Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Gretchen Mahler · STATE UNIVERSITY OF NY,BINGHAMTON · 2021 · $303,320 — PROJECT SUMMARY Nanomaterials are increasingly used in consumer products, processed food, and food packaging, and few studies have determined the consequences of nanoparticle ingestion. The ultimate goal of this work is to determine if and how ingested metal oxide nanoparticles alter microorganism p…
Cynthia Arbeeny · MITOTHERAPEUTIX, LLC · 2021 · $253,050 — Abstract The goal of this SBIR fast-track application is to carry out a number of IND enabling studies on our siRNA drug candidate, which is designed to treat non-alcohol steatohepatitis (NASH). NASH is a form of non-alcohol fatty liver disease (NAFLD) and results from a pathological accumulation of…
Jayanth Panyam · TEMPLE UNIV OF THE COMMONWEALTH · 2021 · $374,075 — Agonists of toll like receptors (TLRs) are promising anticancer vaccine adjuvants because of their ability to induce proinflammatory cytokines necessary to generate a robust immune response. However, currently available TLR agonists suffer from a number of limitations including self-regulatory immun…
MICHAEL Allan HOLINSTAT · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $146,455 — ABSTRACT Platelets play an essential role in the vessel, maintaining hemostasis and normal blood flow following vascular insult or injury under physiological conditions. While activation of the platelet is essential for adhesion and aggregation to occur at the site of vascular injury, excessive plat…
Gabor Csanyi · AUGUSTA UNIVERSITY · 2021 · $385,000 — Project Summary Atherosclerosis, the main underlying cause of death worldwide, is characterized by chronic inflammation and accumulation of lipids in the arterial wall. Excessive lipid accumulation by macrophages (MΦs) and vascular smooth muscle cells (SMCs) plays a key role in the initiation and pr…
Craig Lewis Duvall · VANDERBILT UNIVERSITY · 2021 · $170,194 — Project Summary / Abstract Osteoarthritis (OA) is a chronic degenerative disease that affects joints and their surrounding tissues. OA can occur spontaneously with aging or be secondary to injury in the case of post-traumatic osteoarthritis (PTOA). OA/PTOA causes significant morbidity and loss of qu…
Hana Totary-Jain · UNIVERSITY OF SOUTH FLORIDA · 2021 · $535,285 — Atherosclerotic cardiovascular disease (CVD) represents a serious affliction affecting millions globally. Despite recent advances in pharmacological and percutaneous interventions, CVD remains the leading cause of death and disability in the world. One of the main therapeutic challenges facing ather…
Michelle S Bradbury · SLOAN-KETTERING INST CAN RESEARCH · 2021 · $637,054 — Project Summary: Enormous strides continue to be made in the design of nanoparticles as highly specialized therapeutics for achieving superior outcomes over standard pharmacological agents, the latter often associated with significant toxicity that limits treatment efficacy. While cancer immunothera…
Johannes Morstein · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $83,268 — Project Summary Significant progress in human cancer therapy in the last decade has been driven by conceptionally new approaches to targeting cancer, including cancer immunotherapy, cancer nanotherapy, or new types of biologics and small molecules. Both my dissertation and postdoc research will be f…
Aaron Clifford Brown · MAINEHEALTH · 2021 · $430,000 — Project Summary/Abstract The obesity epidemic is a global public health issue, that leads to an increased risk for type 2 diabetes and cardiovascular disease. Hypertrophy, inflammation, and excess lipid accumulation in white adipocytes within fat tissue are hallmarks of obesity that contribute to me…
WADIH ARAP · RBHS -CANCER INSTITUTE OF NEW JERSEY · 2021 · $642,358 — ABSTRACT Eight percent of patients diagnosed with prostate cancer progress to lethal metastatic disease. Development of resistance to androgen-deprivation therapy and eventually, to last line chemotherapeutics such as enzalutamide (ENZ), contribute to lethal, metastatic prostate cancer. While intere…
Zahi A. Fayad · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $815,005 — SUMMARY Atherosclerotic plaque regression as a result of lipid-lowering treatment has been limited at best, with coronary artery disease (CAD) related event rates remaining unacceptably high. In this application, we propose that targeted immunomodulation of macrophages will resolve plaque inflamma…
Amer Alam · UNIVERSITY OF MINNESOTA · 2021 · $435,750 — Project Summary Alzheimer’s disease (AD) represents one of the foremost healthcare challenges of our times and is a leading cause of death worldwide. AD accounts for the overwhelming majority of dementias, which affect over 35 million people worldwide. This number is expected to double every twenty …
Elliot Chaikof · BETH ISRAEL DEACONESS MEDICAL CENTER · 2021 · $711,044 — Project Summary New in vivo delivery technologies are urgently needed that enable selective genome editing of somatic cells without the limitations of existing viral delivery systems or lipid nanoparticles. We propose to develop two complementary strategies. First, by tethering Cas9 and base editor…
Jae K Lee · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2021 · $481,767 — PROJECT SUMMARY/ABSTRACT After spinal cord injury (SCI), the injury site is filled with cellular debris, especially myelin debris that creates a very unique lipid-dense environment. Macrophages are the predominant phagocyte that are responsible for debris-clearance, but this process is not only inef…
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $486,326 — Abstract Aberrant lipoprotein metabolism is a hallmark of obesity that affects >40% of Americans. Obesity and its com- plications, including type-2 diabetes (T2D), cardiovascular, amyloid and severe viral diseases, are the leading causes of premature death. The ultimate goal of this research is to …
Karen N. Allen · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $451,334 — Complex glycoconjugates play a pivotal role in bacterial survival, colonization and virulence and contribute to the interactions between symbiotic and pathogenic bacteria and their human hosts. An important mechanism for the assembly of these structures is initiated on the cytoplasmic face of cell m…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2021 · $733,169 — Summary. Hemoglobinopathies such as β-thalassemia and sickle cell disease are genetic disorders caused by mutations in the HBB gene that codes for the β-globin component of hemoglobin. Currently, the only gene therapy available for these prevalent hereditary diseases is based on transplantation of g…
John B Barnett · EXESALIBERO, INC. · 2021 · $394,939 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
Jinjun Shi · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $711,340 — ABSTRACT With the ability to silence individual genes and to drug the ‘undruggable’, RNA interference (RNAi) therapy has recently shown clinical success by delivering small interfering RNA (siRNA) to the liver for genetic diseases. However, new delivery strategies will be needed to expand the target…