Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Zhenyu Zhong · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $410,000 — Project Summary A balanced supply of deoxynucleoside triphosphates (dNTPs), the building blocks for DNA, is vital for the synthesis or repair of both nuclear and mitochondrial genomes, whereas its imbalance results in genome instability that precipitates cellular damage and breach of homeostasis. Re…
Arvind Murugan · UNIVERSITY OF CHICAGO · 2024 · $384,390 — Project summary/abstract The success of life on earth derives from its use of molecules to carry information and implement algorithms that control chemistry, allowing organisms to respond adaptively to their environment. The ability to transduce information and respond adaptively ultimately relies o…
MARK J SCHNITZER · STANFORD UNIVERSITY · 2024 · $789,034 — Abstract Groundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their genetic signatures. The dividends from this research will include sophisticated tools allowing selective genetic access to these cell-types, such as for imaging, optogenetic or tracing studi…
JOHN P MOORE · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $3,689,011 — Overall Abstract This HIVRAD Program Project renewal application is made in response to PAR-18-319. It contains two Research Projects, one Scientific Core and an Administrative Core, under the direction of Principal Investigator, John P. Moore, PhD (Weill Cornell Medical College; WCMC) and co-Princi…
HEINRICH GOTTLINGER · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $736,427 — PROJECT SUMMARY ADAM10 is a membrane-anchored endopeptidase that cleaves a range of membrane proteins at membrane- proximal external sites, and thus causes the shedding of their ectodomains. We now find that HIV-1 virions selectively incorporate considerable amounts of the active form of ADAM10. Our…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2021 · $22,016 — During the pandemic, Dr Ho has evaluated the challenges for developing antibody therapeutics targeting SARS-Cov-2 and wrote a review/perspective article [Ho Antibody Therapeutics 2020; PMID: 32566896]. SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angiotensin-convert…
Kyung Lee · DIVISION OF BASIC SCIENCES - NCI · 2021 · $224,347 — Our unbiased proteomic mass spectrometry and subsequent biochemical analyses showed that Plk4 binds to the C-terminal acidic domain (1401-1507) of a cellular scaffold protein, VprBP, via its C-terminal cryptic polo-box. Strikingly, HIV-1 Vpr, which binds to the WD40 domain (1003-1400) of VprBP, grea…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2021 · $638,442 — While antibody-based therapeutics have emerged as a major component in cancer treatment, the generation of antibodies to important targets such as cell surface receptors and ion channels remains difficult. These proteins contain buried functional sites that are often unreachable by classical mouse o…
Bernard R Brooks · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $349,588 — Traditional molecular modeling is performed at atomic resolution, which relies on X-ray and NMR experiments to provide structural information. When dealing with biomolecular assemblies of millions of atoms, atomic description of molecular objects becomes very computational inefficient. We develope…
NEAL DAVID EPSTEIN · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2021 · $603,253 — Endosymbionts are unicellular organisms that reside inside the cells of a host organism and can have dramatic influence over the host, ranging from nutritional provisioning to immune function and in the case of filarial nematodes, their actual development. It is estimated that more than 75% of inse…
Mark Connors · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $260,724 — Our laboratory is engaged in the study of the immune response to SARS-CoV-2 in two major areas. The first of these is the study of the immune response to natural infection. The second is the response to virus-like particles or replicating recombinant adenovirus type 4 (Ad4) vaccines. We are colla…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $476,501 — Over the past fiscal year, we have performed studies on four viral pathogens causing respiratory disease in humans, Nipah virus, influenza A virus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Sin nombre hantavirus. Work on Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2)…
Lars Pedersen · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2021 · $1,804,628 — Our lab works on a variety of different biological systems including heparan/chondroitin sulfate biosynthesis as part of our independent work, representing about 25% of our effort and in other fields including DNA replication/repair, antibody/antigen interactions and viral infection in support of ot…
SUZETTE Alise PRIOLA · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $593,205 — Transmissible spongiform encephalopathies (TSEs or prion diseases) are a group of rare neurodegenerative diseases which include scrapie in sheep, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) in mule deer and elk. In humans, the most common type of prion disease is Creut…
Matthew Hall · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2021 · $1,912,140 — During this past reporting period, NCATS began development of over a dozen novel assays to screen for potential therapeutic agents against SARS-CoV-2. Optimized assays were then screened against a panel of drug repurposing, clinical candidate and antiviral libraries that have been assembled at NCAT…
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2021 · $170,000 — The emergence of the Wuhan new coronavirus (nCoV) initiated efforts to rapidly develop effective medical countermeasures including vaccines and therapeutics against this severe disease. However, there is limited knowledge on polyclonal antibody responses generated following vaccination or nCoV infec…
ELIZABETH SHARLOW · UNIVERSITY OF VIRGINIA · 2020 · $161,500 — Project Summary We have established a human iPS-derived neuronal-glial cell model system that we are using to (1) study AβO-induced neuronal cell cycle reentry (CCR) as well as (2) screen for compounds that inhibit AβO-induced neuronal CCR. We now propose to adapt this cell-based model system to eva…
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $766,414 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
SACHIN A GUPTE · NEW YORK MEDICAL COLLEGE · 2020 · $547,406 — Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in glucose metabolism and is also a master regulator of cellular redox signaling that plays a crucial role in the regulation of vascular function. We recently isolated and characterized long (G6PD545) and short (G6PD515) G6PD isoforms in vascu…
GARY Andrew WEISMAN · UNIVERSITY OF MISSOURI-COLUMBIA · 2020 · $232,102 — Salivary gland dysfunction is symptomatic of Sjögren’s syndrome (SS), an autoimmune disease associated with lymphocytic infiltration of the salivary gland. A commonality between many human autoimmune diseases, including SS, is chronic inflammation whereby sustained accumulation of immune cells promo…