Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Menghang Xia · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $600,500 — The Tox21 programs federal partners include the Environmental Protection Agency (EPA), the Food and Drug Administration (FDA) and NIH, with leadership from NCATS and the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS). These agencies work together…
Geoffrey Mueller · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $749,624 — I. Origins of Allergic Disease Over 100 million people worldwide suffer from birch pollen allergy. However, identification of molecular determinants driving the allergic responses to Bet v 1, the major birch pollen allergen, remains elusive. Using recently-developed high-throughput approaches, bo…
RICHARD DOUGLAS FIELDS · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2022 · $1,266,256 — Our long-standing interest is in neural plasticity, but we are especially interested in the involvement of glial cells in nervous system development, learning & cognition. Glia are brain cells that do not fire electrical impulses, but they communicate by releasing neurotransmitters. This enables g…
Matthew Wheeler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $101,675 — With the increasing complexity of large datasets, the development of novel statistical techniques that can create informative analyses, which allow scientists and decision makers, to leverage the richness of the data source is needed. This research seeks to develop methodologies that extract meanin…
Nicole Doria-Rose · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $100,000 — During the past years, the Virology Laboratory has collaborated with other intramural NIAID labs and other external collaborators to develop a pseudovirus neutralization assay and an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). For the neutralization assay, w…
Gary Felsenfeld · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2022 · $396,360 — Chromatin structure and architecture. Histone proteins package and condense genomic DNA into chromatin within the cell nucleus. Proteins such as the CCCTC binding factor (CTCF) help direct chromatin higher-order organization through passive and active mechanisms by imposing topological constraints…
HAN WEN · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $1,270,498 — This project is the main effort of my lab for the last year. On the clinical application front, we developed ultrahigh resolution (UHR) CT and quantitative CT (qCT) technologies that are used in 4 clinical protocols: Protocol 96-H-0100, LAM and other rare cystic lung diseases, PI Joel Moss, NHLBI …
Reed Johnson · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $734,780 — Viruses of the Coronaviridae family are enveloped viruses that possess a large (30kb), single-stranded, positive sense, RNA genome that infect a large number of mammals (alpha and beta coronaviruses) and birds (gamma coronaviruses). Four different seasonal coronaviruses (two alpha coronaviruses, 229…
Frank Maldarelli · DIVISION OF BASIC SCIENCES - NCI · 2022 · $635,273 — Fundamental gaps in our understanding of HIV reservoirs preclude a precisely targeted approach to eradication. HIV is neither eliminated nor often controlled by the human immune system, and the immunologic defect(s) responsible for this lack of control are unknown. We are conducting s…
Gehan Devendra · UNIVERSITY OF HAWAII AT MANOA · 2022 · $462,752 — PROJECT SUMMARY/ABSTRACT Nearly one third of individuals who recover from acute COVID-19 will have chronic symptoms, so called ‘Post- Acute Sequelae of SARS-CoV-2’ infection (PASC). Among individuals with PASC, pulmonary complications such as persistent dyspnea and chronic cough are common. Although…
RICHARD G WUNDERINK · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $243,834 — PROJECT SUMMARY CORE B Lower respiratory tract infections cause nearly 80% of deaths from infectious diseases in the US, and respiratory viruses, such as influenza and SARS-CoV-2, are increasingly recognized as common causes of severe community-acquired pneumonia (CAP). As mortality from severe CAP …
KAREN M RIDGE · NORTHWESTERN UNIVERSITY AT CHICAGO · 2022 · $526,012 — PROJECT SUMMARY PROJECT 1 Severe viral pneumonia, due to influenza A virus (IAV) damages the lower respiratory tract to cause acute respiratory distress syndrome (ARDS). The persistence of respiratory failure in patients with ARDS is a consequence of persistent inflammation and the failure of normal…
Kristen A Johnson · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $2,503,204 — SUMMARY The emergence of SARS-CoV-2 into a worldwide pandemic has accounted for > 4,800,000 deaths worldwide, has exposed the dearth of antiviral therapeutics needed to control, treat and prevent infections from viruses of pandemic potential. Despite the successful development and deployment of mult…
TED ROSS · UNIVERSITY OF GEORGIA · 2022 · $61,062 — The Georgia University Research Foundation to support the National Cancer Institute's multi-site study seeking to evaluate antibody responses to SARS-CoV-2 virus in high risk populations including health workers, first responders, frontline worker (e.g. grocery store employees) and disproportionate…
THOMAS DENNY · DUKE UNIVERSITY · 2022 · $1,787,600 — The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is to increase basic knowledge of the pathogenesis and transmission of the human immunodeficiency virus (HIV), support the development of therapies for HIV…
KANECIA ZIMMERMAN, MD · DUKE UNIVERSITY · 2022 · $999,956 — For the last 25 years the scientific community, including academia, the National Institutes of Health (NIH), the Food and Drug Administration (FDA) and the pharmaceutical industry have worked to improve the knowledge of medications used in children. The responsibility for the implementation and o…
KEVIN NEWELL · LEIDOS BIOMEDICAL RESEARCH, INC. · 2022 · $3,893,764 — This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population (aged 0-21 years), including coronavirus disease 2019 (COVID-19) and multisystem in…
AMANDA LYNSEY JONES · SEATTLE CHILDREN'S HOSPITAL · 2021 · $93,216 — SUMMARY OF FUNDED PROJECT AND SUPPLEMENT PROJECT Our currently funded SEPA project creates NGSS-aligned curriculum for students in grade eight at under- resourced urban and rural middle schools with high populations of financially disadvantaged and minority students. We are assessing the short-term …
Joshua Glenn Petrie · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $60,002 — PROJECT SUMMARY / ABSTRACT The COVID-19 pandemic has strained hospital capacity and led to shortages in personal protective equipment and testing supplies. This is particularly concerning because the SARS-CoV-2 virus that causes COVID-19 has resulted in notable healthcare associated outbreaks, as ha…
James D Weger · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2021 · $230,567 — Project Summary/Abstract Chikungunya virus (CHIKV), an NIAID category B pathogen, causes a debilitating arthritic disease that can last for years. A massive outbreak of CHIKV occurred throughout the Americas in 2013, with an estimated 39.9 million people infected. Closely related viruses include Ro…