Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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ANBU DEVASAHAYAM · 2021 · $91,235 — The Clinical Product Center under contract, provides Investigational Product Services for all DAIT-funded and/or sponsored clinical research programs and other NIAID-funded clinical trials as needed. Studies to be supported encompass a broad range of immune-mediated & rare diseases, including: (i) a…
ETHAN DMITROVSKY · LEIDOS BIOMEDICAL RESEARCH, INC. · 2021 · $85,668,587 — The purpose of the National Cancer Institute’s SARS-CoV-2 Serological Sciences Network (SeroNet) is to study the immune response to COVID-19 by developing and deploying serological assays of the highest specificity and sensitivity, expanding the national testing capacity for SARS-CoV-2 antibodies, a…
Jason W. Botten · CELDARA MEDICAL, LLC · 2021 · $299,916 — Summary Accelerating emergence and re-emergence of a wide array of viral epidemics has been a deadly feature of the 21st century. Potent or even effective therapies are rarely available to combat these diseases, and in general, the world remains unprepared to manage future outbreaks. The most recent…
Arantzazu Eiguren Fernandez · AEROSOL DYNAMICS, INC. · 2021 · $256,005 — Project Summary While knowledge of the transmission modes for respiratory pathogenic viruses is critical, understanding their transmission mechanisms is hampered by existing sampling methods. Commonly used bioaerosol samplers have low collection efficiencies for particles < 0.3 m (e.g., influenza …
MANUEL R AMIEVA · STANFORD UNIVERSITY · 2021 · $1,559,276 — Stanford/UNC Biomimetic U19 Research Center PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW Infectious diseases continue to pervasively afflict global health and socioeconomic stability despite substantial prevention and treatment initiatives. Respiratory and gastrointestinal pathogens rank amongst the m…
OFER LEVY · BOSTON CHILDREN'S HOSPITAL · 2021 · $800,481 — IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC) Project summary In December 2019, a cluster of respiratory illness in Wuhan, China defined the onset of a global pandemic involving a novel coronavirus (SARS-CoV-2) with associated respiratory di…
CRISTIAN APETREI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $690,235 — Abstract A coronavirus pandemic is currently in progress and a tremendous effort for developing effective vaccines to curb it is currently being made. Adenovirus (Ad)-based vaccines are in the lead in the clinical trials, and it is to be expected that at least one vaccine formulation will comprise o…
ALAN R HAUSER · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $749,891 — SARS-CoV-2, the cause of the COVID-19 pandemic, emerged from Wuhan, China, and rapidly spread around the world. A feature of the pandemic has been the repeated emergence of SARS-CoV-2 clades and variants of concern, some of which have been shown to have enhanced transmissibility. Other aspects of th…
Sally Lynn Hodder · WEST VIRGINIA UNIVERSITY · 2021 · $3,672,786 — Since the emergence of the novel coronavirus (SARS-Cov-2) in the United States, more than 33 million cases have been confirmed, and the death toll has climbed to over 600,000 persons. The Institutional Development Award Program (IDeA) Clinical and Translational Research Centers (CTRs) are located in…
Matteo Porotto · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $561,162 — Measles (MeV) causes disease worldwide despite efforts towards eradication by vaccine, largely because it is spread so readily between people. Acute MeV infection causes immune amnesia, resulting in increased susceptibility to other infectious diseases. In addition, rare but severe neurological comp…
JACK LENZ · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $84,000 — Abstract/Summary Viruses play a role in 10 to 20% of human cancers. Tying specific viruses to human cancers remains a fundamental biomedical and technological problem. One virus family, the human papillomaviruses (HPVs), comprises over 225 known types and causes lesions ranging from benign warts to …
ELLEN L BURNHAM · UNIVERSITY OF COLORADO DENVER · 2021 · $49,566 — Project Summary The proposed supplement will augment an established R24 Alcohol Research Resource, known as CoPARC (Colorado Pulmonary-Alcohol Research Collaborative), that has served as a human participant and patient biorepository supporting translational investigations at the intersection of alco…
MATTHEW Lawrence SPRINGER · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $80,301 — PROJECT SUMMARY This urgent competitive revision will support a rapid response effort to determine if cigarette smoking-induced changes in airway epithelium that make it more susceptible to SARS-CoV-2 infection also result from marijuana smoking (smoke without nicotine), or from use of electronic ni…
AKSHAY SOOD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2021 · $958,041 — ABSTRACT There are limited studies on the spread of SARS–CoV-2 infection in rural essential workers. This gap-in-knowledge must be addressed to develop and implement novel pandemic strategies to keep open rural essential workplaces, such as coal mines. The long-term goal of the study is to mitigate …
Eida Maria Castro · PONCE SCHOOL OF MEDICINE · 2021 · $1,427,381 — PROJECT ABSTRACT In Puerto Rico (PR), the first COVID-19 case was confirmed early March 2020. To date cases have exponentially increased partly due to the lifting of locked-down restriction by the PR government, limited COVID-19 testing, and contact tracing. Puerto Ricans living on the island are pa…
William Messer · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $191,724 — PROJECT SUMMARY Yellow fever virus (YFV) is the prototype flavivirus and is historically the most important arthropod-borne viral pathogen of humans worldwide with ~200,000 infections annually and a mortality of ~50% in those who develop severe symptoms. YFV is endemic throughout Africa and South Am…
Deborah J Donnell · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $978,683 — Abstract The proposed research, CoVPN 5002, will directly contribute to preparedness for SARS-CoV-2 vaccine and other COVID-19 prevention and treatment studies by determining the prevalence of SARS-CoV-2 infection and seroprevalence among samples of individuals at elevated risk as well as the genera…
Ana Fernandez-Sesma · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $152,665 — The COVID-19 pandemic is the most important health challenge to the US population within a century. Most epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults. Inadequate information regarding the infection burden in children is available…
HANA M EL SAHLY · BAYLOR COLLEGE OF MEDICINE · 2021 · $1,756,259 — Abstract Currently, the United States (US) has far more confirmed COVID-19 cases than any other country. The US epidemic is remarkably heterogeneous, with many cities and communities experiencing a disproportionately high disease burden and mortality. For example, at present, Miami, Minneapolis, Hou…
Benjamin F Arnold · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $781,015 — Enteric pathogen infections are a leading cause of the global disease burden, with the largest burden among children in low-resource settings. Stool-based PCR methods have dramatically improved our ability to measure enteric infections, but the challenge of collecting stool and need for near-continu…