Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Bernard Moss · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $50,856 — We constructed a panel of recombinant MVAs that express unmodified or modified SARS-CoV-2 spike (S) protein. Intramuscular injection of mice with the rMVAs induced antibodies, which neutralized a pseudovirus in vitro and upon passive transfer protected hACE2 transgenic mice from lethal infection wit…
Matthew Hall · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $4,088,041 — During this past reporting period, NCATS continued development of a number of target-based SARS-CoV-2 assays to screen for potential hits against the virus. Optimized assays were screened against a panel of drug repurposing, clinical candidate and antiviral libraries that have been assembled at NCAT…
SANKAR ADHYA · DIVISION OF BASIC SCIENCES - NCI · 2022 · $1,079,030 — Part A. Three lines of investigations are being pursued currently. 1. Use of bacteriophages in treating human diseases because of bacterial infections. We are currently dealing with infections caused by Klebsiella. We have succeeded in defining bacteriophage cocktails that take care o…
PETER SCHUCK · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2022 · $985,108 — In the SARS-CoV-2 virion, the viral genome is scaffolded by N-protein into regular ribonucleoprotein particles (RNPs), in an as-of-yet poorly understood process. In order to elucidate the mechanism, we have previously established several steps: The starting point -- the N-protein in solution withou…
Doreen Matthies · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2022 · $1,178,067 — (1) Structure and function of magnesium channel Mrs2 Mrs2 is the eukaryotic homolog of bacterial magnesium channel CorA. CorA forms a homo-pentameric channel which forms a symmetric closed state at normal to high concentrations of magnesium with magnesium binding sites between protomers as well as n…
Anton Simeonov · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2022 · $146,225 — The antibody discovery project harnesses the therapeutic potential of small biologicals known as nanobodies. By constructing a humanized llama phage display library for use here at NCATS, it is possible to screen for therapeutically relevant nanobodies as needed. The small size of nanobodies makes t…
Niraj Tolia · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $639,365 — SARS-CoV-2 is a serious global threat that has been met with an unparalleled research response. Scientific understanding of SARS-CoV-2 is already deeper than most pathogens and it is growing rapidly. This knowledge provides an opportunity to design a vaccine that goes beyond traditional methods. …
Jonathan W Yewdell · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $297,649 — We have generated Sleeping Beauty transposase vectors that drive expression of the SARS-CoV-2 receptor ACE2 and or protease TMPRSS2 in host cells and use these vectors to create permanent transfected lines of A549, 293FT, and BHK-21 cells. We have generated a recombinant vesicular stomatitis virus t…
Jason Matthew Elinoff · CLINICAL CENTER · 2022 — IIn FY21, we determined the expression levels of known and putative host viral entry molecules including angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), neuropilin 1 (NRP1), and DC-SIGNR (CD209L/CLEC4M) in primary human lung endothelial cells (ECs). Results were co…
Yihong Ye · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2022 · $669,370 — Proteinaceous inclusions termed Lewy bodies (LBs) are a classical hallmark of Parkinson's disease (PD). The primary component of these inclusions is alpha-synuclein (a-syn), a protein with an intrinsic propensity to misfold and aggregate. In PD patients, alpha-syn inclusions first observed in the ol…
MICHAEL C SNELLER · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $214,526 — COVID-19 was identified in early 2020, and this newly recognized viral disease went on to become a worldwide pandemic. The clinical characteristics and spectrum of disease severity of acute COVID-19 were being defined, with a significant portion of those infected developing severe disease manifestat…
KELLY G TEN HAGEN · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2022 · $1,873,672 — Orchestrated restructuring events during secretory granule maturation mediate intragranular cargo segregation. Using Drosophila salivary glands, we further investigated the dynamic intracellular changes occurring in vivo as secretory cells prepare for regulated secretion. Regulated secretion is an…
Lawrence A. Tabak · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2022 · $957,584 — Our lab studies the structure and function of GalNAc-Ts. We published a methods paper in Glycoconjugate J. on mapping O-glycans using solid phase extraction (SPE) enrichment, protease digestion, and Electron-transfer/Higher Energy Collision Dissociation (EThcD) fragmentation. This work utilized O- p…
JAY A BERZOFSKY · DIVISION OF BASIC SCIENCES - NCI · 2022 · $1,200,057 — In vitro studies in macaque bronchioalveolar lavage cells: We found some effects in vitro on these cells of stimulating them with recombinant spike protein to affect expression of ACE2 and of interferons, that may play a role in infection. Little effect was seen on other cytokine or c…
ALLAN I LEVEY · EMORY UNIVERSITY · 2022 · $848,837 — The Open Drug Discovery Center for AD (Open-AD) Structural Biology core aims to provide Target Enabling Packages (TEPs): a combination of experimental tools and knowledge that will allow researchers to investigate the biology of potential drug targets and to test therapeutic hypotheses. The TEPs wil…
Ursula Buchholz · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $221,905 — We previously constructed a first-generation construct called HPIV3-EbovZ GP, in which the complete genome of the JS strain of HPIV3 was modified by the addition of the Ebov GP gene in the third gene position, between the HPIV3 P and M genes. The JS strain is thought to be an attenuated HPIV3, based…
Thomas Nutman · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $917,866 — Our work focuses on the host response to helminth infection and pathogenesis of helminthic disease; immune responses in pulmonary and extrapulmonary tuberculosis; modulation of immune responses in tuberculosis by coinfections and comorbidities such as helminth infections, undernutrition, obesity, vi…
Andrea Marzi · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $8,179,925 — Filovirus pathogenesis 1. Tai Forest virus (TAFV) causes severe disease and lethality in cynomolgus macaques TAFV is a lesser-known ebolavirus that has caused one reported human case of infection in Ivory Coast in 1994. The patient developed dengue-like symptoms including fever and rash and was evac…
KIM HASENKRUG · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $6,755 — We have completed initial studies to determine whether the depletion of the myeloid-biased hematopoietic stem cells that predominate in aged mice would result in repopulation with stem cells balanced in production of both lymphocytes and myeloid cells. Studies in depleted mice have shown rejuvenati…
Audray Harris · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $13,102 — Coronaviruses remain both a seasonal health burden and pandemic threat due to the antigenic variation of viral glycoproteins and the ability of animal coronaviruses to cause zoonotic infections in humans. Although conserved epitopes have been identified, there is a fundamental gap in understanding a…