Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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Mark Joseph Mulligan · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $1,341,481 — PROJECT SUMMARY This supplement proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) research to be carried out at the NYU VTEU. We will participate in the implementation of in DMID protocol 21- 0012, “A Phase 1/2 Study of Delayed Heterologous SARS-CoV-2 Vaccine Dosing…
DANI DUMITRIU · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $881,466 — ABSTRACT The COVID-19 pandemic has highlighted and exacerbated health disparities related to structural racism and discrimination (SRD), economic marginalization, and other social determinants of health (SDOH). Pregnant and postpartum women face unique social and health vulnerabilities related to th…
Farhang Alem · GEORGE MASON UNIVERSITY · 2021 · $3,330,000 — Project Summary/Abstract In 2002, the NIAID convened a Panel on Bioterrorism and its implications for Biomedical Research to determine key priorities and short- and long-term goals for biodefense research in the United States. In response to the panel’s recommendations, the NIAID provided funding fo…
JUDITH FEINBERG · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $154,576 — Project Summary/Abstract The COVID-19 pandemic caused by SARS-CoV-2 has resulted in social distancing measures, the total consequences of which, particularly as they relate to substance use and drug overdose deaths, are unknown. News reports and early studies have suggested increases in opioid overd…
Michael Cohen-Wolkowiez · DUKE UNIVERSITY · 2021 · $36,243,390 — ABSTRACT There is an urgent need to reduce disparities in COVID-19 associated morbidity and mortality outcomes in historically marginalized and vulnerable populations disproportionately affected by the COVID-19 pandemic. To address this need the Rapid Acceleration of Diagnostics for Underserved Popu…
Reed Johnson · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $1,296,332 — Viruses of the Coronaviridae family are enveloped viruses that possess a large (30kb), single-stranded, positive sense, RNA genome that infect a large number of mammals (alpha and beta coronaviruses) and birds (gamma coronaviruses). Four different seasonal coronaviruses (two alpha coronaviruses, 229…
Andrea Lisco · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $22,511 — The extraordinarily wide spectrum of clinical manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, ranging from completely asymptomatic to fatal disease, represent an unexpected and unexplained clinical feature for an emerging highly contagious novel…
Daniel Menendez Rendon · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $9,190 — p53 is central to human DNA repair, damage checkpoints and many aspects of human biology. Most cancers are altered for p53 function. IDENTIFYING p53 TARGETS. Identifying the universe of p53 direct transcriptional targets is clinically relevant, especially since many of these may have therapeutic val…
Samuel Michael · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $10,999,069 — Research Services Core (RSC)staff provide support to the NCATS activities in high-throughput screening, assay development, and optimization as well as follow-up and dose-response library-plating services for NCATS screening activities. The Compound Management team works in conjunction with the Autom…
Manas Ray · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $1,338,679 — The NIEHS knock out mouse core (KOMC) is a service orientated facility, which aims at helping investigators at the NIEHS to develop animal models to further their research and fulfilling the mission statement of NIEHS. The KOMC aids investigators in generating transgenic mouse models specific for th…
Jason Williams · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $670,590 — A variety of service and collaborative projects in protein identification have been or are being carried out within the Mass Spectrometry Research and Support Group with approximately 3000 samples analyzed from 42 scientists representing 20 principal investigators or core heads from 6 laboratory bra…
Trevor Keith Archer · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $2,212,139 — The Epigenomics and DNA Sequencing Core Lab provides a variety of services to the NIEHS scientific community. For next-generation sequencing, the core produces hundreds of millions of short sequence reads of individual DNA molecules using the Illumina NovaSeq 6000, NextSeq 500 or Illumina's MiSeq pl…
Philip Murphy · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $41,999 — We have written an Animal Study Proposal that has been approved by the NIAID Animal Care and Use Committee and the SVC. We began research in fall, 2020 after the BSL3 and ABSL3 facilities opened for this purpose. To date, WT and huACE2 transgenic mice on a C57BL/6 background have been infected with…
Robert Best · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2021 · $907,743 — The project has addressed the following areas in the past year: 1. Continued studies of SARS-Cov2 Main Protease. In collaboration with John Louis (NIDDK), we have investigated the autoprocessing mechanism of the SARS-Cov2 Main Protease. A reaction coordinate was developed that can describe the conf…
Xin Wei Wang · DIVISION OF BASIC SCIENCES - NCI · 2021 · $238,096 — In collaboration with Luigi Notarangelo, MD, Irini Sereti, MD and Andrea Lisco, MD, PhD of NIAID, we are working to determine the landscape of viral exposure signature as the humoral immunological responses to the history of viral infection in COVID-19-positive patients using the VirScan platform. W…
Michael B Fessler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $79,472 — New accomplishments to date: 1) Avanti Lipids synthesized enantiomeric 25-hydroxycholesterol (25HC), which will be used as a control for 25HC to help distinguish protein-targeted vs. non-protein-targeted (membrane) effects of this oxysterol in our studies. 2) We have completed several in vivo infe…
Karran Phillips · NATIONAL INSTITUTE ON DRUG ABUSE · 2021 · $7,812,605 — In 2020 the Office of the Clinical Director (OCD), Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), NIH provides clinical research support to three clinical research branches, the Clinical Pharmacology and Therapeutics Research Branch (CPTRB), the Translational Addiction M…
KAREN M RIDGE · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $539,501 — PROJECT SUMMARY PROJECT 1 Severe viral pneumonia, due to influenza A virus (IAV) damages the lower respiratory tract to cause acute respiratory distress syndrome (ARDS). The persistence of respiratory failure in patients with ARDS is a consequence of persistent inflammation and the failure of normal…
AL OZONOFF · BOSTON CHILDREN'S HOSPITAL · 2021 · $2,129,888 — IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC) Project summary In December 2019, a cluster of respiratory illness in Wuhan, China defined the onset of a global pandemic involving a novel coronavirus (SARS-CoV-2) with associated respiratory di…
TIMOTHY STEDMAN · AMERICAN TYPE CULTURE COLLECTION · 2021 · $3,008,705 — This contract provides unique and quality-assured infectious reagents and resources to the scientific community for use in basic research and product development. The scope of this contract includes the acquisition, authentication, production, preservation, storage, and distribution of research and …