Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Momoko Yoshimoto · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · 2024 · $191,364 — Abstract IgA is the most abundant immunoglobulin produced in the lamina propria (LP) of the intestine and protects the host against microbial invasions into intestinal mucosa by coating and excluding them. Selective IgA deficiency is the most common immunodeficiency, and more than 50% of patients ar…
Joseph J. Fins · HARVARD MEDICAL SCHOOL · 2024 · $445,147 — Project Summary Public and private research funders have heavily invested in the application of implantable neurotechnologies to improve the management of treatment-resistant conditions and loss of function (e.g., deep brain stimulation (DBS) systems for recovery after traumatic brain injury (TBI), …
Bridget Matikainen-Ankney · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $151,492 — Project Summary/Abstract. Despite the prevalence of obesity in the United States, how obesity strengthens brain circuits that reinforce feeding is not known. This K01 proposal will identify specific neural circuits and subcircuit mechanisms that enhance feeding and are co-opted in obesity. While pri…
Shiva Abbaszadeh · UNIVERSITY OF ARIZONA · 2024 · $407,636 — SUMMARY We are proposing a new approach to a hybrid imaging modality that has been called “b+g” or “pamma-positron” Imaging [Gri07] that promises to simultaneously overcome 1) the sensitivity limits of single-gamma-ray-photon emission imaging, 2) the challenge of distinguishing between two different…
Nosheen Reza · UNIVERSITY OF PENNSYLVANIA · 2024 · $172,832 — PROJECT SUMMARY Hypertrophic cardiomyopathy is the most common inherited cardiac muscle disease with an estimated 750,000 affected individuals in the United States. However, only about 100,000 people have been diagnosed, suggesting that there are significant diagnostic and treatment gaps for individ…
Nicole Collins · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $41,362 — Project Summary/Abstract The energy utilized by the heart for contractions is primarily made by aerobic respiration. This process consists of oxidizing carbon substrates to fuel ATP synthesis. An essential substrate is oxygen which acts as the final electron acceptor. Without oxygen, ATP is rapidly …
Isabella Reichardt · UNIVERSITY OF WASHINGTON · 2024 · $43,841 — Project Summary Dilated cardiomyopathy (DCM) is a highly prevalent inherited cardiac disease, characterized by systolic dysfunction, eccentric hypertrophy, and left ventricle dilation. While pharmacologic and mechanical treatments have been shown to partially improve cardiac function, these results …
Abhijit A Date · UNIVERSITY OF ARIZONA · 2024 · $206,452 — PROJECT SUMMARY Tenofovir prodrugs, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide fumarate (TAF) are cornerstones of the first-line therapy in HIV/AIDS patients and there are at least 15 FDA-approved antiretroviral products that contain either TDF or TAF. However, due to their hydro…
Lukas Chavez · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2024 · $617,669 — The overall objective of this proposal is to investigate circular extrachromosomal DNA (ecDNA) as a potential driver of intratumoral heterogeneity and treatment resistance in medulloblastoma, the most common pediatric malignant brain tumor. Intratumoral heterogeneity is one of the leading determinan…
Dong Feng Chen · SCHEPENS EYE RESEARCH INSTITUTE · 2024 · $717,827 — Innate and Adaptive Immune Responses in the Pathogenesis of Glaucoma Glaucoma is a globally unmet medical challenge and a leading cause of irreversible blindness. Elevated intraocular pressure (IOP) is a major risk factor of glaucoma; yet, clinically it is neither required nor sufficient to cause ne…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $748,081 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
KATHERINE D MCREYNOLDS · CALIFORNIA STATE UNIVERSITY SACRAMENTO · 2022 · $106,500 — PROJECT SUMMARY/ABSTRACT The current COVID-19 pandemic has resulted in millions of infections and over 2 million deaths worldwide since SARS-CoV-2 emerged in Wuhan, China in December of 2019. This pandemic has revealed a significant treatment gap in the ability to minimize the morbidity and mortali…
MALINI RAGHAVAN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $188,280 — CD8+ T cells recognize short peptide antigens in the context of major histocompatibility complex class I (MHC- I) proteins. Three sets of genes, the human leukocyte antigens (HLA) HLA-A, HLA-B and HLA-C encode the heavy chains of human MHC-I (HLA-I) proteins, which also contain a light chain (β2-mic…
JOHN S. LAZO · KEVIRX INC. · 2022 · $55,000 — The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SAR-CoV-2, like other coronaviruses, infects human airways and enters cells via its S (Spike) protein, which binds to the human angiotensin-converting enzyme 2 (ACE2) and is primed by the…
JAMES W LARRICK · LARIX BIOSCIENCE, LLC · 2022 · $275,766 — Pan-COVID Therapeutic Abstract Severe COVID-19 remains as an urgent unmet clinical need for unvaccinated people, particularly as the SARS- CoV-2 delta and omicron variants spread globally. Despite the rapid deployment of effective vaccines, a large percentage of Americans are not fully vaccinated. A…
Wei Li · MARSHALL UNIVERSITY · 2022 · $444,000 — Project Summary/Abstract Platelet activation and aggregation is a major component of thrombosis, an underlying cause of myocardial infarction, ischemic stroke, and severe COVID-19, a new viral respiratory illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Various antipla…
Curtis Layton · PROTILLION BIOSCIENCES, INC. · 2022 · $855,260 — Abstract Monoclonal antibodies and antibody fragments are an important class of therapeutics comprising a $150B industry. However, methods for discovering and optimizing antibodies to have desired affinity are generally laborious laboratory procedures that require months of hands-on research perform…
Rebecca Powell · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $572,897 — Project Summary SARS-CoV-2, commonly termed COVID-19 for the illness it causes, has infected >4.1 million people, including >240,000 deaths. Though COVID-19 pathology in children is believed to be relatively mild compared to adults, approximately 10% of infants experience severe COVID-19 illness re…
Paul John Norman · UNIVERSITY OF COLORADO DENVER · 2022 · $714,785 — Summary To ensure a successful and sustained response to the COVID-19 crisis it becomes imperative that the functional implications of the considerable genotypic and phenotypic variation in natural human immunity are understood. Natural killer (NK) cells have major roles in controlling the innate an…
Zhenyu Zhong · UT SOUTHWESTERN MEDICAL CENTER · 2022 · $410,000 — Project Summary A balanced supply of deoxynucleoside triphosphates (dNTPs), the building blocks for DNA, is vital for the synthesis or repair of both nuclear and mitochondrial genomes, whereas its imbalance results in genome instability that precipitates cellular damage and breach of homeostasis. Re…