Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Fredrick Heath Damron · WEST VIRGINIA UNIVERSITY · 2023 · $841,516 — PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and licensed: whole cell pertussis (DTP) and acellular pertussis (DTaP/Tdap). Pertussis was thought to be a disease of the past but…
MEGERDITCH KILEDJIAN · RUTGERS, THE STATE UNIV OF N.J. · 2023 · $365,086 — RNA 5′ end capping provides a layer of “epitranscriptomic” regulation, influencing numerous aspects of RNA fate, including stability, processing, localization and translatability. Furthermore, enzymes that remove RNA 5′ end caps play critical roles in modulating these processes. Recently, a previous…
Zhengjie Zhou · UNIVERSITY OF CHICAGO · 2023 · $110,623 — Project Summary/Abstract: This proposal describes a research and career development plan for Zhengjie Zhou, Ph.D., to transit from a postdoctoral fellow to an independent investigator position. This proposal will be based on Dr. Zhou’s past years of multidisciplinary research in nanomedicine and vas…
Karl Munger · TUFTS UNIVERSITY BOSTON · 2023 · $418,426 — Despite the currently available effective prophylactic vaccines, human papilloma virus infections remain the most common cause of venereal disease. Human papilloma virus-associated diseases are particularly prevalent in medically underserved segments of the population. Despite decades of research, t…
Xiangfei Han · BRIGHAM AND WOMEN'S HOSPITAL · 2023 · $69,500 — ABSTRACT Protein replacement therapy has been a cornerstone in treating genetic diseases (e.g., hemophilia) with loss or reduction of the function of a particular protein, by using recombinant proteins or recombinant engineered proteins. However, most protein therapeutics have short circulation live…
BALI PULENDRAN · STANFORD UNIVERSITY · 2023 · $223,238 — ABSTRACT – Overall Component In the current proposal we will use a systems vaccinology approach to address two fundamental issues in vaccinology. The first issue concerns the immunology of COVID-19 vaccines, which utilize novel platforms (mRNA) or adjuvants (Matrix M used in the Novavax vaccine). Th…
Paul Stephen Keim · NORTHERN ARIZONA UNIVERSITY · 2023 · $1,390,215 — OVERALL Section Title: Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis. SUMMARY Coccidioidomycosis, also known as Valley Fever (VF), is an important fungal disease caused by two different Coccidioides species that results in regional…
Pia S Pannaraj · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $789,998 — PROJECT SUMMARY COVID-19 cases and hospitalizations in children have increased dramatically worldwide. Although most COVID- 19 is mild in children, severe illness and post-infectious complications can occur. We and others have found that children are an important source of household and community tr…
RAVI THADHANI · EMORY UNIVERSITY · 2023 · $169,851 — Abstract The overall goal of this supplement is to develop vaccine strategies that induce strong neutralizing antibody response against HIV using mRNA and modified vaccinia Ankara (MVA) vaccine delivery platforms. To address the specific goals of the supplement, we will utilize samples obtained from…
Cecilia Maria Leal · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2023 · $167,855 — PROJECT SUMMARY We propose the acquisition of a new image-enhanced flow cytometer (Attune CytPix) to support the research of 1R01GM143723-01A1: Endosomal escape of lipid-based nanoparticles comprising Gaussian curvature lipids. RNA-based therapies offer significant potential for treating a variety o…
JOHN P MOORE · WEILL MEDICAL COLL OF CORNELL UNIV · 2023 · $500,527 — Project Summary/Abstract Many potent and effective broadly neutralizing antibodies (bNAbs) directed to the HIV-1 envelope glycoprotein (Env) trimer have been studied mechanistically and structurally. Combined, their epitopes now cover most of the external surface of Env. Passive immunization with bN…
Genevieve Giny Fouda Amou ou · WEILL MEDICAL COLL OF CORNELL UNIV · 2023 · $706,463 — Abstract As of March 2021, SARS-CoV-2 has caused more than 50 million infections and 2 million deaths, constituting an unprecedented pandemic in the modern world. While infected individuals rapidly develop IgG responses against the viral Spike after infection, some studies have indicated that indivi…
Jasdave Chahal · TIBA BIOTECH, LLC · 2023 · $966,637 — Project Abstract Avian influenza A H7N9 causes severe respiratory illness with a high mortality rate, and its zoonotic capacity has raised serious concerns over the possibility of a pandemic. The value of vaccines for pandemic-potential viruses has been demonstrated by the devastating effects of COV…
Lesia Dropulic · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $4,323,375 — Evaluation of the investigational vaccines in this project are part of the VRC mission related to biodefense and emerging pathogens. Targets include influenza, Ebola, malaria, and others. Further evaluation of vaccine approaches will continue as the VRC develops additional candidate vaccine regimens…
David Anthony Hendrix · OREGON STATE UNIVERSITY · 2023 · $305,586 — PROJECT SUMMARY: There is a need for integrative data analyses that anchor transcriptomic research in contexts predictive of human health, as illustrated by growing awareness of disease-associated synonymous transcript variants and RNA biotechnologies such as mRNA vaccines. To help uncover sequence …
Peter R Hoffmann · UNIVERSITY OF HAWAII AT MANOA · 2023 · $45,829 — Selenium (Se) is an essential micronutrient important for many aspects of human health, including optimal immune responses. The biological effects of Se are exerted mainly through its incorporation into selenoproteins as the amino acid, selenocysteine (Sec). Twenty-five selenoproteins have been iden…
Jalene Velazquez · WASHINGTON STATE UNIVERSITY · 2023 · $43,934 — PROJECT SUMMARY Survivors of Ebola virus disease (EVD) have reported a wide range of symptoms following recovery from infection. These long-term sequelae are severe enough to interfere with their daily lives and are now collectively referred to as post-Ebola syndrome (PES). Although post-viral sympt…
TERRY L. SHEPPARD · KEYSTONE SYMPOSIA · 2023 · $7,500 — ABSTRACT Support is requested for a Keystone Symposia conference entitled Vaccinology During and After COVID-19, organized by Drs. Bali Pulendran, Robert Seder and Gagandeep Kang. The conference will be held in Atlanta, Georgia from September 17-21, 2023. Since its emergence, SARS-CoV-2 has radicall…
Margaret Juliana McElrath · FRED HUTCHINSON CANCER CENTER · 2023 · $1,748,110 — FOA: PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements Activity Code/Award: UM1/A1068618 (parent award) ------------------------------------------------------------------------------------ Project Abstract This proposal outlines the scientific agenda for the COV…
JAMES B DAUNAIS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2023 · $426,250 — This project will determine the temporal and anatomic profile of COVID-19 related changes in brain function and neurobiology and whether identified changes relate to brain alterations seen in Alzheimer’s Disease (AD). Although COVID-19 is a novel coronavirus disease, studies have reported that brain…