Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
MARK LEWIS · BIOQUAL, INC. · 2023 · $157,696 — The development of effective HIV vaccines and other prevention strategies relies on the use of nonhuman primates (NHPs) in preclinical studies. To meet this need, the Simian Vaccine Evaluation Units (SVEUs) provide NHP resources that primarily support preclinical evaluation of AIDS vaccines and prev…
MORIYA TSUJI · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2023 · $1,411,690 — The goal of this contract project is to develop the glycolipid-based adjuvant for human use, with initial indications for a malaria vaccine. The scope of our product development project is to develop our novel CD1d-binding natural killer T (NKT) cell-stimulatory glycolipid, called 7DW8-5, as a versa…
Kai W Wucherpfennig · BRIGHAM AND WOMEN'S HOSPITAL · 2023 · $351,997 — Abstract T cells are central effector cells of protective anti-tumor immunity, but little is currently known about these important immune cells in human GBM. We have generated single-cell RNA-seq data on tumor-infiltrating T cell populations from GBM patients at initial diagnosis or relapse. We used…
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $28,507,101 — The NIAID Division of AIDS and the U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research (WRAIR), U.S. Army Medical Research and Development Command (MRDC) remain committed to the common objective of developing a safe and effective vaccine for HIV/AIDS. The Agencies recog…
JOSEPH M FOX · UNIVERSITY OF DELAWARE · 2023 · $944,312 — Project Summary Administrative Core This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approaches for unde…
Leonidas Stamatatos · FRED HUTCHINSON CANCER CENTER · 2023 · $163,426 — ABSTRACT ADMINISTRATION CORE The Administrative Core will support the scientific and programmatic activities of our IPCAVD Program and provide the necessary infrastructure for the Program to achieve its overall research objectives and milestones in the most efficient and effective manner. This Core …
Andrea Goldberg Edlow · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2023 · $747,949 — Project 1: Summary The COVID-19 pandemic has revolutionized our ability to decode the rules of maternal immunity. There is a significant gap in knowledge regarding innate and adaptive immune responses over the course of pregnancy and how trimester-specific perturbations in the maternal immunological…
Edward M. Schwarz · UNIVERSITY OF ROCHESTER · 2023 · $275,576 — Abstract Osteomyelitis is the bane of orthopaedic surgery, of which the majority is caused by Staphylococcus aureus. Prior to this P50 Center of Research Translation on the Osteoimmunology of Bone Infection (CoRTOBI), it was known that these rare infections following elective surgery (~1%), and our …
Florian Krammer · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2023 · $200,951 — Summary SARS-CoV-2 vaccines have been developed in record time and are now widely used in many different countries around the globe. Project 1 will focus on characterizing immune signatures associated with SARS-CoV-2 immunization using different vaccine types. In Aim 1 we will leverage existing bios…
Michael Gale · OREGON HEALTH & SCIENCE UNIVERSITY · 2023 · $1,158,449 — CORE D PROJECT SUMMARY The `Omics, Bioinformatics, and Data Management Core (Core D) serves this Program by providing high resolution functional genomics and bioinformatics computation analyses with statistical integration. The main objective of the Core is to define the gene expression signatures a…
Kristina De Paris · UNIV OF NORTH CAROLINA CHAPEL HILL · 2023 · $267,837 — ABSTRACT – B Cell Core Early development of bNAbs in infants suggest potentially distinct mechanisms in the generation of antibody breadth due to the highly dynamic nature of the infant immune system. Moreover, we have observed elicitation of bNAb precursors in infant rhesus monkeys with germline-ta…
Evan Alexander Scott · NORTHWESTERN UNIVERSITY AT CHICAGO · 2023 · $330,683 — SUMMARY-BIOMEDICAL RESOURCE CORE A major unmet challenge in kidney research is the inability of most traditional approaches and methods to harness the complexity of tissue function, structure, and cellular phenotypes. Innovations in nanotechnology provide powerful tools, reagents, and platforms that…
Barton F. Haynes · DUKE UNIVERSITY · 2023 · $936,112 — ABSTRACT - Project 3 Coronaviruses havethe potential to cause significant morbidity andmortality as demonstrated by the ongoing SARS-CoV-2 pandemic. The purpose of this program project is to develop safe and broadly-protective group 2b and 2c betacoronavirus (panbetaCoV) vaccines capable of inducin…
NATALIA ALEKSANDR OSNA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2023 · $241,763 — This project is a part of a P50 grant on exposome and alcohol. It is focused on understanding the innate immunity mechanisms, by which environmental exposure to ethanol metabolites increases the levels of hepatitis B viral (HBV) infection and promotes its persistence and liver injury. Despite a prop…
LOUISE C. SHOWE · WISTAR INSTITUTE · 2023 · $221,010 — PROJECT SUMMARY – GENOMICS SHARED RESOURCE The Genomics Shared Resource (GSR) provides state-of-the-art infrastructure and support for integrated functional genomics studies of Cancer Center (CC) investigators. The highly trained staff and their efforts to maintain costs without diminishing service,…
Marian L Kohut · IOWA STATE UNIVERSITY · 2023 · $224,877 — PROJECT SUMMARY / ABSTRACT Vaccination is an effective public health measure, yet host factors including advanced age, sex, obesity, physical or mental health status may influence vaccine efficacy. Adjuvants improve immunogenicity to vaccination but often result in greater side effects. As an alter…
Hamideh Parhiz · UNIVERSITY OF PENNSYLVANIA · 2023 · $689,181 — Project Summary For HIV cure approaches to be widely implemented, they will need to be safe, affordable and highly effective. The development strategies that allow therapeutic agents to be infused into people living with HIV (PLWH) rather than being manufactured ex vivo may represent an important st…
ANDREW HAYHURST · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2023 · $297,000 — ABSTRACT The current coronavirus (CoV) pandemic, seasonal infections by other CoV and other “cold” viruses, plus the need for annual influenza vaccinations exemplify the challenges posed by viral antigenic drift and shift. Targeting landscapes of viral structural proteins displayed on the surfaces …
John Daniel Kelly · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2023 — As SARS-CoV-2 vaccines enter mass distribution, little is known about vaccinated individuals who nonetheless develop Covid-19 (symptomatic disease or “vaccine failure”), require hospitalization, and die. Pfizer-BioNTech reported 3.8 vaccine failure cases/1,000 person-years, meaning vaccine failure w…
Jesse Hong-Sae Erasmus · HDT BIO CORPORATION · 2023 · $192,720 — Project Summary While a universal influenza vaccine, providing life-long protective immunity against all current and future drifted and shifted subtypes of influenza virus after 2 or 3 doses, would be a game-changing solution to reducing the global burden of influenza and its associated morbidity an…