NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CHANDRAMOULI KRISHNAN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $211,806 — PROJECT SUMMARY It is commonplace for individuals after anterior cruciate ligament (ACL) reconstruction to shift mechanical de- mands away from their surgical knee and limb. This manifests as diminished knee moments and vertical ground reaction forces in the ACL limb during everyday tasks (e.g., wal…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Pappanaicken Rangasamy Kumar · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $251,250 — PROJECT ABSTRACT Patients with hematological malignancies, and immunocompromised patients are highly susceptible to Candida infection. Based on the immune status of the host, the infections may be mild to life- threatening. The goal is to find novel treatment approaches to give long-term protection …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JONATHON PETER AUDIA · UNIVERSITY OF SOUTH ALABAMA · 2024 · $231,000 — PROJECT SUMMARY/ABSTRACT Our recent publications described pathogenic effects of the Pseudomonas aeruginosa type III secretion system effector ExoU on caspase-1 regulated inflammation. Our new preliminary data indicate that ExoU bypasses the inflammasome to induce a non-canonical form of caspase-1 …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rachel Adele Morello-Frosch · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $403,664 — ABSTRACT - Enriching a Diverse Pregnancy Cohort from the San Francisco Bay Area to Expand Data Access and Individual Results Return on Environmental Exposures to Participant Communities We seek to expand our Chemicals in Our Bodies (CIOB) pregnancy cohort at University of California, San Francisco (…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Matthias Stadtfeld · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $169,500 — Project Summary Mutations affecting the activity or expression of cell type-specific DNA-binding transcription factors (TFs) are a common cause for a range of human diseases and congenital disorders. Despite the established relevance of TF function for human health, the inaccessibility of the develo…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Unsong Oh · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $232,875 — A pathogenic immune response targeting aquaporin-4 (AQP4) causes neuromyelitis optica spectrum disorder (AQP4 NMOSD), a disabling neurological illness that leads to blindness and paralysis. Recent advances in treatment for AQP4 NMOSD have improved its prognosis but are associated with increased risk…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Eva H Clark · BAYLOR COLLEGE OF MEDICINE · 2024 · $80,250 — Project Summary Millions of individuals are infected with Taenia solium (the pork tapeworm) globally. T. solium causes two main types of disease: (1) intestinal disease (“taeniasis”), which is acquired after ingestion of T. solium larvae (“cysticerci”) via infected pork and is often undiagnosed as i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
BENJAMIN K CHEN · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $225,417 — Project Summary The number of physician-scientists in the United States has decreased from its peak of 5% in 1980 to 1.5% today. This decline particularly threatens Pediatrics and child health research where only 12.6% of all MD/PhD program graduates choose residency training in Pediatrics and in I…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Harry William Schroeder · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $185,625 — Project Summary: Millions of antibody sequences from both healthy individuals and patients with a variety of immune-mediated disorders are now freely available to the research community. This has been made possible by support primarily provided by NIAID for the research projects themselves and for t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Molly Leah Tanenbaum · STANFORD UNIVERSITY · 2024 · $115,800 — Project Summary Type 1 diabetes (T1D) is a chronic disease with a demanding self-management burden. Few (<25%) adults with T1D meet ADA-recommended targets for glycemic control, thereby increasing long-term complication risk. Diabetes technology (insulin pumps; continuous glucose monitoring, or CGM)…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Yanxin Pei · CHILDREN'S RESEARCH INSTITUTE · 2024 · $507,610 — Project Summary Medulloblastoma (MB) is the most common malignant brain tumor in children. There are several subtypes of MB, and among them, the GLI2-amplified SHH-MB subtype has the worst prognosis and a poor survival rate; the 5- year survival rate is <30%. Moreover, the GLI2-amplified MBs are non…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Rudi Fasan · UNIVERSITY OF TEXAS DALLAS · 2024 · $389,367 — Metalloprotein catalysts for asymmetric synthesis Project Summary The exquisite chemo-, regio-, and stereoselectivity of enzymes make them attractive tools for organic synthesis, in particular for the generation of optically active synthons and intermediates for the synthesis of pharmaceuticals and …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Shayna Thomas-Jardin · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $76,756 — PROJECT SUMMARY In recent years, there have been groundbreaking discoveries in the identification and therapeutic targeting of the PD-1/PD-L1 immune checkpoint axis. Lung cancer cells express high levels of Programmed Death Ligand 1 (PD-L1), a critical ligand for PD-1 on T cells. The PD-1/PD-L1 inte…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Samuel R Denmeade · JOHNS HOPKINS UNIVERSITY · 2024 · $181,813 — Prostate cancer patients acquire resistance to standard-of-care strategies progressing to advanced disease and resulting in 350,000 yearly deaths. As acquired resistance is mediated by increased androgen receptor (AR) expression, we are developing a “Bipolar Androgen” therapy (BAT) cycling serum tes…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JESSE C. DEAN · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — After a stroke, deficits in the control of standing balance contribute to a decreased quality of life, decreased functional mobility, and an increased risk of falls. Unfortunately, rehabilitation methods that have successfully reduced fall incidence in older adults (e.g., targeted strengthening exer…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Karina Alvina · UNIVERSITY OF FLORIDA · 2024 · $295,048 — Project Summary The sense of smell is essential for maintaining full human health and quality of life. It plays an important role in the detection of environmental dangers as well guiding decisions such as what foods to eat. However, olfactory processing is influenced by the physiological state of a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Sharad Ramanathan · HARVARD UNIVERSITY · 2024 · $469,127 — Abstract The long term goal of this proposal is to quantitatively understand how gene regulatory networks (GRNs) generate the diversity of cell types during the development of the human brain. The focus of this proposal is to determine how key progenitor cell types that are uniquely enriched in huma…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Franziska Bleichert · YALE UNIVERSITY · 2024 · $321,155 — Project Summary The survival of living organisms depends on the timely and accurate duplication of chromosomal DNA. In all domains of life, the onset of DNA replication (or initiation) relies on dedicated initiator proteins that bind genomic sites, termed replication origins, and help load replicati…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Daniel Ryland Southworth · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $402,556 — PROJECT SUMMARY/ABSTRACT Protein disaggregation and turnover are essential for protein homeostasis (proteostasis) and cell viability. Malfunction occurs during cell stress and aging, accelerating deleterious protein aggregation and amyloid formation. Improved mechanistic understanding is critical fo…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
DEBRA H BRANDON · CHILDREN'S HOSPITAL OF WISCONSIN · 2024 · $582,612 — ABSTRACT Early developmentally-based behavioral intervention has well-established positive effects and is recommended as the standard of care to support early brain maturation, health, and development. However, few neonatal intensive care units (NICUs) provide this early intervention. H-HOPE (Hospit…