Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Briana Shimada · UNIVERSITY OF HAWAII AT MANOA · 2023 · $168,031 — This proposal will investigate the role of the selenium (Se)-recycling enzyme, selenocysteine lyase (Scly), in combination with high fructose and dietary Se deficiency impacts cardiac function. Se deficiency has been associated with an increased risk of cardiometabolic disorders including type 2 …
GABOR J TIGYI · UNIVERSITY OF MARYLAND BALTIMORE · 2023 · $23,254 — The US population at large, and particularly military personnel and first responders, are at risk of radiation exposure due to the explosion of a nuclear device, a nuclear reactor accident, and the threat of radiation terrorism. There is no radiation medical countermeasure (RCM) drug approved by th…
Irina A. Kirpich · UNIVERSITY OF LOUISVILLE · 2023 · $314,864 — Alcoholic liver disease (ALD) is a major and increasing health problem in the US (especially in Kentucky) and worldwide. In spite of the magnitude of this problem, there is no FDA-approved therapy for any stage of ALD. In addition, the mechanisms and regulators of the disease progression and severit…
Ji-Xin Cheng · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2022 · $385,566 — Program Summary While altered cell metabolism is emerging as a hallmark of cancer, there is an unmet need for new tools for quantitation of metabolites. NMR spectroscopy, mass spectrometry, FTIR, and Raman spectroscopy are widely used for molecular detection in tissue extracts or intact tissues. Ye…
Josiane Fofana · BOSTON UNIVERSITY MEDICAL CAMPUS · 2022 · $46,752 — PROJECT SUMMARY/ABSTRACT HIV remains a global threat despite the tremendous progress of combinatorial antiretroviral therapy (cART). Chronic inflammation and immune activation support an increased risk of non-AIDS co-morbidities in cART- treated HIV patients. This condition is attributed to various …
Brianna Leilani Bourgeois · LSU HEALTH SCIENCES CENTER · 2022 · $38,605 — Abstract The primary purpose of this Ruth L. Kirschstein NRSA F30 application is to provide the groundwork that will prepare the applicant for an academic medical career. Much of the applicant’s career development will come from work in High Priority HIV/AIDS comorbidity-related research, and she wi…
Pranoti Mandrekar · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 · $557,787 — ABSTRACT Liver immune cell activation is central to alcohol associated liver disease (ALD) and is poorly understood. The protein homeostasis network/pathways are crucial in safeguarding the cellular proteome from cellular stress. Amongst these, proteostasis mediator HSP90 is widely studied and exte…
Bruce D Levy · BRIGHAM AND WOMEN'S HOSPITAL · 2022 · $510,710 — Abstract It now widely appreciated that uncontrolled inflammation is a unifying component in many widespread diseases 1, including chronic lung diseases 2,3. Inhalational exposure to respirable particulate matter can be an important precipitant or exacerbate of lung inflammation. From our earlier r…
Evan Alexander Scott · NORTHWESTERN UNIVERSITY · 2022 · $761,409 — PROJECT SUMMARY Subunit vaccines combine immunodominant protein or peptide antigens from pathogens with select adjuvants, aiming to provide a more scalable, reproducible, low cost and rapid alternative to attenuated vaccines that contain live pathogens. Unfortunately, current subunit vaccines lack …
Shu-Hsia Chen · METHODIST HOSPITAL RESEARCH INSTITUTE · 2022 · $458,897 — The tumor vasculature is generally considered as leaky, and thus allows accumulation of big molecules and particles within a certain size range to penetrate and retain. Consequently, many cancer drugs have been packaged into simple nanoparticles or composite drug particles in order to improve accumu…
Shanthi K Srinivasan · VETERANS HEALTH ADMINISTRATION · 2022 — Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in veterans and its prevalence continues to increase, with the growing obesity epidemic. Currently more than 25% of our veterans are obese and a larger number are overweight. In this proposal, we will examine the pl…
Lucy Mary Golden · UNIVERSITY OF SOUTHERN CALIFORNIA · 2022 · $371,250 — PROJECT SUMMARY /ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, affecting at least a quarter of the world’s population, and therefore highly relevant to the NIH mission. From steatosis to fibrosis, hepatic inflammation drives disease progression…
Robert E Fleming · SAINT LOUIS UNIVERSITY · 2022 · $736,843 — ABSTRACT The overall goal of our proposal is to investigate how iron metabolism and erythropoietic activity are interrelated, and the mechanisms whereby dysregulation in one contributes to pathophysiology in the other. Roles for the two transferrin receptors in these processes is clear; however, lit…
Jayanta Debnath · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $713,896 — PROJECT SUMMARY Glial pathology is increasingly recognized as a key feature in neurodegenerative diseases. However, the exact mechanisms that promotes glial pathology remain unclear. Several studies implicate the autophagy machinery, a highly conserved lysosomal degradation pathway, in maintaining p…
Yizhou Dong · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2022 · $626,885 — Immunotherapy treatments such as checkpoint blockade and chimeric antigen receptor T cell therapy have demonstrated the power of the immune system to eradicate metastatic cancer, but the efficacy of immunotherapies in solid tumors remains confined to a minority of patients. A series of interlinked e…
Omar O Abudayyeh · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2022 · $574,001 — Project Summary Despite extraordinary advances in genome engineering, tools for precise and efficient gene correction across all cell types and desired edits remain lacking. Current programmable DNA cleavage tools, such as CRISPR-Cas9, rely on cellular DNA repair mechanisms, which are inefficient an…
Irina V Balyasnikova · UNIVERSITY OF COLORADO DENVER · 2022 · $588,673 — Project Abstract Glioblastoma (GBM) is the most devastating and aggressive brain tumor in adults, with patients surviving a median of only 14.6 months. Hidden behind the blood-brain and blood tumor-barrier (BBTB), the glioma cells migrating away from the tumor and invading surrounding brain tissue, …
VALERIE B GOUON-EVANS · BOSTON MEDICAL CENTER · 2022 · $596,381 — PROJECT SUMMARY / ABSTRACT Liver disease affects hundreds of millions of people worldwide. Liver transplantation remains the only treatment for end stage liver disease (ESLD); however, transplantation faces a major burden due to a shortage of liver donors. The liver is known for a remarkable regener…
ZHENG-RONG LU · CASE WESTERN RESERVE UNIVERSITY · 2022 · $74,657 — The goal of this project is to develop smart dual-targeted lipid ECO/siRNA self-assembly nanoparticles to target oncogenic long non-coding RNAs (lncRNAs) as a novel therapy to treat metastatic and drug-resistant triple negative breast cancer (TNBC). Metastasis and drug resistance are the main causes…
FENG C LIN · CLEVELAND CLINIC LERNER COM-CWRU · 2022 · $390,425 — Abstract Autoimmune uveitis, a common cause of blindness, has an unknown etiology and no known cure. We have been studying experimental autoimmune uveitis (EAU) induced in mice deficient in various complement components, inhibitors, or receptors following active immunization with a retinal antigen …