Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Yicheng Tu · UNIVERSITY OF SOUTH FLORIDA · 2022 · $289,348 — Project Summary We will design and develop a molecular simulation data management system, we call P2DMS, to analyze large dis- tributed molecular dynamics (MD) simulation data. The salient features of the system include: (1) a push-based local query engine design that handles data in a batch process…
Margaret Juliana McElrath · FRED HUTCHINSON CANCER RESEARCH CENTER · 2022 · $1,324,786 — FOA: PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements Activity Code/Award: UM1/A1068614-15 (parent award) ------------------------------------------------------------------------------------ Project Abstract This proposal outlines the scientific agenda for the …
Dan H. Barouch · FRED HUTCHINSON CANCER CENTER · 2022 · $3,879,990 — NOSI: NOT-AI-20-034 FOA: PA-20-135 – Emergency Competitive Revision to Existing NIH Awards Activity Code/Award: UM1/A1068614-15 (parent award) ------------------------------------------------------------------------------------ Project Abstract This proposal outlines the scientific agenda for the CO…
Dan H. Barouch · FRED HUTCHINSON CANCER CENTER · 2022 · $293,963 — Project Abstract Efforts to control the pandemic have resulted in widespread shelter-in-place orders. Transmission of SARS- CoV-2 occurs primarily through person-to-person contact and respiratory droplet transmission (Lai,2020). Household contacts of a person infected with SARS-CoV-2 are at a high r…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2022 · $2,654,146 — UNAIDS has documented millions of new HIV-1 infections every year, thus a vaccine for HIV-1 is highly desirable. To date, despite numerous efforts, no immunization regimen reproducibly elicits broadly neutralizing antibodies (bNAbs) against HIV-1. Recently available native-like HIV-1 envelope spike …
Oreola Donini · SOLIGENIX, INC. · 2022 · $829,746 — 7. Project Summary/Abstract The proposal requests funding to support manufacturing and immune characterization of a novel, emulsified adjuvant which is uniquely compatible with lyophilization strategies to enable thermostabilization of glycoprotein vaccines. The major objectives of the study are to …
Alexander Sigal · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · 2022 · $141,941 — MODIFIED PROJECT SUMMARY HIV persistence in the face of antiretroviral therapy (ART) necessitates lifelong treatment of infected individuals because of a reservoir of HIV infected cells. The Covid-19 pandemic has resulted in the critical need to better understand the interaction between HIV and SARS…
SUBHRA MOHAPATRA · JAMES A. HALEY VA MEDICAL CENTER · 2022 — COVID-19 super pandemic is still suffering from the lack of a vaccine or infection control measures and the lack of any treatments against this new virus. One of the unique features of SARS-CoV-2 is that it has an R0=2.2 (the ability of an infected patient to spread the disease) vs R0=1 for SARS-CoV…
Asrar B. Malik · UNIVERSITY OF ILLINOIS AT CHICAGO · 2022 · $739,004 — PROJECT SUMMARY / ABSTRACT Coronavirus disease 2019 (COVID-19) is a devastating systemic inflammatory syndrome caused by the coronavirus SARS-CoV-2 which has resulted in over 500,000 deaths in the US during the past year, with this high rate of mortality being attributed in large part to the develop…
Alexander Deiters · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $351,876 — PROJECT SUMMARY The overall goal of this proposal is to develop a fundamentally new class of oligonucleotide agents – covalent aptamers – that will have a major impact on nucleic acid-based reagents and therapeutics. Covalent aptamers will be an enabling methodology behind new aptamer applications a…
Brian T. Cunningham · STANFORD UNIVERSITY · 2022 · $739,473 — Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to-child HIV transmission, and a required element of routine diagnostic testing to make people aware of their HIV status. …
Gabriel D Victora · ROCKEFELLER UNIVERSITY · 2022 · $628,260 — PROJECT SUMMARY Generating an appropriate antibody response is critical for protection against reinfection and for the effectiveness of vaccination, particularly in the context of viral diseases. In addition to well-studied quantitative parameters such as antibody titer and affinity, other, more qua…
Daniel A Hammer · UNIVERSITY OF PENNSYLVANIA · 2022 · $240,984 — Summary Severe respiratory acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a world-wide pandemic causing over 525K deaths in the U.S. and over 2.6M deaths world-wide as of this writing. Here, we propose to make phospholipid vesicles and other related nanostructures (d…
JOEL N BLANKSON · JOHNS HOPKINS UNIVERSITY · 2022 · $245,625 — Project Summary Two mRNA COVID vaccines that have greater than 90% efficacy in healthy donors have been developed. However the efficacy of these vaccines in PLWH is unknown. PLWH have had suboptimal responses to some prior vaccines potentially because they make limited naïve T cell responses. We and…
Paul D. Bieniasz · ROCKEFELLER UNIVERSITY · 2022 · $6,423,268 — ABSTRACT-OVERALL The recurrent emergence of coronaviruses from animal reservoirs, and the resulting COVID19 pandemic, necessitates the development of interventions that can target diverse pandemic-threat coronaviruses. Vaccines are among the most powerful means for mitigating viral epidemics but re…
Catarina E Hioe · JAMES J PETERS VA MEDICAL CENTER · 2022 — Project Summary/Abstract The COVID-19 pandemic, which is caused by SARS-CoV-2, a novel coronavirus first detected in November-December 2019, has inflicted millions of deaths worldwide. In the US, the outbreak is affecting millions of lives. The VA hospitals, including the James J. Peters VA Medical…
YUYING LIANG · UNIVERSITY OF MINNESOTA · 2022 · $193,750 — Abstract The COVID-19 pandemic has had a profound, global impact on public health. Of the 120,000,000 cases documented world-wide, over 30 million cases have occurred in the Unites States, with >530,000 COVID deaths to date. Considerable progress in control of the pandemic has been realized in the U…
Amit Praful Khandhar · HDT BIO CORPORATION · 2022 · $1,046,474 — Project Summary/Abstract A key requirement for HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope (Env) spike. The BG505 SOSIP.664 gp140 soluble timer is engineered to display conformational epitopes recognized by several bNAbs but not …
STEPHEN COPLAN HARRISON · BOSTON CHILDREN'S HOSPITAL · 2022 · $411,968 — Summary The structure of a virus particle must conform to the mechanism by which it enters and infects a cell. We seek to relate structures of virus particles and viral surface proteins to mechanisms of the steps in cell attachment, uptake and penetration that initiate a productive infection. The pr…
Bing Chen · BOSTON CHILDREN'S HOSPITAL · 2022 · $710,320 — Project Summary Membrane fusion, mediated by HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], is the first critical step for the virus to enter host cells and establish infection. A mature Env spike contains three copies each of noncovalently-associated receptor-binding…