Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
VALERIE B GOUON-EVANS · BOSTON MEDICAL CENTER · 2021 · $536,021 — PROJECT SUMMARY Liver transplantation is currently the only treatment for acute and chronic liver failure. Given the shortage of donor livers, hepatocyte transplantation is considered a potential treatment for liver diseases and a bridge for patients awaiting liver transplantation, but its applicati…
Esma Alp · KALOCYTE, INC. · 2021 · $499,999 — Project Summary/Abstract ErythroMer (EM) is a novel biosynthetic blood substitute developed to address the critically unmet need for emergency transfusion in situations where the use of banked red blood cells (RBCs) are inaccessible or undesirable. EM is a self-assembled lipid-peptidic hybrid nanopa…
Bruce Shapiro · DIVISION OF BASIC SCIENCES - NCI · 2021 · $871,639 — Recently we developed a new type of RNA nanostructure that forms a truncated tetrahedron in collaboration with Luc Jaeger, UC Santa Barbara. The structure was built from our hexameric ring where 4 sides of the tetrahedral structure each contain the hexmeric ring, but each ring contains 3 H-shaped cr…
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2021 · $330,352 — The primary function of OMICS Core is to provide members of the University of Louisville Alcohol Research Center (ULARC) with the expertise, resources, and facilities needed for metabolomic, proteomic, and bioinformatic analyses of biological samples collected to study nutrition, gut flora/intestina…
Huan Xie · TEXAS SOUTHERN UNIVERSITY · 2021 · $224,138 — PROJECT SUMMARY Prostate cancer (PCa) is the second leading cause of cancer death in the United States among men and it is more common in African American males. Despite initial good responses to androgen deprivation or anti- androgen drugs, tumors invariably recur and develop into lethal castration…
Colby Shad Thaxton · NORTHWESTERN UNIVERSITY AT CHICAGO · 2021 · $398,137 — SUMMARY The overall goal of the Lipid-Based Self-Assembled Materials and Characterization Core (LBSAMCC) is to synthesize, characterize, and deliver highly novel therapeutics for ameliorating the devastating effects of nitrogen and sulfur mustards to the eye (Project 1) and skin (Project 2). High-de…
TIMOTHY M GRIFFIN · OKLAHOMA CITY VA MEDICAL CENTER · 2020 — Osteoarthritis (OA) disproportionately affects veterans, resulting in more pain and functional limitations compared to the general population. No disease-modifying treatments exist for OA, and current pain medications (e.g., opioids and NSAIDs) have limited long-term efficacy and adverse side effect…
John B Barnett · EXESALIBERO, INC. · 2020 · $108,153 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
Youzhong Guo · VIRGINIA COMMONWEALTH UNIVERSITY · 2020 · $182,288 — SUMMARY Membrane proteins play crucial roles in living organisms. Protein-lipid interactions are crucial for the structural and functional integrity of membrane proteins. High-resolution of membrane protein structures are in high-demand for both understanding their biology and structure-based drug d…
Gabor Csanyi · AUGUSTA UNIVERSITY · 2020 · $384,687 — Project Summary Atherosclerosis, the main underlying cause of death worldwide, is characterized by chronic inflammation and accumulation of lipids in the arterial wall. Excessive lipid accumulation by macrophages (MΦs) and vascular smooth muscle cells (SMCs) plays a key role in the initiation and pr…
Zahi A. Fayad · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $815,612 — SUMMARY Atherosclerotic plaque regression as a result of lipid-lowering treatment has been limited at best, with coronary artery disease (CAD) related event rates remaining unacceptably high. In this application, we propose that targeted immunomodulation of macrophages will resolve plaque inflamma…
Gretchen Mahler · STATE UNIVERSITY OF NY,BINGHAMTON · 2020 · $303,663 — PROJECT SUMMARY Nanomaterials are increasingly used in consumer products, processed food, and food packaging, and few studies have determined the consequences of nanoparticle ingestion. The ultimate goal of this work is to determine if and how ingested metal oxide nanoparticles alter microorganism p…
Sashwati Roy · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $393,750 — ABSTRACT Persistent unresolved inflammation impairs diabetic wound healing. The function and fate of wound monocyte/macrophages (mϕ) hold the key to the outcome of wound inflammation. This proposal builds on observations originating from live functional wound macrophages (wmϕ) and wound fluid derive…
Kevin V Morris · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2020 · $440,000 — Project Summary Targeted transcriptional activation of HIV Human Immunodeficiency Virus type 1 (HIV-1) is a lentivirus that causes a persistent viral infection that results in the demise of immune regulatory cells. Clearance of HIV-1 infection by the immune system is inefficient, and integration of …
Rajagopal Ramesh · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2020 · $306,308 — Effective control of lung cancer continues to remain a clinical challenge resulting in poor five-year survival rate. Currently available therapies while showing promise have had limitations. Therefore, continued efforts for developing new therapeutic agents and systemic treatment modalities are warr…
Gaurav Sahay · OREGON STATE UNIVERSITY · 2020 · $666,748 — ABSTRACT: Cystic fibrosis (CF) is conferred by any of ≥1200 known mutations in the gene encoding the CFTR, an ion transporter protein, but in principle, a single gene therapy agent that delivers expression of functional CFTR could treat. Prior attempts to do so have used adeno-associated viral or li…
Chad V Pecot · ENFUEGO THERAPEUTICS INC. · 2020 · $224,995 — Research Summary: The KRAS proto-oncogene is one of the most critical genes in cancer, yet it has also proven to be among the most elusive. Nearly all (98%) of KRAS missense mutations occur in codons 12 or 13, which leads to constitutive KRAS activation and promotion of numerous cancer hallmarks. Al…
James F. Collins · UNIVERSITY OF FLORIDA · 2020 · $511,395 — Project Summary Iron is an essential nutrient for humans, yet excess iron is toxic. As such, iron overload and iron deficiency result in severe homeostatic perturbations. Iron overload is most frequently associated with hereditary hemochromatosis (HH), which afflicts ~1:250 adults in the U.S. Tissue…
HUGO Ramon ROSEN · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $371,250 — PROJECT SUMMARY /ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, affecting at least a quarter of the world’s population, and therefore highly relevant to the NIH mission. From steatosis to fibrosis, hepatic inflammation drives disease progression…
Jinjun Shi · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $540,226 — DESCRIPTION (provided by applicant): Given the capability of modulating individual gene expression in tumor cells, RNA agents such as small interfering RNA (siRNA) and messenger RNA (mRNA) have demonstrated tremendous potential in revealing the functionality of specific gene alterations and ena…