Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Alexander Huang · UNIVERSITY OF PENNSYLVANIA · 2024 · $536,024 — Project Summary Anti-PD-1 therapy reinvigorates exhausted CD8 T cells, which can lead to complete tumor eradication as early as 3 weeks. Yet, despite robust T cell reinvigoration in >78% of patients, less than 40% are cured. The goal of this proposal is to understand why robust reinvigoration of exh…
Corinne E. Joshu · JOHNS HOPKINS UNIVERSITY · 2024 · $491,614 — This application is for a 5-year renewal (Years 39-43) of the Training Program in Cancer Epidemiology, Prevention, and Control (T32 CA009314) at the Johns Hopkins Bloomberg School of Public Health. Our mission is to train pre- and postdoctoral trainees to be leaders at the forefront of advancing kno…
Subo Yuan · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $400,000 — PROJECT SUMMARY Sensory neuropathy (SN) is the most common comorbidity in Human Immunodeficiency Virus-1(HIV-1) infected-patients (hHIV-SN), which affects 60% of the 37.9 million HIV infected patients in this world. hHIV-SN is particularly resistant to existing pain relief therapies and now there is…
Sriram Vaidyanathan · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2024 · $249,000 — Project Summary Cystic fibrosis (CF) is caused by mutations in a single gene called the cystic fibrosis transmembrane conductance regulator (CFTR), which codes for an ion channel that transports Cl- ions. CF affects many organs but lung failure caused by repeated respiratory infections is the leadin…
THANH H NEVILLE · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $487,315 — Project Summary Compassionate end-of-life (EOL) care is foundational to medicine, but providing patients and families in safety-net hospitals (SNHs) with the sense that they are physically and emotionally supported during a patient’s terminal hospitalization can be challenging. SNHs are public hosp…
Yaguang Xi · UNIVERSITY OF GEORGIA · 2024 · $533,414 — Project Summary: The overall survival of colorectal cancer (CRC) patients has improved significantly over the past few decades, but the 5-year survival rate for patients with stage IV CRC remains below 14%. Therefore, there is an urgent need to develop more effective and safer treatments against CRC…
STELLAH GEORGE MPAGAMA · UNIVERSITY OF VIRGINIA · 2024 · $104,082 — SUMMARY / ABSTRACT Human immunodeficiency virus (HIV) remains a major cause of morbidity and mortality in Tanzania despite access to highly active antiretroviral therapy, and tuberculosis (TB) is the leading cause of death among people with HIV in Tanzania and worldwide. The Kibong’oto Infectious Di…
Nicolaas Ida Bohnen · VETERANS HEALTH ADMINISTRATION · 2024 — The management of dopamine resistant postural instability and gait difficulty (PIGD) features, such as freezing of gait (FoG), represents perhaps the most important unmet clinical need in Parkinson's disease (PD). Research into the role of the vestibular system in the etiology of FoG has largely bee…
OLGA VINOGRADOVA · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $368,411 — Abstract Immune cells protect us from disease by detecting and responding to foreign molecules. Understanding the molecular basis of this response is critical if we are to generate new therapies for treatment or prevention of diseases involving immune cells. The objective of our research is to chara…
Brianne Olivieri-Mui · NORTHEASTERN UNIVERSITY · 2024 · $123,254 — Project Summary Antiretroviral therapy (ART) adherence among nursing home (NH) residents with HIV is less than optimal; in the literature 21% of people with HIV had no ART from their NH, which is in contrast to the 87.5% adherence among community dwelling older people with HIV. ART maintains viral s…
Jennifer E Totonchy · CHAPMAN UNIVERSITY · 2024 · $104,855 — Abstract/Project Summary Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic human herpesvirus, which causes Kaposi sarcoma (KS) as well as B cell lymphoproliferative disorders in the absence of adequate immune control. KSHV- associated tumors are a significant cause of morbidity and mortal…
Emily Wiecek · BOSTON CHILDREN'S HOSPITAL · 2024 · $142,669 — Two primary features of visual coding—spatial frequency and contrast perception—are abnormal in neurophysiological and behavioral measures of amblyopia. Mounting evidence indicates that interocular inhibition may drive amblyopic deficits, and this has led to the employment of varying gain control mo…
Ethel Cesarman · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $354,055 — The Next-Gen Oncopathology (NGO) program has the overall mission of training young diagnosticians to meet advances in our understanding of the mechanisms of cancer pathogenesis and new oncological interventional approaches thereby leading the field of pathology into the future. Specialized pathologi…
Rebecca Robbins · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $141,750 — ABSTRACT In this K01 application, I will design and conduct a pilot study of a novel behavioral intervention to improve obstructive sleep apnea (OSA) evaluation and treatment among transportation workers. I will also explore whether improved adherence to recommended OSA evaluation and treatment is m…
Ansgar J. Furst · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · 2024 — Gulf War Veterans’ Illness (GWVI) is characterized by multiple chronic symptoms including wide-spread pain and sleep disturbances. This project will focus on brainstem structures and white matter pathways that specifically link the hypothalamus, periaqueductal gray and locus coeruleus (along the hyp…
TONY G BABB · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $482,805 — PROJECT SUMMARY/ABSTRACT Seventy% of older adults (60+ yr) are overweight or obese and many are unable or unwilling to exercise due to exercise intolerance and/or dyspnea on exertion (DOE). We have identified numerous obesity- related effects that could influence exercise tolerance and DOE in obese …
KEVIN L. GARDNER · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $569,880 — Around the world, women of African ancestry and throughout the African Diaspora, continue to perish from breast cancer at significantly higher rates than any other racial/ethnic group. Although much of these disparate outcomes have been attributed to inequities in access to healthcare, socioeconomic…
MELISSA A HARRINGTON · DELAWARE STATE UNIVERSITY · 2024 · $1,142,020 — Overall Proposal Summary The Delaware Center for Neuroscience Research, established in 2012 with a COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD). Our unique Center brings together faculty and research resources from two very different in…
Kotaro Nakanishi · OHIO STATE UNIVERSITY · 2024 · $316,592 — PROJECT SUMMARY In eukaryotic cells, gene expression is regulated at multiple levels, including post-transcriptional gene silencing, where microRNAs (miRNAs) bind to complementary target RNAs and cause translational repression. Argonaute (AGO) proteins and miRNAs form RNA-induced silencing complexes…
Flemming Forsberg · THOMAS JEFFERSON UNIVERSITY · 2024 · $562,920 — Prostate cancer (PCa) is the most frequently diagnosed cancer among American males, accounting for 20% of new cancer diagnoses, but PCa is directly responsible for only 9% of cancer related deaths. PSA screening facilitates the detection of PCa, but many of the cancers detected by PSA screening are …