Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Chandan Guha · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $582,293 — Abstract Radiation-Induced Immune Dysfunction (RIID) is a critical component of both acute and delayed effects of radiation exposure, which causes a multi-organ failure (MOF) syndrome, operationally divided based upon timing of clinical manifestations, as acute radiation syndrome (ARS) and delayed e…
Adrianus CM Boon · WASHINGTON UNIVERSITY · 2024 · $566,583 — PROJECT SUMMARY SARS-CoV-2 has led to unprecedented disruptions to society, killing more than 6 million people worldwide. It is a respiratory virus whose main mode of transmission is via respiratory droplets and aerosols. Social distancing and vaccines have greatly decreased the rate of infection an…
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2024 · $816,248 — Project Summary The first critical step for enveloped viruses, such as HIV-1, to enter host cells is viral membrane fusion. Viral fusion proteins are fascinating protein folding machineries capable of adopting completely different conformations during the fusion process; they are also important vac…
Peter B. Gilbert · FRED HUTCHINSON CANCER RESEARCH CENTER · 2022 · $1,011,819 — Project Abstract: This proposal outlines the scientific agenda for the Leadership and Operations Center of the HIV Vaccine Trials Network (HVTN), the collaboration of physician scientists at 64 clinical trial sites in 15 countries on 4 continents dedicated to developing globally effective vaccines f…
DEAN R MADDEN · DARTMOUTH COLLEGE · 2022 · $230,023 — The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards lo…
Bill William Kiosses · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2022 · $514,425 — ABSTRACT The La Jolla Institute for Immunology (LJI) is a premier immunology research institute in the US whose 20 principal investigators are supported by ~$39 million in NIH grants and contracts. At LJI, we study the behavior of immune cells in diseases prominent in the US and around the world, in…
ARUN K GHOSH · PURDUE UNIVERSITY · 2022 · $750,974 — Abstract The main objective of this project is to advance our extensive preliminary results and develop novel protease inhibitor drugs for the effective treatment of COVID-19. The COVID-19 pandemic, caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), eme…
STEFFANIE A. STRATHDEE · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $379,961 — In response to NOT-OD-22-159, this project will leverage an ongoing cohort of people who inject drugs (PWID) in the U.S.-Mexico border region to study the epidemiology of monkeypox virus (HMPXV) to inform prevention interventions to diagnose and treat HMPXV and curtail transmission. Although it is w…
CLIFFORD JAMES ROSEN · MAINEHEALTH · 2022 · $348,925 — ABSTRACT The National Covid Cohort Collaborative (N3C), created by the National Center for Advancing Translational Sciences (NCATS) and the National Center for Data to Health (Cd2H) have created a centralized national database and analytic platform for scientists to use to study COVID-19 and identif…
D. Rebecca Prevots · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $11,997 — Background Prior research has shown variability in household secondary attack rates (SAR) and transmission risks of SARS-CoV-2, which remains poorly understood. To address these questions, we conducted a household serologic study nested within a larger prospective cohort study of SARS-CoV-2 in Cost…
Jeffrey Reece · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2022 · $521,049 — The mission of the National Institutes of Health (NIH) is to seek fundamental knowledge about the nature and behavior of living systems and to apply that knowledge to enhance health, lengthen life, and reduce illness and disability. As part of the NIH, the National Institute of Diabetes and Diges…
Mario Borgnia · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $1,842,598 — The NIEHS Cryo-EM Core continues to lead the deployment and to promote the adoption of techniques in cryo-electron microscopy in the region. Over a dozen peer reviewed articles in high impact journals during FY2022 are a clear indication. The Core has played an important role in the intramural respo…
David Wang · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2022 · $892,381 — Specific aim 1: To develop in vitro 3D brain organoid models derived from human adult peripheral CD34+ cells to study neural development and degeneration and infectious diseases involving human brain. We expended our capability to derive 3D neural organoids to mimic human brain. Using improved clear…
Alison Motsinger-Reif · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $999,804 — There have been major efforts in this project in both the public health applications of PVI, and in the building and dissemination of the software tools that enable expanded impact of the visualization and contextualization tools. Public health efforts: The Centers for Disease Control and Preventi…
Zhiyong Lu · NATIONAL LIBRARY OF MEDICINE · 2022 · $1,791,061 — Over the last decade, the online search for biological information has progressed rapidly and has become an integral part of any scientific discovery process. Today, it is virtually impossible to conduct R&D in biomedicine without relying on the kind of Web resources developed and maintained by the …
Connie Schmaljohn · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $43,684,432 — In FY22, the IRF-Frederick focused most research efforts on SARS-CoV-2/COVID-19 studies. This included in vitro testing of antibody therapeutics and development of nonhuman primate and hamster animal models of COVID-19 to support medical countermeasure efficacy testing and pathogenesis experiments. …
Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $6,317,338 — The NIEHS Clinical Research Branch has continued to expand its scope of support for clinical and translational studies. The NIEHS Clinical Research Unit (CRU) has recorded over 11,000 patient encounters with over 95% patient satisfaction. Additional staff have been hired to support CRU functions. …
Philip Anfinrud · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2022 · $484,048 — The Covid-19 pandemic proved quite disruptive to our core research program, and led to collaborative studies that focused on mechanism of disease transmission via aerosols, such as SARS-CoV-2. Our pioneering studies with Dr. Ad Bax to visualize speech droplets via laser scattering and evaluate their…
Donald Lo · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $1,450,000 — In collaboration with NIH and external academic researchers and companies, we have developed assays that predict antisense oligonucleotide toxicity that can be applied across multiple projects. To date, we have engaged in productive partnerships across various therapeutic areas related to ASO therap…
Elodie Ghedin · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $1,658,114 — Host response to influenza infection is a complex trait that involves entire host-pathogen interaction networks of RNA transcripts, proteins, and metabolites that have an impact on cellular, tissue, and whole-organism behaviors, which ultimately define both the risk and severity of infection. This p…