Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Fanny M Elahi · JAMES J PETERS VA MEDICAL CENTER · 2024 — Dr. Elahi is an early career physician-scientist with specialty training in neurodegenerative disease and experience in biomarker development, who seeks to develop her career at the VA. By combining her clinical and molecular biology training, Dr. Elahi's long-term goal is to contribute to a better …
Jon P Boyle · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $387,539 — PROJECT SUMMARY/ABSTRACT: Toxoplasma gondii is an important opportunistic pathogen of humans where it can cause severe disease in the developing fetus and those with HIV/AIDS. Parasite development is critical for its ability to cause severe disease, yet the precise mechanisms for how it does this ar…
Dermot Patrick McGovern · CEDARS-SINAI MEDICAL CENTER · 2024 · $546,312 — Background: The inflammatory bowel diseases (IBD) are a chronic inflammatory disease of the gastrointestinal tract that are associated with a poor quality of life. There is no cure for IBD, and most people require lifelong immunosuppressive medication and also frequently need surgery. The cause of C…
Yichun Wang · UNIVERSITY OF NOTRE DAME · 2024 · $374,300 — A Convergent Bioengineered Platform for Multifunctional Therapeutic Exosomes Abstract: The overall goal of this MIRA application is to develop a convergent bioengineered platform for manufacturing and engineering therapeutic exosomes. The platform will allow the loading of drugs into exosomes with h…
Prajakta Adsul · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $151,204 — PROJECT SUMMARY/ABSTRACT As a nation, we have made tremendous advances in cancer prevention and control. However, these advances have not accrued evenly across society. New directions in population health, genetic screening and precision medicine may hold promise to promote health equity through ris…
Meredith Hay · UNIVERSITY OF ARIZONA · 2024 · $1,707,517 — PROJECT SUMMARY Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer's disease related dementias (ADRD) significantly contribute to the 55 million people world-wide who suffer with dementia. This number is estimated to increase to over 139 million people by 2050 (WHO). A …
JAKE JINKUN CHEN · TUFTS UNIVERSITY BOSTON · 2024 · $628,007 — This renewal grant application represents a deepened extension of the current grant (DE25681) focusing on the bone-enhancing effects of microRNA (miR)-335-5p, first identified and characterized in our laboratory. We have published over 9 peer-reviewed papers and won many prizes and awards in reporti…
Lawrence Camdon Long · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $172,595 — PROJECT SUMMARY / ABSTRACT This is an application for a five-year K01 award for Dr. Lawrence Long, a Research Assistant Professor at Boston University. The K01 award will support a complementary set of training activities and research aims aimed at establishing Dr. Long as an independent researcher …
Sheng Zhong · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $1,500,000 — The second phase of NIH Common Fund 4D Nucleome Network Organizational Hub Abstract The second phase of the 4DN program requires an efficient organizational center to synergize the activities of all the funded teams and integrate the research products. Accordingly, the 4DN Organizational Hub is prop…
Yulia Sapir Lekhovitser · FESARIUSTHERAPEUTICS, INC. · 2024 · $396,663 — PROJECT SUMMARY/ABSTRACT Due to the inability of the dermis to regenerate on its own, large full thickness skin loss cannot be restored naturally. The current gold standard treatment involves autologous tissue transfer in which the patient serves as their own donor, which may be challenging due to l…
Carmella Evans-Molina · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $403,201 — PROJECT SUMMARY/ABSTRACT Despite the importance of β cell failure in the progression of diabetes (type 1, type 2, and multiple monogenic forms), the underlying molecular mechanisms responsible for β cell dysfunction remain incompletely understood. Release of insulin from the pancreatic β cell occurs…
Francis Sang Yong Lee · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $526,214 — PROJECT SUMMARY Synaptic transmission and its plasticity are based on a core group of synaptic receptors that rapidly sense neurotransmitters such as glutamate and GABA. Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are typically thought to signal on slower time scales, but have a…
Joanna Giza · CITY COLLEGE OF NEW YORK · 2024 · $350,862 — Project Summary/Abstract Racial/ethnic minority (REM) researchers, who may be uniquely poised to address racial/ethnic disparities in mental and physical health, are underrepresented at all levels of the biomedical and behavioral sciences. Our Manhattan-Bridge program seeks to enhance the number of …
Cydni Nicole Williams · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $130,608 — Project Summary Sleep is critical for brain maturation and development in childhood, and for neuronal healing after injury. Traumatic brain injury (TBI) is a common pediatric critical illness affecting more than 50,000 children annually, half of whom suffer acute and chronic sleep wake disturbances …
JANI CHERI INGRAM · NORTHERN ARIZONA UNIVERSITY · 2024 · $211,163 — Project Summary/Abstract The objective of the proposed project is to increase the transfer of Native American students from accredited 2-year degree-granting institutions to baccalaureate degree programs in biomedical and behavioral sciences with the ultimate goal to aid these students in attaining …
Angela Garinis · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $627,033 — Patients treated with life-saving aminoglycoside (AG) antibiotics may experience adverse side effects of ototoxicity – permanent hearing loss and degraded speech communication. There are critical gaps in our understanding of individual susceptibility for ototoxicity, and access to effective tests th…
AHIZECHUKWU C. EKE · JOHNS HOPKINS UNIVERSITY · 2024 · $170,612 — PROJECT SUMMARY/ABSTRACT Background: Effective HIV treatment during pregnancy is critically important, both for the health of women living with HIV (WLHIV) and for prevention of perinatal HIV transmission. There are knowledge gaps though, that limit our ability to deploy new effective antiretroviral…
Jie Li · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $315,897 — PROJECT SUMMARY/ABSTRACT Natural products (NPs) have historically been a critical source of bioactive molecules, with NPs and their derivatives making up over 50% of FDA-approved small molecule drugs. In recent years, NP-based drug discovery is facing a fundamental barrier in identifying new drugs d…
Steven J Skates · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $390,494 — Project Summary This project aims to discover and validate plasma biomarkers for the early detection of ovarian cancer. A hallmark of cancer is uncontrolled cell division, leading to a doubling time of the tumor. This exponential growth stands in stark contrast to the stable or slowly changing profi…
LISA CHASAN-TABER · UNIVERSITY OF MASSACHUSETTS AMHERST · 2024 · $434,615 — Pregnancy complications are emerging as important predictors of future cardiovascular health with the demands of pregnancy acting as a “stress test” that reveals a pre-disposition to future cardiovascular disease (CVD) in the mother. Pregnancy may also reveal a predisposition to future depressive di…