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9873 documents

Development of a Targeted Nitric Oxide-Related Drug to treat SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

STUART A LIPTON · SCRIPPS RESEARCH INSTITUTE, THE · 2020 · $177,500 — COVID-19-Related Administrative Supplement to DP1 DA041722 under PA-18-591 and NOT-DA-20-047 PROJECT SUMMARY The worldwide pandemic of the 2019 novel coronavirus, or COVID-19, has led the research community to believe the possibility that it could affect some populations with substance use disorders…

Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Josephine F. Esquivel-Upshaw · UNIVERSITY OF FLORIDA · 2020 · $219,405 — This R01 competing revision is focused on establishing the sensitivity of our novel sensor to the SARS-CoV2 protein antigen. This is a revision of our current aims in response to the NIH NIDCR NOSI for immediate and high impact research to help protect dental professionals in this COVID-19 pandemic.…

Qungasvik (Toolbox): Prevention of Alcohol/Suicide Risk in Alaska Native Youth

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

JAMES R. ALLEN · UNIVERSITY OF ALASKA FAIRBANKS · 2020 · $235,846 — The proposal is in response to NOT-OD-20-087 Guidance for NIH-funded Clinical Trials and Human Subjects Studies Affected by COVID-19, and applied for using PA-18-591 Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional), through pare…

Evaluation of Smoke-Free Housing Policy Impacts on Tobacco Smoke Exposure and Health Outcomes

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Donna R Shelley · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $774,729 — ABSTRACT. By mid-June, 2020, COVID-19 associated hospitalization rates among Hispanic/Latino and African-American/Black persons in the United States were 4 and 5 times greater than that of non-Hispanic White persons. New York City (NYC) became the epicenter of COVID-19 early in the epidemic and dist…

High Accuracy Nanopore Sequencing

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

JENS GUNDLACH · UNIVERSITY OF WASHINGTON · 2020 · $313,632 — This project is an expansion of the scope of our current funding which was awarded to improve nanopore sequencing. In the course of our research to improve nanopore DNA sequencing, we have discovered and developed a new high-resolution single-molecule tool to observe the motion of helicases and poly…

Center for Collaborative Research in Minority Health and Health Disparities

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Emma Fernandez-Repollet · UNIVERSITY OF PUERTO RICO MED SCIENCES · 2020 · $187,497 — Project Summary/Abstract: Among patients with COVID19, there is a high prevalence of cardiovascular disease, and >7% of patients experience myocardial injury as a result of the infection (22% of critically ill patients). COVID19 may disproportionately affect people with cardiovascular disease. Previ…

Colorado REACH Hub

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

RICHARD C DUKE · UNIVERSITY OF COLORADO DENVER · 2020 · $1,166,125 — Project Summary This application is being submitted by the Colorado AMC Research Evaluation and Commercialization Hub (REACH) in response to NOT-EB-20-008, Availability of Administrative Supplements on Biomedical Technologies for Coronavirus Disease 2019 (COVID-19). The COVID-19 pandemic has had unp…

COVID-19 testing and prevention in correctional settings

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Lauren Brinkley-Rubinstein · YALE UNIVERSITY · 2020 · $3,829,777 — PROJECT SUMMARY Correctional settings account for 39 of the 50 largest outbreaks of COVID-19 in the US to date. Transmission of the COVID-19 virus (SARS-CoV-2) is amplified in correctional settings due to restricted access to sanitizing supplies, personal protective equipment and diagnostic tests, c…

New Jersey Alliance for Clinical and Translational Science: NJ ACTS

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Reynold Alexander Panettieri · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · 2020 · $3,792,941 — SUMMARY The COVID-19 pandemic disproportionately impacts members of under-represented minority (URM) communi- ties. Unfortunately, URM and other vulnerable communities remain profoundly under-tested. As such, new ap- proaches are needed to disseminate and accomplish testing that could be generalized…

ST6Gal-1 Sialyltransferase in Inflammation

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Joseph TY Lau · ROSWELL PARK CANCER INSTITUTE CORP · 2020 · $183,648 — Project Summary (Supplement) COVID-19 is a pandemic in which the high mortality rate is driven by high infectivity and rampant transmission of the causative corona virus, SARS-CoV-2. The unpredictable and very rapid life-threatening deterioration in some but not all viral-positive patients remains u…

Harvard/Boston/Providence Clinical Trials Unit (Harvard/B/P CTU)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Raphael Dolin · BETH ISRAEL DEACONESS MEDICAL CENTER · 2020 · $900,000 — Harvard/Boston/Providence Clinical Trials Unit (H/B/P CTU) Administrative Supplement (06/01/20-11/30/20) PROJECT SUMMARY The Harvard/Boston/Providence Clinical Trials Unit (CTU) conducts clinical trials to address research areas of three NIAID HIV Clinical Research Networks: vaccines against HIV inf…

A single antiviral to treat multiple opportunistic infections

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Stacy Remiszewski · EVRYS BIO, LLC · 2020 · $901,086 — In response to the Notice of Special Interest regarding the Availability of Emergency Competitive Revisions for research on SARS-CoV-2 and COVID-19 (NOT-AI-20-034), the proposal herein is focused on the development of SARS-CoV-2 therapeutic candidates with broad-spectrum activity against multiple co…

Florida Development in Early Childhood: Adversity and Drug Exposure (FL-DECADE) Study

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Kelly K. Gurka · UNIVERSITY OF FLORIDA · 2020 · $189,329 — PROJECT SUMMARY In this administrative supplement application, we propose to expand the original aims of our Florida Development in Early Childhood: Adversity and Drug Exposure (FL-DECADE) Study (R34DA050299) to accomplish NIDA research objectives related to the 2019 Novel Coronavirus (2019-nCoV, al…

Preventing Alcohol Misuse among Young Adult Veterans through Brief Online Intervention

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Eric R. Pedersen · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $165,000 — Project Summary/Abstract This application is being submitted in response to NOT-OID-20-097, Availability of Administrative Supplements and Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus and the Behavioral and Social Sciences. We are requesting an administrative supplement (…

Hazardous Materials Worker Health and Safety Training

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Mitchel A Rosen · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $300,000 — The New Jersey / New York Hazardous Materials Worker Training Center will provide training for essential works to respond and work safely when faced with exposure to COVID-19. The Center will provide train-the-trainer course via distance web conferencing to expand the knowledge of trainers to provid…

Clinical Studies Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

BRYAN O BUCHHOLZ · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $81,242,031 — RESEARCH SUMMARY/ABSTRACT The goal of this initiative is to fast-track the implementation of carefully selected CAPCaT-supported projects that can help address the urgent healthcare issues created by the COVID-19 pandemic. The extent and urgency of the situation requires an aggressive approach to ac…

Epidemiology of SARS-CoV-2 in Low-income Countries.

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Michael S Glickman · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $632,901 — The COVID-19 pandemic has now spread from high- and middle-income countries to low-income countries, including Haiti and Tanzania. The natural history of COVID-19 is unknown in low-income countries. We propose to study a combined cohort of 3,054 adults in Haiti and Tanzania to determine the attack r…

Synergistic integration of topology and machine learning for the predictions of protein-ligand binding affinities and mutation impacts

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Guowei Wei · MICHIGAN STATE UNIVERSITY · 2020 · $116,389 — Project Summary The success of the ongoing battle with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) depends crucially on the availability of effective diagnostics, vaccines, antibody therapeutics, and small-molecular drugs. Although SARS-…

Statistical Methods and Algorithms for Population Genomic Inference

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Bruce RANNALA · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $206,764 — Project Summary/Abstract The proposed supplement is in response to the “Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (2019-nCoV).” In particular, it is in response to the stated NIGMS Interests: “Incorporation…

Mapping Immune Responses to CMV in Renal Transplant Recipients - Mechanistic Assays Core (UCSF)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

ELAINE F REED · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $208,861 — ABSTRACT The COVID-19 clinical syndrome caused by the SARS-CoV-2 virus has the potential to cause significant morbidity and mortality in previously healthy patients. A significant observation is that although this infection may result in a self-limiting upper respiratory infection or mild pneumonia …