Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jill A Helms · STANFORD UNIVERSITY · 2023 · $38,268 — Summary of Parent R01 Maintaining the junc-onal epithelium (JE) is essen-al to preserve cementum, periodontal ligament (PDL), and alveolar bone. New insights into JE barrier func-ons came with our discovery of a Wntresponsive stem cell niche in the JE. In this proposal, our goal is to characterize t…
Zhaoyang Liu · UNIVERSITY OF SOUTHERN CALIFORNIA · 2023 · $249,000 — Project Summary Osteoarthritis (OA) is the most common form of degenerative joint disease affecting millions of people worldwide and lead to a tremendous financial burden. Currently there are no disease modifying therapies available for OA, due to limited understanding of the genetic factors and pat…
Michelle S Bradbury · WEILL MEDICAL COLL OF CORNELL UNIV · 2023 · $550,839 — Project Summary: Enormous strides continue to be made in the design of nanoparticles as highly specialized therapeutics for achieving superior outcomes over standard pharmacological agents, the latter often associated with significant toxicity that limits treatment efficacy. While cancer immunothera…
Sean German · ELECTRONIC BIOSCIENCES, INC. · 2023 · $349,996 — Project Summary Today, researchers and clinicians, in academia and industry, lack the tools and technologies needed to accurately characterize, differentiate, and sort extracellular vesicles (EVs); currently available technologies were simply not developed to characterize entities smaller than 200 n…
John Ramunas · REJUVENATION TECHNOLOGIES, INC. · 2023 · $626,743 — Abstract Rejuvenation Technologies Inc. (RTI) is taking the next translational step following their recent highly successful proof-of-concept rescue of multiple mouse models that mimic key pathological features of alcoholic hepatitis (AH). AH is an acute form of alcoholic liver disease in which the …
Jill A Helms · STANFORD UNIVERSITY · 2023 · $706,137 — Project abstract Maintaining the junctional epithelium (JE) is of primary importance if preservation of the cementum, periodontal ligament (PDL), and alveolar bone is to be achieved. New insights into JE barrier functions came with our discovery of a Wnt- responsive stem cell niche in the JE. In thi…
Wang-Xia Wang · UNIVERSITY OF KENTUCKY · 2023 · $654,613 — Project Title: MicroRNA lipid-nanoparticle based therapy targets neuroinflammation and ApoE dysregulation in Alzheimer’s disease Abstract MicroRNAs (miRNA) are small non-coding regulatory RNA that have large impacts in health and disease. While prior studies have implicated miRNA in Alzheimer’s dise…
Ke Cheng · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2023 · $767,086 — PROJECT SUMMARY Studies have demonstrated that adult stem cells such as mesenchymal stem cells (MSCs) repair myocardial infarction (MI) or ischemia/reperfusion (I/R) injury by indirect paracrine mechanisms rather than by differentiation and tissue replacement. In the past decade, exosomes have emer…
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $52,010 — Abstract Aberrant lipoprotein metabolism is a hallmark of obesity that affects >40% of Americans. Obesity and its com- plications, including type-2 diabetes (T2D), cardiovascular, amyloid and severe viral diseases, are the leading causes of premature death. The ultimate goal of this research is to …
Nathan Claude Gianneschi · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $319,331 — Project Summary The Polymeric Materials Synthesis and Characterizations Core will formulate, synthesize, and characterize lead candidates for the mitigation of mustards and provide support and chemical expertise to other cores and projects. The Core will be co-directed by Drs. Nathan Gianneschi (Dep…
Yu-Hua Tseng · JOSLIN DIABETES CENTER · 2023 · $548,678 — Project Summary/Abstract Obesity is growing at epidemic rates worldwide and leads to a broad spectrum of other disorders, which collectively form metabolic syndrome. Central to these pathologies is the adipose tissue. In mammals, there are two functionally distinct types of fat: white adipose tissu…
Marco Brotto · UNIVERSITY OF SOUTH FLORIDA · 2023 · $364,759 — Project Summary Diabetes is a leading cause of death in the US and worldwide with deleterious consequences to the musculoskeletal system. Regardless of glycemic control, diabetes in skeletal muscle manifests with altered metabolism leading to progressive skeletal muscle loss, functional decline, fas…
Jiujiu Yu · UNIVERSITY OF NEBRASKA LINCOLN · 2023 · $335,661 — Obesity is a chronic progressive disease that leads to the development of heart disease, stroke, and type 2 diabetes, which are among the top ten leading causes of death in the United States. The initiation and progression of obesity-related diseases is strongly associated with chronic low-grade inf…
Michelle S Bradbury · SLOAN-KETTERING INST CAN RESEARCH · 2023 · $64,250 — Project Summary: Enormous strides continue to be made in the design of nanoparticles as highly specialized therapeutics for achieving superior outcomes over standard pharmacological agents, the latter often associated with significant toxicity that limits treatment efficacy. While cancer immunothera…
Reyad A Elbarbary · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2023 · $395,785 — Abstract Impaired or delayed fracture healing is a clinical problem that affects >1.5 million people in the US annually; obesity and associated type 2 diabetes (T2D) are significant and independent risk factors in this context. Nearly 34% of the US population is obese, and the number is projected to…
Ji-Xin Cheng · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2023 · $390,792 — Program Summary While altered cell metabolism is emerging as a hallmark of cancer, there is an unmet need for new tools for quantitation of metabolites. NMR spectroscopy, mass spectrometry, FTIR, and Raman spectroscopy are widely used for molecular detection in tissue extracts or intact tissues. Ye…
SATHY VENKAT BALU-IYER · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2023 · $575,469 — Hemophilia A (HA) is a bleeding disorder caused by deficiency or dysfunction of Factor VIII (FVIII), an important blood coagulation protein. The replacement therapy using exogenous FVIII is the first line of therapy. However, a major clinical complication of this life-saving therapy is the developme…
John W. Schoggins · UT SOUTHWESTERN MEDICAL CENTER · 2023 · $468,599 — Project Summary Enteroviruses A, B, C, D are important pathogens that can cause a range of diseases including myocarditis, encephalitis, meningitis, conjunctivitis, hand, foot and mouth disease, and acute flaccid myelitis. Disease outcomes can be severe or fatal, particularly in neonates and childre…
ROBERT G BENNETT · OMAHA VA MEDICAL CENTER · 2023 — Metabolic disorders, such as obesity, are associated with adipose tissue hypoxia, inflammation and fibrosis, and impaired lipid uptake, causing ectopic lipid uptake other organs, such as the liver. Furthermore, the secreted adipokine profile changes dramatically, with impaired secretion of antifibro…
Jennifer Eileen Adair · FRED HUTCHINSON CANCER CENTER · 2023 · $907,227 — PROJECT SUMMARY / ABSTRACT The quest for an HIV cure remains incomplete, nearly half a century since the onset of the epidemic. Antiretroviral drug cocktails can suppress HIV infection, but suffer in their success owing to side effects and limitations in access and compliance. Injection of broadly n…