Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Kenneth A Matreyek · CASE WESTERN RESERVE UNIVERSITY · 2024 · $201,250 — PROJECT SUMMARY Viral spillover from animal reservoirs into humans can decimate public health systems and cripple the world economy, as evident with the current SARS-CoV-2 pandemic. Continued wildlife habitat destruction, human expansion, and routine global travel keep increasing the likelihood tha…
CAMERON F ABRAMS · DREXEL UNIVERSITY · 2024 · $797,785 — PROJECT SUMMARY The HIV-1 envelope glycoprotein spike (Env) mediates viral entry into target cells. Because Env is the only viral protein on the virion surface, it is central to the development of potential vaccines and small-molecule entry inhibitors. Env is a uniquely flexible molecular machine, a…
Deyu Fang · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $697,517 — Abstract Biomarker-guided treatment is key to improve outcomes of many diseases. The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis due to lagged vaccination and inefficient control of the virus, which has caused over 253 million c…
Weishan Huang · LOUISIANA STATE UNIV A&M COL BATON ROUGE · 2024 · $228,149 — Project Summary/Abstract SARS-CoV-2, the etiological pathogen of COVID-19, has resulted in a pandemic. There remains an urgent need for innovative technologies which facilitate the development of affordable antiviral precision medicine. SARS-CoV-2 is an enveloped virus, and the structure of the tri…
Pia S Pannaraj · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $789,208 — PROJECT SUMMARY COVID-19 cases and hospitalizations in children have increased dramatically worldwide. Although most COVID- 19 is mild in children, severe illness and post-infectious complications can occur. We and others have found that children are an important source of household and community tr…
Megan A O'Connor · UNIVERSITY OF WASHINGTON · 2024 · $353,000 — PROJECT SUMMARY/ABSTRACT COVID-19 vaccination is safe, immunogenic, and durable in individuals with treated and virally suppressed HIV infection but is less immunogenic in immunosuppressed individuals and those with unsuppressed HIV infection. The rollout of COVID-19 vaccines is still limited in cou…
BARSANJIT MAZUMDER · CLEVELAND STATE UNIVERSITY · 2024 · $185,625 — Adopted folding of the RNA elements within the genomes of RNA viruses allows binding of host and viral proteins and plays an essential role in host-virus interactions. However, the mechanistic insights on how these RNA elements could sense the transduced signals from host cells are lacking for SARS-…
Siyuan Ding · WASHINGTON UNIVERSITY · 2024 · $194,375 — Rotavirus (RV) is a major etiological cause of severe gastroenteritis and diarrhea worldwide, resulting in the death of more than 200,000 children each year. Current RV vaccines have limited efficacy in endemic countries and no direct antivirals are available. Our overall objective is to better unde…
KATHERINE D MCREYNOLDS · CALIFORNIA STATE UNIVERSITY SACRAMENTO · 2024 · $106,500 — PROJECT SUMMARY/ABSTRACT The current COVID-19 pandemic has resulted in millions of infections and over 2 million deaths worldwide since SARS-CoV-2 emerged in Wuhan, China in December of 2019. This pandemic has revealed a significant treatment gap in the ability to minimize the morbidity and mortali…
Ya-Wen Chen · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $638,230 — Project Summary In early 2020, a new virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), generated headlines due to its unprecedented rate of transmission. SARS-CoV-2 caused the first reported cases of coronavirus disease 2019 (COVID-19) in December 2019 and continues to spread wor…
Catarina E Hioe · JAMES J PETERS VA MEDICAL CENTER · 2024 — Project Summary/Abstract This application is to request a renewal of the BLR&D Research Career Scientist (RCS) award for Dr. Catarina Hioe. Dr. Hioe is a Research Health Specialist (GS14 Step 6) at the James J. Peters VA Medical Center (JJP VAMC), Bronx, NY, and a tenured Professor of Medicine at t…
Amit Praful Khandhar · HDT BIO CORPORATION · 2024 · $981,917 — Project Summary/Abstract A key requirement for HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope (Env) spike. The BG505 SOSIP.664 gp140 soluble timer is engineered to display conformational epitopes recognized by several bNAbs but not …
MARK L DELL'ACQUA · UNIVERSITY OF COLORADO DENVER · 2024 · $565,359 — Plasticity in the hippocampus leads to persistent changes in synaptic structure and function that underlie learning and memory. Intracellular Ca2+ signaling pathways activated downstream of NMDA receptors (NMDAR) and L-type voltage-gated Ca2+ channels (LTCC) contribute to changes synaptic function t…
Catarina E Hioe · JAMES J PETERS VA MEDICAL CENTER · 2024 — Project Summary/Abstract The COVID-19 pandemic, which is caused by SARS-CoV-2, a novel coronavirus first detected in November-December 2019, has inflicted millions of deaths worldwide. In the US, the outbreak is affecting millions of lives. The VA hospitals, including the James J. Peters VA Medical…
Niraj Tolia · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $164,252 — SARS-CoV-2 is a serious global threat that has been met with an unparalleled research response. Scientific understanding of SARS-CoV-2 is already deeper than most pathogens and it is growing rapidly. This knowledge provides an opportunity to design a vaccine that goes beyond traditional methods. …
Masashi Tabuchi · CASE WESTERN RESERVE UNIVERSITY · 2024 · $386,030 — Project Summary/Abstract The idea that information processing depends on neuronal firing rate (rate coding) has long been a central dogma in neurobiology. However, other non-canonical coding schemes (temporal and “analog” codes) have been proposed to carry meaningful information and be more computat…
Hsien Wei YEH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2024 · $249,000 — úú PROJECT SUMMARY/ABSTRACT Delivering diagnostic services at the point-of-care (POC) can improve the quality of healthcare in clinics, in emergency settings, or at home, which can potentially ease hospitals’ burden, for instance, during the COVID- 19 pandemic. Precision and personalized medicine re…
DUXIN SUN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $513,210 — Various nanoparticles (NPs) have been used for delivery of small antigens, which have limited viral mimic features and are more efficacious than soluble antigens in stimulating B-cell immunity. However, these traditional NPs lack characteristics of virus “spiky capsid protein peplomer”, e.g. spiky a…
Vaughn Vasil Smider · APPLIED BIOMEDICAL SCIENCE INSTITUTE · 2024 · $921,025 — Abstract Targeted therapeutic agents range in size from very small organic molecules (100’s of Da) to protein-based molecules like monoclonal antibodies (~150,000 Da). Small disulfide bonded peptides have evolved in many species, including plants and animals, to have ideal pharmacological properties…
Krishna M.G. Mallela · UNIVERSITY OF COLORADO DENVER · 2024 · $234,000 — Project Summary/Abstract The COVID-19 pandemic has affected over 690 million people worldwide and caused 6.9 million deaths. Although the recent variants are less infectious and cause lower mortality than earlier ones, diagnosed active cases are as high as 20 million worldwide. SARS-CoV-2 spike prot…