Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
JANARDAN P PANDEY · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $377,500 — Alzheimer’s disease (AD) is a heterogeneous and complex disorder and both genetic and environmental factors are likely to be involved in its etiology. Hundreds of putative susceptibility genes for late-onset AD have been reported, but the majority of these claims—with the exception of the e4 allele …
Congcong He · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $384,000 — Project Summary/Abstract The goal of this proposal is to demonstrate a novel non-degradative, non-cell autonomous, mechanism by which the autophagy machinery regulates metabolism. Although emerging evidence suggests that autophagy abnormality is implicated in metabolic dysfunction, the mechanism by…
Susan Denise Brown · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $696,143 — ABSTRACT Gestational diabetes mellitus (GDM) is a common complication that is routinely detected as part of standard prenatal care. After delivery, women with GDM are 7 times more likely to develop type 2 diabetes than those without GDM. National clinical guidelines thus urge completion of a 75-gram…
Xiaogang Li · MAYO CLINIC ROCHESTER · 2024 · $464,959 — Abstract Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in one of two genes, PKD1 or PKD2, whereas it cannot be fully understood in terms of the constrained genetic setting, especially, in families with the same genetic mutations but variable disease severity. Epigeneti…
Mina Kay Chung · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $2,784,815 — OVERALL COMPONENT PROJECT/SUMMARY ABSTRACT Atrial fibrillation (AF), the most common cardiac arrhythmia, afflicts the U.S. and world with increasing prevalence. AF incidence, progression to persistent AF, and AF complications, including stroke, are fed by increasing obesity and age. Current therapie…
Renee A. Heffron · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $1,814,736 — Modified Project Summary/Abstract Section The Center for AIDS Research (CFAR) at the University of Alabama at Birmingham (UAB) catalyzes new and nurtures ongoing HIV research – across domains of basic, behavioral, clinical, implementation, and community science – in partnership with the communities…
Keymanthri Moodley · STELLENBOSCH UNIVERSITY · 2024 · $376,418 — PROJECT SUMMARY The Research for Ethical Data Science in Southern Africa (REDSSA) project has the overall aims of producing new knowledge in regard to the ethical, legal and social implications (ELSI) of conducting data science research, to develop evidence-based, context specific guidance for the c…
HUANG-GE ZHANG · LOUISVILLE VA MEDICAL MEDICAL CENTER · 2024 — My research work largely explores the underlying physiologic questions regarding tiny vesicles called exosomes. These exosomes are released from many different types of cells or food-derived exosome-like nanoparticles and I am investigating in VA patients the promising role of exosomes as therapeuti…
Morgan Eilise Milton · EAST CAROLINA UNIVERSITY · 2024 · $107,120 — PROJECT SUMMARY/ABSTRACT Non-cholera Vibrio (NCV) species represent a notable and increasing threat to human health and food safety. The biofilms formed by Vibrio species are robust and highly relevant to host infection. Biofilms are tightly regulated communities of matrix-associated bacteria and a…
Shou-Jiang Gao · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $344,531 — N6-methyladenosine (m6A) is the most abundant internal modification on poly(A) RNA. Dynamic regulation of the m6A epitranscriptome is involved in diverse cellular functions. m6A mediates these functions by affecting mRNA translation, alternative splicing, nuclear export and degradation, and miRNA bi…
Manuel Rosero · FRED HUTCHINSON CANCER CENTER · 2024 · $44,503 — ABSTRACT A fundamental feature of human brain is its ability to use contextual information from past experience to modulate behavior. Failure to use context to modulate behavior has a great impact in human health. For instance, individuals with neurological and mental disorders often have difficulti…
Beth A Shen · UNIVERSITY OF WASHINGTON · 2024 · $78,892 — Abstract Decades of research have revealed that the composition of the human gut microbiome directly impacts human health, yet we still do not understand the mechanisms underlying formation and maintenance of this complex community. Counterintuitively, increasing evidence suggests that competitive i…
CHRISTINE L WILLIAMS · FLORIDA ATLANTIC UNIVERSITY · 2024 · $944,696 — Both social isolation and cognitive decline are urgent threats to public health, as they predispose persons to Alzheimer’s disease and related dementias. Air pollution and the built environment are community-based factors that have been shown to adversely affect cognitive function. Individual factor…
Thea Brennan-Krohn · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $466,211 — Project Summary/Abstract Antibiotics in the b-lactam/b-lactamase inhibitor (BLBLI) class are among the mainstays of antimicrobial treatment for gram-negative bacteria such as E. coli and Pseudomonas aeruginosa. Until recently, all b- lactamase inhibitors in these combinations were themselves b-lacta…
Sharon Rose Kleintjes · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $249,307 — Project Summary In response to PAR-18-901, we propose the Sustainable Academic Capacity Building for Excellence through Research and Training (SACERT) Program. Under the leadership of two US- and two South Africa-based highly experienced Principal Investigators, SACERT goals are to increase timely p…
Gregory Stefan Barsh · STANFORD UNIVERSITY · 2024 · $665,448 — Project Summary/Abstract Mendelian variation in pigmentation is a rich genetic resource to identify and study signaling pathways relevant to human biology, but the repertoire of mutations that affect pigmentation in mice and in humans coat color has become saturated. Advances in genome sequencing te…
Natalia Nieto · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $495,418 — Non-alcoholic steatohepatitis (NASH) is emerging as a major worldwide cause of liver disease in children and adults. Recent studies demonstrate substantial heterogeneity in the phenotype of macrophages (MFs) infiltrating the liver during NASH. Recruited MFs exist as two subsets, with distinct activa…
Ira J Goldberg · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $844,212 — ABSTRACT Diabetes markedly increases risk of development of atherosclerotic cardiovascular disease (CVD). Human and animal data also show that diabetes prevents the normal repair of damaged arteries that occurs upon circulating LDL cholesterol (LDL-C) reduction. Because of this, patients with diabet…
Jacob O Brunkard · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $320,956 — PROJECT SUMMARY TARGET OF RAPAMYCIN (TOR) is a deeply conserved protein kinase that regulates eukaryotic metabolism. TOR senses and integrates upstream signals, especially nutrient availability, to coordinate metabolism and promote growth only when conditions are favorable. TOR dysregulation causes…
Laura Cheney · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $194,400 — Project Summary/Abstract This proposal presents a 4 year research career development program focused on the study of macroautophagy (autophagy) in the context of HIV associated neurocognitive disorders (HAND) to increase the understanding of HAND pathogenesis with the goal of identifying targets for…