Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $3,504,680 — Novel means first to better characterize and then to treat infection with major respiratory pathogens using existing or newly developed strategies are a primary focus of this important project within the Clinical Research Section. In this regard, our Section has undertaken clinical research efforts …
Jay Chiorini · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2020 · $2,447,071 — Application of these vectors for disease with unmet clinical need are ongoing. We have previously shown that in vitro transduction with a novel AAV referred to as 44.9 has unique cell tropism and can transduce acinar cells in the parotid and sublingual glands (DiPasquale manuscript under revision).…
Thomas Quinn · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $778,661 — HIV/AIDS is a global pandemic with 38 million individuals living with HIV infection, and approximately 45 million have died from AIDS worldwide. The objectives of this project are to define the unique epidemiological, clinical, virologic, and immunologic features of HIV and its co-infections in deve…
Matthew Wheeler · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $120,583 — With the increasing complexity of large datasets, the development of novel statistical techniques that can create informative analyses, which allow scientists and decision makers, to leverage the richness of the data source is needed. This research seeks to develop methodologies that extract meanin…
Shepherd Schurman · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $1,203,002 — The Environmental Polymorphisms Registry (EPR) of over 17,000 participants provides a unique resource for a variety of studies dedicated to clarifying the interaction of genetic and environmental determinants of human health. The EPR's subject and sample resources (blood, DNA, and other materials) c…
Peter Crompton · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $2,359,843 — Malaria caused by Plasmodium falciparum remains a major public health threat. Over 225 million cases of malaria occur annually among the world's poorest populations, claiming the lives of approximately 500,000 children each year in Africa alone. The widespread implementation of malaria control inter…
Steven Holland · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $2,320,134 — The major activities of this research project in the past have centered around optimizing the methods and procedures for imaging rhesus macaques, NZW rabbits, and common marmosets on new scanners while conducting a variety of chemotherapy and basic immunology experiments in Mtb models. As a part of …
Kaitlyn Sadtler · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2020 · $379,950 — Utilization of High-Color Flow Cytometry for Interrogation of Immune Activation and Polarization in Medical Device Development and Infectious Disease We have implemented the use of high-color flow cytometry on human samples and are currently designing antibody panels for mouse samples. Most antibod…
Richard Davey · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $3,487,152 — The FLU 003 Plus (Respiratory Virus Hospitalization Study, INSIGHT Protocol No. 003) opened in September 2009 as the H1N1v Hospitalization Study (FLU 003). The initial purpose was to consecutively enroll individuals locally diagnosed with influenza A who were hospitalized with complications or sever…
Samuel Michael · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2020 · $10,097,450 — Research Services Core (RSC)staff provide support to the NCATS activities in high-throughput screening, assay development, and optimization as well as follow-up and dose-response library-plating services for NCATS screening activities. The Compound Management team works in conjunction with the Autom…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2020 · $582,613 — While antibody-based therapeutics have emerged as a major component in cancer treatment, the generation of antibodies to important targets such as cell surface receptors and ion channels remains difficult. These proteins contain buried functional sites that are unreachable by classical mouse or huma…
George Dold · NATIONAL INSTITUTE OF MENTAL HEALTH · 2020 · $1,997,677 — This past year, the Section on Instrumentaion (SI) had the unique opportunity to support the research of various Labs & Sections within NIMH, NINDS, NICHD, and NCCIH. During the past twelve months, investigators from these labs and branches requested 275 formal projects from our staff. Each of these…
Iain Fraser · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $12,723 — Cells of the innate immune system, such as dendritic cells and macrophages, constantly patrol host mucosal surfaces and peripheral tissues for signs of infection or injury. Since many people infected with SARS-CoV-2 clear the virus without developing symptoms, aspects of the innate immune response m…
Stephen Patrick Walton · MICHIGAN STATE UNIVERSITY · 2024 · $289,946 — Project Summary Intercellular communication based on the delivery of miRNAs from one cell to adjacent or remote cells is now known to be a critical part of normal cellular/organismal function. Recent work has demonstrated that a new class of extracellular nanoparticles, exomeres, may be more importa…
Marcus E. Peter · NUAGO THERAPEUTICS INC · 2024 · $400,000 — PROJECT SUMMARY Prostate cancer (PC) is the most common cancer in men, and the second leading cause of cancer death among men in the United States. There is a critical unmet need to develop novel, efficacious therapeutics for PC. NUAgo Therapeutics, Inc. is developing an RNA-interference-based thera…
Channabasavaiah Gurumurthy · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $330,025 — Many human diseases are caused by faulty genes. The best way to treat them is by gene therapy, a concept that has been around for over four decades. One of the major challenges of gene therapy is the lack of reliable technologies to deliver healthy gene copies to target cells. Some commonly used del…
Esma Alp · KALOCYTE, INC. · 2024 · $997,590 — Research Summary/Abstract ErythroMer (EM) is a novel biosynthetic blood substitute developed to address the critically unmet need for emergency transfusion in situations where the use of banked red blood cells (RBCs) are either not available or undesirable. EM is a self-assembled lipid-oligomeric hy…
Anne Elizabeth Newell-Fugate · TEXAS A&M AGRILIFE RESEARCH · 2024 · $419,056 — SUMMARY Mitochondrial dysfunction in post-menopausal women due to loss of estradiol (E2) alone or in combination with age-induced accumulation of reactive oxygen species (ROS) may play a central role in development of metabolic dysfunction-associated steatotic liver disease (MASLD). Impaired oxidati…
Luiz Miguel Quinn Camargo · UBIQUITX, INC. · 2024 · $6,500 — PROJECT SUMMARY Pharmacologically targeting intracellular proteins is a key challenge of modern drug development, requiring innovation and the development of new technologies. This challenge is made more difficult by the fact that many protein targets remain beyond the reach of established drug disc…
Sangpil Yoon · UNIVERSITY OF OKLAHOMA · 2024 · $363,919 — Project Summary / Abstract The development of site specific nucleases for precise gene engineering has advanced basic understanding of genes and their connection to phenotype-causing mutations and physiologically relevant endpoints and treatment strategies to cure human diseases and medical disorder…