COVID-19 pandemic, not only affects peripheral tissues, it also targets the brain causing microvascular lesions, microhemorrhages and neurological manifestations. The internalization of SARS-CoV-2 is initiated by the binding of the virus spike protein to …
ROBERT A BRODSKY · JOHNS HOPKINS UNIVERSITY · 2022 · $368,356 — The overall goal of this competitive renewal is to define the biology of antiphospholipid antibody syndrome, catastrophic antiphospholipid antibody syndrome and severe forms of COVID-19, and to discover novel biomarkers and therapeutic targets. Complementopathies are diseases where end-organ damage …
Leila Aminova · MIDWEST BIOPROCESSING CENTER, LLC · 2022 · $868,039 — SUMMARY The goal of this project is to develop novel methods to produce sugar building blocks, oligosaccharides, and glycans needed to support and grow R&D related to viral glycobiology at large scale and reasonable prices. This technology will support researchers studying viral pathology, analyses…