Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Nalinikanth Kotagiri · UNIVERSITY OF CINCINNATI · 2024 · $497,870 — Project Summary Adoptive cell transfers constitute a new paradigm in cell-based therapeutics with wide-ranging applications from neurodegenerative, cardiovascular, autoimmune disorders as well as cancer. Autologous lymphocytes from the patient are genetically engineered to express receptors to speci…
Donald G Phinney · UNIVERSITY OF FLORIDA · 2024 · $827,141 — Project Summary Mesenchymal stem/stromal cells (MSCs) are under intensive investigation as therapeutics for treating a diverse array of human diseases, and while some trials have demonstrated significant patient benefits, most have yielded suboptimal outcomes. Currently, most clinical trials employ …
Sun Young Lee · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $476,894 — Abstract Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agent monotherapy is the current mainstay for treating neovascular age-related macular degeneration (NVAMD). Despite its vision saving benefit, some patients fail to respond to the treatment because of insufficient the…
MANOJ K PATEL · UNIVERSITY OF VIRGINIA · 2024 · $387,045 — Epilepsy is a major economic and personal burden for the American public, affecting over 3 million Americans (1-2% of the population) with over 200,000 new cases diagnosed each year. There is no cure for epilepsy. Seizures can only be suppressed using antiepileptic drugs. Unfortunately, these drugs …
Emanuela Marina Bruscia · YALE UNIVERSITY · 2024 · $618,680 — PROJECT SUMMARY Macrophages (MΦs) kill microorganisms, engulf dead cells and debris, and regulate the immune response. They are thus gatekeepers of tissue health, including the lungs. The lung-tissue-resident MΦs (TR-MΦs) are the interstitial and alveolar MΦs, which have complementary but distinct f…
Sidharth Tyagi · YALE UNIVERSITY · 2024 · $31,570 — Project Summary: Targeted degradation of NaV1.8 as a therapeutic strategy for pain. Chronic pain is a massive global health burden, and therapeutic options for pain are limited and have a spectrum of adverse effects. Alternative treatments for pain that are specific, effective, and non-addictive are…
Dax A Hoffman · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2024 · $2,312,037 — Kv4.2 is an activity-dependent Ube3A substrate and contributes to synaptic plasticity and cognitive flexibility in Angelman syndrome Angelman syndrome (AS) is a severe neurodevelopmental disorder affecting 1 in 20,000 people, caused by loss of function of imprinted genes on chromosome 15q11–13 or m…
Samuel Matthew Young · UNIVERSITY OF IOWA · 2024 · $207,567 — The diversity of information encoding by neuronal circuits is regulated by the magnitude and location of Ca2+ entry though voltage-gated Ca2+ channels (CaV). In the mammalian central nervous system, the CaV2.1 channel is the critical subtype for CNS function since it is the most efficient CaV2 subty…
Matthew Reed Steinhart · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $34,293 — ABSTRACT Neurofibromatosis Type 2 (NF2) is a genetic condition in which specific types of tumors form in various locations throughout the body. Though the majority of these tumors grow slowly, the location of certain tumors can cause significant dysfunction. One of these tumor types grows on the ves…
Jose Maria Martinez-Navio · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $762,712 — Project Summary/Abstract The poor immunogenicity of the HIV envelope spike and its vast variability represent major obstacles for efficient elicitation of protective anti-HIV antibodies. One promising strategy is to bypass the immune system and deliver already known and well-characterized potent and…
Merav Socolovsky · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $494,603 — Project Summary Protein synthesis and ribosome biogenesis are the two most energy -intensive processes in a cell, resulting in their regulation through tight controls. EpoR, a member of the cytokine receptor superfamily, and its downstream mediator Stat5, are essential for erythropoiesis. The curren…
Alexander Dickson · MICHIGAN STATE UNIVERSITY · 2024 · $347,124 — Project Summary Biology at the nanoscale is driven by molecular recognition. Cells are lined with receptors that recognize a myriad of biomolecules and transmit signals to the cell interior. This forms the basis of cell-cell communication that allows multicellular organisms to thrive. An understandi…
VAHRAM HAROUTUNIAN · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $1,267,500 — PROJECT SUMMARY Alzheimer’s disease (AD) stands out as notable in two respects––in not having a cure and in affecting women more than men. While declining estrogen has been thought to underpin post–menopausal AD, there is a clear clinical correlation of AD with rising levels of follicle–stimulating…
Kartik Chandran · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $558,501 — The nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe, lethal hemorrhagic disease. CCHFV is the most prevalent tickborne virus that causes human disease and is endemic in countries across Europe, Asia, and Africa. No FDA-approved countermeasures are currently available for this …
Xiaohong Lu · LOUISIANA STATE UNIV HSC SHREVEPORT · 2024 · $506,052 — Project Summary/Abstract Neuropathological interactions between COVID-19 and ADRD suggest shared molecular and cellular mechanisms. A recent case series study revealed striking cutaneous Lewy pathology (phosphorylated α- synuclein) in Long-COVID Postural orthostatic tachycardia syndrome (POTS) patie…
Magnus Adrian Gero Hoffmann · J. DAVID GLADSTONE INSTITUTES · 2024 · $472,500 — Project Summary/Abstract The COVID-19 pandemic represents the 3rd outbreak caused by zoonotic transmission of a beta-coronavirus (beta-CoV) in the last 20 years. Hence there is an urgent need for new vaccine strategies to control the ongoing pandemic and prevent future CoV outbreaks. mRNA vaccines h…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $820,801 — Abstract. The UNC Center for Excellence in SARS-CoV2 Serologic Research uses basic and applied research strategies to improve our understanding of the molecular and cellular mechanisms driving serological and humoral immune responses after SARS-CoV2 infection. Our overall goals are to 1) characteriz…
Mark M Painter · UNIVERSITY OF PENNSYLVANIA · 2024 · $76,756 — Project Summary/Abstract CD8 T cells are critical to the adaptive immune response to viral pathogens. When neutralizing antibodies are insufficient to prevent viral infection outright, virus-specific memory CD8 T cells can rapidly kill infected cells and limit the severity of infection. This has rec…
Syed Saif Hasan · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $247,750 — PROJECT SUMMARY The spike (S) protein decorates the surface of coronavirus (CoV) particles such as SARS-CoV-2 and enables CoV's to enter and infect host cells. The S protein is the immunogen in genetic and subunit vaccines against COVID-19, which were critical in controlling the COVID-19 global pand…
PETER Jay NOVICK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $465,901 — Project Summary The endoplasmic reticulum (ER) undergoes autophagic degradation in response to the accumulation of aggregated proteins within its lumen or in response to starvation. We have proposed that in yeast, actin assembly at sites of contact between the cortical ER (cER) and endocytic pits is…