Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Alan J Mouton · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $584,122 — PROJECT SUMMARY/ABSTRACT Approximately 1 million people in the United States suffer a myocardial infarction (MI) each year, leading to progressive cardiac dysfunction and development of heart failure (HF) in ~25% of surviving patients. Diabetes mellitus is a major risk factor for MI, and patients wi…
MIGUEL A VAZQUEZ · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $1,238,148 — SPRINT, and its accompanying cognitive-focused substudy SPRINT-MIND recently showed that blood pressure control (goal SBP<120 mm Hg) reduced incident mild cognitive impairment as well as a combined outcome of MCI and dementia. Divergence in opinion among experts and professional societies about BP g…
Daisy Sahoo · MEDICAL COLLEGE OF WISCONSIN · 2024 · $15,000 — ABSTRACT Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality world-wide. Development of new therapeutic approaches to combat CVD requires fundamental research and innovation, the results of which can be translated to improvement of human health. The Gordon Research Conf…
Aaron Cravens · REVEL PHARMACEUTICALS INC. · 2024 · $324,015 — PROJECT SUMMARY Diabetic kidney disease (DKD) is a major complication associated with Type 1 and Type 2 diabetes. Approximately 25% of patients with diabetes develop DKD. DKD is the leading cause of kidney failure and accounts for 44% of all end-stage renal disease cases. It is associated with heart…
GREGORY A CLINES · VETERANS HEALTH ADMINISTRATION · 2024 — Prostate cancer is the most common deadly cancer of men. Bone metastasis is a painful complication of advanced prostate cancer associated with significant morbidity. Endothelin-1 (ET-1) is a prostate cancer- secreted factor that activates the osteoblast endothelin A receptor (ETAR) causing osteoblas…
Katelyn Guastaferro · NEW YORK UNIVERSITY · 2024 · $603,181 — ABSTRACT Child sexual abuse (CSA) is a global public health problem affecting 1 in 5 girls and 1 in 12 boys before age 18. Parents are uniquely positioned to protect children from CSA, yet parents have largely been ignored in CSA primary prevention efforts and the few that do exist have not demonstr…
DAVID W SCHMIDTKE · UNIVERSITY OF TEXAS DALLAS · 2024 · $40,290 — Abstract Corneal scarring is a leading cause of blindness worldwide. Through their interactions with the extracellular matrix (ECM), stromal keratocytes play a central role in fundamental biological processes such as developmental morphogenesis and wound healing. Recent studies suggest that feedback…
Elizabeth A. Evans · TUFTS MEDICAL CENTER · 2024 · $392,637 — PROJECT SUMMARY A major driver of the U.S. HIV epidemic is inadequate access to HIV prevention and care in the criminal legal system. The End HIV Epidemic (EHE) Toolkit recommends that jails offer low-barrier access to HIV testing, treatment, and prevention to people who inject opioids, but many jus…
Mohammed R Milad · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $678,226 — Project Summary Primary characteristics of posttraumatic stress disorder (PTSD) include persistent fears and excessive maladaptive avoidance behaviors. Preclinical models of PTSD have heavily investigated the brain mechanisms of fear inhibition and active avoidance learning. Significant progress has…
JOSEPH Y LO · DUKE UNIVERSITY · 2024 · $552,589 — PROJECT SUMMARY / ABSTRACT Computed tomography (CT) imaging for the body can result in thousands of images spanning many organs and myriad possible diseases. With growing patient load as well as increasing resolution and complexity of scans, the task of CT interpretation has become daunting. To impr…
CHARNITA M. ZEIGLER-JOHNSON · RESEARCH INST OF FOX CHASE CAN CTR · 2024 · $507,193 — ABSTRACT Prostate cancer (PCa) is one of a few cancers with more than double the mortality for black men, making this one of the greatest racial disparities in cancer. Although there are documented disparities in PCa incidence and mortality related to where people live, it is unclear how residential…
Eugene Yu · ROSWELL PARK CANCER INSTITUTE CORP · 2024 · $450,011 — ABSTRACT The presence of an extra copy of human chromosome 21 (trisomy 21) is associated with Down syndrome (DS), and this is the most common live-born chromosomal alteration in humans. In the United States, DS has an incidence rate of approximately 1 in 691 newborns, and individuals with DS exhibit…
ANNE KATHRYN CHURCHLAND · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $393,750 — Abstract The main goal of my laboratory is to understand the neural circuits that support perceptual decision-making. Recent efforts to understand microcircuits within decision-making areas have been fruitful, thanks in part to the ability to identify and manipulate distinct types of inhibitory neur…
Nabila El-Bassel · COLUMBIA UNIV NEW YORK MORNINGSIDE · 2024 · $1,105,729 — Project Summary HIV prevalence in correctional facilities in the US is about five times greater than in the general population and about 14% of people living with HIV (PLWH) experience incarceration/release every year and 15% of those incarcerated do not know their HIV status. Over 50,000 people are…
Alfredo Andres Celedon · SCANOGEN, INC. · 2024 · $999,900 — Highly Multiplexed Single Molecule Tethering Summary Bloodstream infections in patients with sepsis symptoms should be promptly treated with antibiotics; however, the time required to identify pathogens using methods based on blood culture is a major obstacle to timely effective antimicrobial therap…
Kimberly Michelle Hook · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $187,940 — PROJECT SUMMARY From 2010-2020, Eastern Europe reported a 72% increase in new adult HIV infections, representing the highest rate of increase globally. Among the Eastern European countries, the HIV epidemic in Ukraine is one of the largest, with nearly 260,000 people with HIV (PWH). Nevertheless, in…
Srinivasan Dasarathy · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $275,231 — Sarcopenia, or loss of skeletal muscle mass, with impaired contractile function that causes physical frailty and decreased exercise capacity are frequent in cirrhosis and contribute to adverse clinical outcomes. Exercise training improves some measures of muscle mass and exercise capacity but the me…
Linda L Chao · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — Nearly 30 years after the end of the 1991 Persian Gulf War (GW), an estimated 25-32% of GW veterans still suffer from Gulf War illness (GWI),1 the term used to describe the symptoms that have plagued many GW veterans since their return from deployment. Although symptoms may vary from veteran to vete…
Kelly Cho · VETERANS HEALTH ADMINISTRATION · 2024 — The objective of this project is to utilize a longitudinal, VA national cardiovascular disease virtual cohort to investigate traditional, and [new] risk factors (RFs), for Heart Failure (HF), Atrial Fibrillation (AF), and stroke among United States Veterans ≥ 65. This cohort will consist of contempo…
David M Allman · UNIVERSITY OF PENNSYLVANIA · 2024 · $207,772 — Project summary There is an urgent need to develop new vaccination strategies that induce antibodies that target relevant epitopes on complex microbes. Moreover, approaches that allow control of the number and fine specificity repertoire of responding naïve or memory B cells would fuel new vaccine d…