NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Rachel Adria Katzenellenbogen · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $67,133 — Project Summary/Abstract: High-risk human papillomaviruses (HR HPVs) cause 5% of all cancers. There are preventive vaccines against HPV, but less than 2% of the world’s target population has received them. This leaves millions of women and men at risk for HPV-associated cervical, anogenital, and he…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Kari Ann Shirey · UNIVERSITY OF MARYLAND BALTIMORE · 2022 · $179,500 — SUMMARY Influenza is a highly contagious respiratory illness that the CDC has estimated to afflict ~47.5 million Americans with up to 62,00 deaths from October 1, 2019 to April 4, 2020. In the absence of a “universal influenza vaccine,” yearly vaccination is strongly recommended; however, the compo…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Monica Gandhi · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $201,875 — PROJECT SUMMARY/ ABSTRACT At this point in the COVID-19 pandemic, with vaccine roll-out ongoing, one of the most urgent questions facing people living with HIV (PLWH) and their providers is whether HIV modulates the immune response to and subsequent effectiveness of the SARS-CoV-2 vaccines. Unfortu…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Stanley Xu · KAISER FOUNDATION RESEARCH INSTITUTE · 2022 · $531,557 — PROJECT SUMMARY/ABSTRACT Despite the success of the unprecedented COVID-19 vaccine rollout in the U.S., vaccine hesitancy is evident, partly due to safety concerns about severe adverse events (SAEs) surrounding the novel technology of mRNA COVID-19 vaccines and reports of blood clots following recei…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Daniel F. Hoft · SAINT LOUIS UNIVERSITY · 2022 · $667,594 — -γ-producing Th1 cells have been extensively studied for development of novel vaccines and therapeutics against Mycobacterium tuberculosis (Mtb) infection. However, recent studies demonstrate that Mtb-specific Th1 cells alone do not predict protection against tuberculosis (TB). Therefore, although T…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Beatrice H Hahn · UNIVERSITY OF PENNSYLVANIA · 2022 · $802,293 — PROJECT SUMMARY Studying Natural SIV Reservoirs and Human Zoonotic Risk, we discovered in the last funding period that certain strains of SIV infecting Old World monkeys and African apes share unexpected antigenic cross- reactivity with HIV-1 in the functionally important V1V2 region of the envelope…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Veenu Aishwarya · AUM LIFETECH, INC. · 2022 · $400,000 — PROJECT SUMMARY/ABSTRACT Lung cancer accounts for >25% of cancer-related deaths in both men and women, making it the largest source of cancer-related mortality. Despite advancements in surgical intervention, radiation, chemotherapy, and immunotherapy, the 5-year survival rate for all types of lung c…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Sagar Prasad Yadavali · INFINIFLUIDICS, INC. · 2022 · $293,405 — Abstract Infini Fluidics is developing a Very Large-Scale Microfluidic Integration (VLSMI) chip for producing lipid nanoparticles (LNPs) for RNA therapeutics that can be scaled by a dynamic range of 1000x—from 100 mL/hr to 100 L/hr—thus enabling efficient and affordable use across all phases of drug…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Suresh B Boppana · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $675,412 — Project Summary/Abstract The novel coronavirus SARS-CoV-2 (SARS2) pandemic has so far infected greater than 65 million individuals and resulted in almost 850,000 deaths in the US. Although it has been suggested that adaptive immunity plays an important role in improving clinical outcomes of patients…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Guizhi Zhu · VIRGINIA COMMONWEALTH UNIVERSITY · 2022 · $175,170 — Summary Background on the need for in-house DNA/RNA synthesis. Nucleic acid (DNA/RNA) theranostics hold tremendous potential as an emerging class of theranostics in addition to conventional theranostics based on small molecules and protein biologics (e.g., antibodies). This has been evidenced by the…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Laurie Ann Rumker · HARVARD MEDICAL SCHOOL · 2022 · $32,875 — Project Summary/Abstract Tuberculosis (TB) remains the global leading cause of death from an infectious agent. Understanding why some patients present with early symptoms while others develop latent infections is critical for combating this illness. While environmental factors are known to elevate …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Alexander Arthur Green · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2022 · $100,000 — Project Summary Fast, inexpensive, and sensitive methods to detect the SARS-CoV-2 coronavirus are instrumental in containing the spread of COVID-19. Currently, nucleic acid testing of respiratory samples using RT-PCR is the primary and most commonly used method for diagnosing patients in the acute p…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
David Anthony Hendrix · OREGON STATE UNIVERSITY · 2022 · $298,215 — PROJECT SUMMARY: There is a need for integrative data analyses that anchor transcriptomic research in contexts predictive of human health, as illustrated by growing awareness of disease-associated synonymous transcript variants and RNA biotechnologies such as mRNA vaccines. To help uncover sequence …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
James D. Bryers · UNIVERSITY OF WASHINGTON · 2022 · $540,184 — While Staphylococcus aureus (SA) commonly asymptomatically colonizes the skin and nose of healthy humans, severe disease can result from infection of the blood, bone, skin, and lungs, as well as sites of catheters and prosthetic devices. With currently approved therapy, about one-third of patients d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Andrew Mehle · UNIVERSITY OF WISCONSIN-MADISON · 2022 · $685,427 — ABSTRACT Influenza virus is a serious public health threat causing high levels of morbidity and mortality. The annual disease burden from influenza places a significant strain on our healthcare infrastructure and economy. This is despite many efforts to control disease with yearly vaccination, antiv…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Richard John Martin · IOWA STATE UNIVERSITY · 2022 · $469,119 — Project Summary Filariases are a group of neglected tropical diseases produced by infection with microfilaria of Clade III parasitic nematodes that are transmitted by biting insects. One example is the lymphatic filariasis produced by Brugia malayi. Lymphatic filariasis is a debilitating and disfigu…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Leor S Weinberger · J. DAVID GLADSTONE INSTITUTES · 2022 · $189,000 — ABSTRACT Substantial evidence now indicates that HIV-infected individuals are at a significantly elevated risk for severe COVID-19 disease when infected with SARS-CoV-2. Moreover, persons who use and inject drugs (PWUD and PWID) have a high-risk of HIV infection and exposure to SARS-CoV-2 and face m…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
R. Brad Jones · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $254,250 — PROJECT SUMMARY/ABSTRACT Although modern therapies have dramatically improved the outlooks for people living with HIV they are unable to cure infection, leaving these individuals burdened by a lifelong commitment to antiretroviral (ARV) medication. For any given individual, maintaining lifelong adhe…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Akihiro Nishi · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $134,451 — PROJECT SUMMARY (ABSTRACT) Contact network epidemiology is a compelling epidemiologic framework that aims to model dynamic interactions of people over their social networks in order to track infection cascades, especially for communicable diseases. Network-based simulations in contact network epidem…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
ANITA H. CORBETT · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2022 · $6,500 — PROJECT SUMMARY The understanding that RNA degradation is critical for gene expression traces back to 1959 when Pardee, Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNA interference…