NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Frank Y. Wong · FLORIDA STATE UNIVERSITY · 2022 · $469,731 — The COVID-19 pandemic simultaneously highlights the potential for mRNA vaccines as well as the realities of vaccine hesitancy and health inequity among specific communities such as LatinX populations. LatinX populations were underrepresented in mRNA vaccine trials for COVID-19 much like they have be…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Gabriel D Victora · ROCKEFELLER UNIVERSITY · 2022 · $785,027 — PROJECT SUMMARY Generation of high affinity antibodies in germinal centers (GCs) is a critical step in a wide variety of clinically relevant processes, from protection against pathogens by prior infection or vaccination to the development of allergies and autoimmune diseases. Antibody affinity matur…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Pia S Pannaraj · CHILDREN'S HOSPITAL OF LOS ANGELES · 2022 · $800,605 — PROJECT SUMMARY COVID-19 cases and hospitalizations in children have increased dramatically worldwide. Although most COVID- 19 is mild in children, severe illness and post-infectious complications can occur. We and others have found that children are an important source of household and community tr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Xiaojing J Gao · STANFORD UNIVERSITY · 2022 · $194,125 — Abstract There is a critical need for RNA sensors in living mammalian cells. With the advent of single-cell RNA sequencing, the transcriptome of any cell type is readily obtainable if not already available. In contrast, we are still in urgent need for a universal method to act on such transcriptomi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Peter B. Gilbert · FRED HUTCHINSON CANCER CENTER · 2022 · $453,649 — Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for implementation of the COVID-19 vaccine trial entitled “A randomized controlled study to assess SARS-CoV-2 infection, viral shedding, and subsequen…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Charles M Rice · ROCKEFELLER UNIVERSITY · 2022 · $881,526 — Project Summary The yellow fever 17D live-attenuated vaccine has been administered to millions of people and is a highly successful and safe vaccine providing essentially life-long protection. However, the mechanisms of attenuation are poorly understood, and rare individuals suffer from sometimes f…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Ronald Goldstein · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $208,619 — Abstract As highlighted in PA-19-237, there is a gap in knowledge about non-coding RNAs and their functions for many pathogens, and the human herpesvirus Varicella Zoster Virus (VZV) is one such pathogen. VZV is one of only two of nine human herpesviruses in which microRNAs have not been reported. …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Scheherazade Sadegh-Nasseri · JOHNS HOPKINS UNIVERSITY · 2022 · $543,021 — Unconventional sources of peptides for antigen presentation Project Abstract The long term goals of this project are to understand how the antigen processing pathway generates peptide/MHC class I complexes (pMHC I) by cryptic translation. Numerous studies, from different laboratories, have shown th…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Laura Lynn Newcomb · CALIFORNIA STATE UNIV SAN BERNARDINO · 2022 · $110,250 — Influenza virus remains an unmet health issue. Although the virus is controlled with annual vaccines, these exhibit variable efficacy, and slow vaccine production means vaccines are not available during an emerging pandemic. Antivirals can stunt an influenza pandemic, but antivirals become ineffecti…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Parisa Yousefpour · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2022 · $69,802 — PROJECT SUMMARY Infectious diseases such as HIV, malaria, tuberculosis, and seasonal influenza epidemics and emergence of new pandemics remain major global health problems highlighting the need for innovative approaches in vaccine design. The precise kinetics of antigen exposure relative to inflamma…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Lbachir BenMohamed · UNIVERSITY OF CALIFORNIA-IRVINE · 2022 · $409,999 — SUMMARY/ABSTRACT Herpes simplex type virus-1 (HSV-1) infects over 3.72 billion people worldwide, including 200 million individuals in the United States. Following primary infection of the cornea, HSV-1 establishes latency in sensory neurons of the trigeminal ganglia (TG). Reactivation of HSV-1 from …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Larry C. Blaszczak · TEICHOS LABORATORIES, LLC · 2022 · $259,613 — Hemophilia A is one of the most common X-linked recessive disorders, affecting one in 5,000 male births globally. Intravenous FVIII replacement is the standard of care therapy and resistance develops to FVIII in 20– 30% of patients with severe disease from the production of anti-FVIII antibodies (in…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Justin Richner · UNIVERSITY OF ILLINOIS AT CHICAGO · 2022 · $583,700 — Nearly 400 million people are infected with dengue virus (DENV) each year through the bite of infected mosquitos concentrated in the tropical and subtropical regions of the world. Symptoms can range from febrile illness to severe dengue that manifests as plasma leakage, sudden loss of blood pressure…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
MING LUO · GEORGIA STATE UNIVERSITY · 2022 · $560,443 — The devastating impact on public health, global economy and social stability incurred by the COVID-19 pandemic in the last two years has highlighted the importance of basic research into zoonotic pathogens. This application describes structural and functional studies into the rodent-borne human path…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Wyatt ALLEN MILLER · IOWA STATE UNIVERSITY · 2022 · $216,354 — Flaviviruses include many serious pathogens such as Zika, dengue, West Nile, and yellow fever viruses. In infected cells these viruses produce abundant, noncoding, short flavivirus RNAs (sfRNAs) that comprise most of the ~500 nucleotide 3’ untranslated region of the viral genome. These novel viral R…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Peter R Hoffmann · UNIVERSITY OF HAWAII AT MANOA · 2022 · $388,500 — Selenium (Se) is an essential micronutrient important for many aspects of human health, including optimal immune responses. The biological effects of Se are exerted mainly through its incorporation into selenoproteins as the amino acid, selenocysteine (Sec). Twenty-five selenoproteins have been iden…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Michael S Diamond · WASHINGTON UNIVERSITY · 2022 · $7,990,794 — Overall Summary Given the historical outbreaks of coronaviruses, coupled with the recent emergence of SARS- CoV-2 and the destabilizing consequence of COVID-19 on global health and economy, there is an urgent and critical need to develop new vaccines capable of broad protection against existing and …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Guizhi Zhu · VIRGINIA COMMONWEALTH UNIVERSITY · 2022 · $552,247 — Small circular mRNA vaccines Abstract: Vaccines save numerous lives each year. Conventional vaccines based on pathogens, DNA, proteins, or peptides are associated with poor pharmacokinetics, limited biostability, preexisting anti-viral-vector immunity, weak immunogenicity, or safety concerns over ge…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Ai-ris Yonekura Collier · BETH ISRAEL DEACONESS MEDICAL CENTER · 2022 · $216,125 — PROJECT SUMMARY/ABSTRACT Pregnant individuals are more likely to require invasive mechanical ventilation or die from complications related to coronavirus disease 2019 (COVID-19) than non-pregnant women. COVID-19 vaccination in pregnancy can prevent the consequences of infection for the mother and pr…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2022
Yamin Li · UPSTATE MEDICAL UNIVERSITY · 2022 · $81,500 — SUMMARY The mRNA-based therapeutics has wide applications in disease prevention and treatment. However, its wide practical application is largely limited by the delivery concerns. Cationic lipids are effective carrier materials for mRNA delivery and the chemical structure of lipid molecules is criti…