Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Gabriela Cristina Brailoiu · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $473,941 — SARS-CoV-2, the virus that causes COVID-10, impacts multiple organ systems including the central nervous system. Neurological symptoms are seen in about one third of COVID-19 patients and the virus has been found in brain tissue. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) located on cell…
EDWARD D CHAN · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — The clinical outcome for patients with severe COVID-19 remains poor due to the lack of highly efficacious treatment for such individuals. Finding a better remedy for them is an important niche and immediate unmet need. The aim of this pre-clinical project is to substantiate the therapeutic effect of…
Maria Antoninova NINOVA · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2024 · $388,750 — Project Summary Transposable elements (TEs) are mobile genetic elements that can propagate within the host DNA and have a significant impact on the genome organization and function. TEs are ubiquitous across the tree of life and occupy substantial fractions of animal genomes - about 20% of the D. m…
DWAYNE W GODWIN · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $429,824 — PROJECT SUMMARY Alcohol withdrawal (WD) produces a range of dangerous clinical symptoms, including intense seizures. Hyperexcitability underlying seizures is produced by an array of intrinsic membrane properties that are disrupted by ethanol (EtOH). Prior work has demonstrated that chronic EtOH expo…
Jack T. Stapleton · IOWA CITY VA MEDICAL CENTER · 2024 — We propose to characterize SARS-CoV-2 interactions with human T cells and examine how this influences adaptive and humoral immunity. SARS-CoV-2 (CoV2) is the etiologic agent of COVID-19, the third highly pathogenic coronavirus to emerge as a human pathogen since 2000. CoV-2 causes disease by dysregu…
Mohammad Mohseni Sajadi · BALTIMORE VA MEDICAL CENTER · 2024 — Background/Rationale: As the Coronavirus Disease 2019 (COVID-19) epidemic expands across the United States and the world, there are no proven therapies and little information is known regarding on immunity to this virus. At this stage of the pandemic, all prevention and treatment strategies that sho…
Lalita A. Shevde · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $173,559 — ABSTRACT During tumor progression, loss of cell:cell adhesion and detachment from the extracellular matrix induces dynamic reorganization of the cytoskeleton, formation of invadopodia by the tumor cells, and activation of epithelial-to-mesenchymal transition. This is enabled by tuning molecular prog…
Franklin Caval-Holme · BOSTON CHILDREN'S HOSPITAL · 2024 · $76,756 — PROJECT SUMMARY/ABSTRACT When faced with a visual scene, the brain encodes both image detail and the scene’s overall intensity, measured as irradiance. Encoding irradiance is critical for circadian regulation, pupil constriction, and image vision, among other important functions. A canonical feature…
Demonta Coleman · TEXAS A&M UNIVERSITY · 2024 · $39,353 — Project Summary The current cancer treatment bottleneck showcases the need for more innovative approaches in drug discovery efforts. As of recent, immune-checkpoint inhibitors (ICHs) have shown promise in cancer therapeutics, and work by manipulating immunoregulatory pathways involved in tumor detec…
Andrew Laurence Routh · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $511,834 — RNA viruses are exceptionally diverse and rapidly evolving. Their RNA-dependent RNA polymerases are prone to mutation, lack proof-reading capabilities (with the unique exception of coronaviruses) and frequently undergo recombination between both homologous and non-homologous templates. This confers …
JUAN M SAAVEDRA · GEORGETOWN UNIVERSITY · 2024 · $596,830 — SARS-CoV-2, the virus underlying the current COVID-19 pandemic, not only affects peripheral tissues, it also targets the brain causing microvascular lesions, microhemorrhages and neurological manifestations. The internalization of SARS-CoV-2 is initiated by the binding of the virus spike protein to …
Priyamvada Acharya · DUKE UNIVERSITY · 2024 · $762,305 — Effect of natural and engineered variations on structure and biophysics of SARS-CoV-2 spike COVID-19, caused by SARS-CoV-2, has devasted global health and economics. Vaccines are being deployed worldwide to gain control of the pandemic, although emergence of fast-spreading “variants of concern” (VO…
Hawa Vahed · TECHIMMUNE, LLC · 2024 · $300,000 — SUMMARY Over the last 2 years humanity has been confronting COVID-19 pandemic caused by the new Corona Virus 2 (SARS-CoV-2) infection. Major gaps: Mutations and deletions often occur in the genome of SARS-CoV-2 (predominantly in the Spike protein) resulting in more transmissible and pathogenic “vari…
Daniel Feldman · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $373,403 — Summary Inhibitory interneurons in cerebral cortex show rapid plasticity of intrinsic excitability in response to sensory experience and learning. The molecular mechanisms and functions of such plasticity, and its potential role in disease, are poorly understood. We study this in mouse somatosensory…
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2024 · $531,000 — Project Summary Membrane fusion, mediated by HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], is the first critical step for the virus to enter host cells and establish infection. A mature Env spike contains three copies each of noncovalently-associated receptor-binding…
Aleksandra Elzbieta Sikora · OREGON STATE UNIVERSITY · 2024 · $737,096 — ABSTRACT Neisseria gonorrhoeae (Ng), the gram-negative bacterium responsible for the sexually transmitted infection gonorrhea, is categorized as a high-priority pathogen for research and development efforts. In the US, over 50% of Ng isolates are resistant to at least one antimicrobial and the CDC h…
Alexander Deiters · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $356,542 — PROJECT SUMMARY The overall goal of this proposal is to develop a fundamentally new class of oligonucleotide agents – covalent aptamers – that will have a major impact on nucleic acid-based reagents and therapeutics. Covalent aptamers will be an enabling methodology behind new aptamer applications a…
Richard B Kennedy · MAYO CLINIC ROCHESTER · 2024 · $814,873 — PROJECT SUMMARY/ABSTRACT This application is a request for funding of a vaccine immunogenetics research program focused on identifying critical genetic and phenotypic determinants of COVID-19 infection and/or vaccination-induced immunity by examining associations between gene polymorphisms, HLA alle…
Ekaterina Selivanovitch · CORNELL UNIVERSITY · 2024 · $74,284 — Project Summary /Abstract Viruses present one of the most efficient mechanisms for intracellular cargo (i.e. viral genome) delivery in which interactions at the virus-host cell interface dictate the delivery pathway. For instance, enveloped viruses- those that are 'wrapped' in a lipid bilayer, deliv…
Ivan Zanoni · BOSTON CHILDREN'S HOSPITAL · 2024 · $743,329 — PROJECT SUMMARY Vaccines represent a highly effective public health measure to protect individuals from infectious diseases. Many vaccines work by inducing antigen-specific antibodies that neutralize the pathogen or its products and promote their clearance. Vaccines based on protein antigens usually…