Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Bryan L Copple · MICHIGAN STATE UNIVERSITY · 2024 · $483,735 — Modified Project Summary/Abstract Section The summary/abstract did not require alteration The leading cause of acute liver injury and acute liver failure in the United States is hepatotoxicity caused by overdose of the pain medication acetaminophen (APAP). Even with available treatments (i.e., N-a…
Anna Schibel · ELECTRONIC BIOSCIENCES, INC. · 2024 · $347,026 — Project Summary The ultimate goal in the field of RNA sequencing (transcriptomics and epitranscriptomics) is single-molecule, high-accuracy, de novo RNA sequencing, including the ability to sequence modified bases without the need for additional techniques/methods that add time, cost, and sample req…
Guizhi Zhu · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $381,938 — Project Summary The objectives of this MIRA application are to 1) in vivo profiling of heterogeneous Adenosine deaminase acting on RNA (ADAR) using RNA nano-reporters as a tool to understand ADAR biology and guide the design of ADAR- based therapy; 2) promoting endogenous ADAR modulation using chime…
Virender Kumar · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · 2024 · $105,638 — PROJECT SUMMARY This K01 application aims to promote the applicant's development to become a multi-disciplinarily trained and independent academic researcher. This application's collective strengths are defined in these 3 major areas: 1) Credentials: PI's application builds upon his productive trac…
Yizhou Dong · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $464,750 — Project Summary Cell-specific drug delivery represents one of the most important research areas in the field of drug delivery. Particularly, there are formidable challenges for in vivo mRNA delivery. For example, therapeutic window for current delivery systems is relatively narrow. A large number o…
Jacob Albright · UNIVERSITY OF MONTANA · 2024 · $38,800 — Abstract There are numerous examples of endogenous and exogenous particle-induced chronic inflammation. One model of chronic environmentally-induced inflammation is driven by exposure to crystalline silica particles. There are various occupational lung diseases that arise from exposure to exogenous …
Yizhou Dong · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $96,459 — Project Summary Cell-specific drug delivery represents one of the most important research areas in the field of drug delivery. Particularly, there are formidable challenges for in vivo mRNA delivery. For example, therapeutic window for current delivery systems is relatively narrow. A large number o…
TOHRU FUKAI · AUGUSTA UNIVERSITY · 2024 · $762,300 — PROJECT SUMMARY The aim of this grant is to elucidate the novel role of endothelial Cu uptake transporter CTR1 as a “mechanosensor” that promotes Cu-dependent inflammation and cuproptosis involved in atherosclerosis. Oxidative stress, inflammation, and mitochondrial (mito) dysfunction in endothelial…
Chunling Dai · POP BIOTECHNOLOGIES, INC · 2024 · $247,714 — Project Summary/Abstract Alzheimer’s disease (AD) currently affects ~6.2 million Americans, and this number is projected to increase to 14 million by 2060 unless novel treatments or interventions to prevent or delay the onset of AD are identified. Harnessing the immune system to prevent or remove Aβ…
Han-Yu Chuang · EXIMIUS DIAGNOSTICS CORP · 2024 · $661,609 — PROJECT SUMMARY Hepatocellular carcinoma (HCC) comprises 80-85% of primary liver cancers and frequently develops in patients with liver cirrhosis or chronic hepatitis B virus infection. HCC's poor prognosis is primarily due to advanced-stage diagnosis. Current clinical practice guidelines recommend …
Devanand Sarkar · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $70,363 — Summary Nonalcoholic steatohepatitis (NASH), the most common cause of chronic liver disease in the Western world and a major global health problem, leads to cirrhosis and hepatocellular carcinoma (HCC). The lack of an optimum therapy mandates better understanding of the molecular pathogenesis of NAS…
Panteleimon Rompolas · UNIVERSITY OF PENNSYLVANIA · 2024 · $732,045 — PROJECT SUMMARY Fuchs' endothelial corneal dystrophy (FECD) is a degenerative ocular disease affecting 4% of people over 40 and more that >300 million people globally. A hallmark of FECD is the accelerated loss of corneal endothelial cells (CECs), which are required for maintaining corneal transpare…
Oleh Taratula · OREGON STATE UNIVERSITY · 2024 · $438,608 — Project Summary Cachexia is a debilitating metabolic disorder that affects 50% of all cancer patients. Numerous clinical trials confirmed that the wasting of skeletal muscle mass is the hallmark of cachexia. During the course of the R37 parent grant, the research team developed the first messenger R…
Wang-Xia Wang · UNIVERSITY OF KENTUCKY · 2024 · $666,990 — Project Title: MicroRNA lipid-nanoparticle based therapy targets neuroinflammation and ApoE dysregulation in Alzheimer’s disease Abstract MicroRNAs (miRNA) are small non-coding regulatory RNA that have large impacts in health and disease. While prior studies have implicated miRNA in Alzheimer’s dise…
Venigalla B. Rao · CATHOLIC UNIVERSITY OF AMERICA · 2024 · $964,530 — This proposal aims to establish a new category of safe and affordable in vivo HIV cure “drugs” that would transform the health of substance users who are disproportionately affected by HIV-1 (HIV) disease. Substance users suffer from high rates of HIV acquisition and transmission, poor adherence to …
Georgios Theocharidis · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $152,236 — ABSTRACT The career development activities and studies delineated in this K01 application are designed to equip Dr. Theocharidis, the Principal Investigator (PI), with expertise in biomaterials and multi-omics in order to become an independent investigator. Non-healing diabetic foot ulcers (DFUs) a…
Gary Liu · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $91,260 — PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) is an urgent health problem in the U.S., afflicting ~15% of Americans and costing the healthcare system $120 billion/year. Despite the availability of glucose-normalizing drugs, diabetes remains the leading cause of renal failure. Current treatme…
Rajagopal Ramesh · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $535,400 — Expression of immune check point (ICP) molecules on tumor cells and the host immune cells, especially T-cells present in the tumor milieu, negatively impact the cancer treatment outcome resulting in inefficient tumor eradication. Data also exist showing chemo- and radio- therapy induce ICP proteins …
Christian Kastrup · VERSITI BLOOD HEALTH, INC. · 2024 · $707,172 — SUMMARY BACKGROUND: The balance between clot formation (coagulation) and degradation (fibrinolysis) is disrupted in patients with bleeding disorders or severe hemorrhage, resulting in increased bleeding. The extent to which fibrinolysis contributes to bleeding from the onset of acute bleeding in the…
Shuibing Chen · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $678,579 — Abstract. Extracellular vesicles and particles (EVPs) are a group of heterogeneous nanoparticles that are secreted into the extracellular milieu by many types of cells. EVPs have emerged as important mediators in cell-to-cell communications within organs. Recent studies have suggested that EVPs migh…