Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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RANDI HORNBACK · BATTELLE CENTERS/PUB HLTH RES & EVALUATN · 2021 · $426,458 — The Evaluation and Testing Services (ETS) for Vaccines and Other Biologics for Infectious Diseases contract provides a variety of product development services from early feasibility studies through manufacture of Phase I/II material, including assay development; immunogenicity and efficacy testing; …
DEBORAH PHIPPARD · PRECISION BIOSERVICES, INC. · 2021 · $117,253 — This contract provides critically needed comprehensive services related to operation of the NIAID Specimen Repository (NSR), and it will continue to help (1) secure, receive, catalog, process, aliquot, store, and disburse human biological specimens from subjects participating in NIAID-sponsored coho…
RICHARD G WUNDERINK · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $263,749 — PROJECT SUMMARY CORE B Lower respiratory tract infections cause nearly 80% of deaths from infectious diseases in the US, and respiratory viruses, such as influenza and SARS-CoV-2, are increasingly recognized as common causes of severe community-acquired pneumonia (CAP). As mortality from severe CAP …
Heidi M. Crane · UNIVERSITY OF WASHINGTON · 2021 · $159,270 — This supplement is appropriate for PA-18-591 and responsive to research areas requested in the NIDA supported NOSI on the 2019 Coronavirus (NOT-DA-20-047) including research to determine whether drug use is a risk factor for the onset/progression of COVID-19 (the disease caused by SARS-CoV-2), resea…
Amir Kol · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $235,500 — This R21 proposes to fill a major scientific gap by investigating a new therapeutic approach for multisystem inflammatory syndrome in children (MIS-C) using an innovative and clinically relevant feline model. We propose to test a novel multi-pronged therapeutic paradigm targeting viral replication, …
OFER LEVY · BOSTON CHILDREN'S HOSPITAL · 2021 · $2,129,888 — IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC) Project summary In December 2019, a cluster of respiratory illness in Wuhan, China defined the onset of a global pandemic involving a novel coronavirus (SARS-CoV-2) with associated respiratory di…
Nitin S Baliga · INSTITUTE FOR SYSTEMS BIOLOGY · 2021 · $76,331 — Project Summary The NIAID national protocol intends to enroll at least 1000 COVID19 patients in a study designed to track infected patients through tracking, over time, their immune responses, viral load, and a variety of multi-omic analytes that can provide deep insights into how infection by SARS-…
ARUN K GHOSH · PURDUE UNIVERSITY · 2021 · $750,974 — Abstract The main objective of this project is to advance our extensive preliminary results and develop novel protease inhibitor drugs for the effective treatment of COVID-19. The COVID-19 pandemic, caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), eme…
Jonathan B Overdevest · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $178,610 — PROJECT SUMMARY Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus. The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed during the COVID-19 pandemic highlight a knowledge gap, where risk fac…
Janelle Rios · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2021 · $249,873 — Project Summary/Abstract El Paso is a Texas-Mexico border city with a predominantly Hispanic (82%) population (US Census Bureau, 2020) and multiple risk factors for poor health outcomes. In comparison with other areas of the country, El Paso County has experienced a disproportionate increase in the…
Michael Cohen-Wolkowiez · DUKE UNIVERSITY · 2021 · $7,653,833 — Over 4 million people have been infected with the SARS-CoV-2 virus and more than 460,000 have died. Novel mitigation strategies and community level public health interventions are critical to stop the spread of this virus. The goal of frequent home testing is to identify SARS-CoV-2 index cases early…
Alan Tackett · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2021 · $770,000 — PROJECT SUMMARY The continuing emergence and subsequent circulation of SARS-CoV-2 variants across the world is of concern for the global effort of controlling the Coronavirus Disease (COVID)-19 pandemic. Despite a high-burden of disease overall, Arkansas has been slow to sequence viruses associated …
JODI K CRAIGO · CYTOAGENTS, INC. · 2021 · $1,000,000 — Abstract CytoAgents is developing GP1681 (beraprost-314d) to regulate the uncontrolled inflammatory response that can result from viral infections. This inflammatory response is associated with increased disease severity, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and death…
Steven Gary Van Lanen · UNIVERSITY OF KENTUCKY · 2021 · $417,474 — SARS-CoV-2 is a positive-sense, single-stranded RNA [(+)ssRNA] virus that relies on its RNA-dependent RNA polymerase (RdRp) for survival. Within the months of April and May, five groups have independently reported the production of recombinant SAR-CoV-2 RdRp and a preliminary activity assessment of …
Hayden C Metsky · BROAD INSTITUTE, INC. · 2021 · $129,165 — Project Summary/Abstract Viral genome sequencing is growing exponentially and cutting-edge molecular technologies, guided by genomic data, show great promise in detecting and responding to viruses. Yet we lack a computational framework that efficiently leverages viral data to design the nucleic or a…
SAMUEL JEREMY PLEASURE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $323,000 — PROJECT ABSTRACT COVID-19 is associated with a growing number of peripheral and central nervous system complications. It has become clear that a subset of these syndromes, including acute necrotizing encephalopathy, steroid- responsive encephalitis and Guillain-Barré syndrome, are likely due autoim…
William Paul Duprex · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $3,330,000 — Overview The University of Pittsburgh has been ranked among the top ten recipients of NIH funding since 1998. Currently it is ranked fifth nationally in the number of awards received, totaling $570 million in FY2020. The Schools of Medicine and Public Health obtained a significant proportion of th…
DEAN R MADDEN · DARTMOUTH COLLEGE · 2021 · $2,460,000 — The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards lo…
Benjamin Hyun Han · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $107,487 — Project Summary/Abstract: This application is being submitted in response to NOT-DA-21-044: Administrative Supplements to Support Research on Health Equity in NIDA-funded Grant Awards. The parent K23 award seeks to improve the delivery of coordinated chronic disease management for older adults with …
Eric Banks · BROAD INSTITUTE, INC. · 2021 · $78,000 — Abstract/Summary Viruses play a role in 10 to 20% of human cancers. Tying specific viruses to human cancers remains a fundamental biomedical and technological problem. One virus family, the human papillomaviruses (HPVs), comprises over 225 known types and causes lesions ranging from benign warts to …