Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Huang Chiao Huang · UNIV OF MARYLAND, COLLEGE PARK · 2020 · $202,977 — DESCRIPTION (provided by applicant): It is increasingly evident that rationally designed combination therapies impacting multiple targets will most likely to improve outcomes in patients with glioblastoma (GBM). However, the selective delivery of multiple regimens to the right place, at the right ti…
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2020 · $285,821 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…
AJAY NMN RANA · JESSE BROWN VA MEDICAL CENTER · 2020 — Project Summary/Abstract: The main focus of research in our group is to understand the underlying molecular mechanisms of pancreatic and breast cancer pathogenesis. The overarching goal of our research is to investigate how the cellular pathways (i.e. circuits) are dysregulated and can lead to uncon…
Sarah EV Richards · BROAD INSTITUTE, INC. · 2020 · $425,000 — Aging-related neurological diseases impact millions people worldwide, and this number is expected to increase drastically as the global average age continues to increase. While the need to develop new neuroprotective therapeutics has never been higher, our current efforts rely on only a partial unde…
Gregory J Dodge · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $65,310 — Abstract: This project aims to expand the mechanistic understanding of the initial membrane-associated steps of bacterial glycoconjugate biosynthesis. Membrane protein structures are critically underrepresented in the protein data bank (PDB), and remain difficult targets for purification, character…
JENNIFER A DOUDNA · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $781,190 — PROJECT SUMMARY / ABSTRACT CRISPR-Cas9 has demonstrated incredible potential to provide clinical benefit, but the challenge of delivery currently hinders therapeutic use of genome editing in vivo. Use of viral vectors and lipid nanoparticles has established the viability of in vivo genome editing, b…
Andrei Maiseyeu · CASE WESTERN RESERVE UNIVERSITY · 2020 · $396,250 — Project Summary Hyperglycemia is the hallmark of type 2 diabetes (T2D) and accelerates the development of atherosclerosis, which, in turn, precedes the development of major cardiovascular complications. In people with T2D, cardiovascular disease significantly contributes to mortality, accounting fo…
Daniel John Siegwart · UT SOUTHWESTERN MEDICAL CENTER · 2020 · $364,500 — Project Summary Co-delivery of Cas9 mRNA and targeted sgRNA is a promising strategy to achieve CRISPR/Cas gene editing in vivo with improved safety. Although great advances have been made in the delivery of short RNAs (siRNA, miRNA), the ideal chemical and formulation composition is largely unknown …
VALERIE B GOUON-EVANS · BOSTON MEDICAL CENTER · 2020 · $555,521 — PROJECT SUMMARY Liver transplantation is currently the only treatment for acute and chronic liver failure. Given the shortage of donor livers, hepatocyte transplantation is considered a potential treatment for liver diseases and a bridge for patients awaiting liver transplantation, but its applicati…
Ann Cornwall Collier · UNIVERSITY OF WASHINGTON · 2020 · $771,303 — The Targeted Long-acting Combination Antiretroviral Therapy (TLC-ART) Program has discovered a novel platform that can stabilize insoluble and soluble antiretroviral drugs together in a nanosuspension which provides long-acting (LA) plasma and cell concentrations in pre-clinical studies. The lead fo…
Juliane Nguyen · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $358,348 — PROJECT SUMMARY/ABSTRACT Exosomes were originally thought of as the cellular “waste-disposal system.” It is now known that they are important for intercellular communication and contribute to the pathogenesis of several diseases including cancer, neurodegenerative disease, and autoimmunity. Once sec…
CYRUS R SAFINYA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2020 · $197,966 — ABSTRACT (PUBLICLY RELEASABLE) The current level of research activity involving gene therapy with either synthetic vectors (carriers) or engineered viruses is unprecedented. Liposomes are the most widely studied nonviral carriers worldwide for nucleic acid (NA) and drug delivery applications. Catio…
Yifan Cheng · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $292,301 — As a versatile structure determination technology, cryo-EM is an integrated part of the HARC Center. In the past funding cycle, the Cryo-EM Core has engaged in technology development of single-particle cryo-EM, and has made major contributions to the recent technological breakthroughs in single part…
S. Munir ALAM · DUKE UNIVERSITY · 2020 · $468,316 — Induction of broadly neutralizing antibodies (bnAbs) is a critical unmet goal of HIV vaccine development. BnAb DH511 is of high interest as a vaccine lead due to its very high breadth and the high in vivo protective potency of MPER bNAbs. Key challenges for inducing DH511-like bnAbs are: (a) the low…
Joel Kaar · UNIVERSITY OF COLORADO · 2020 · $178,987 — SUMMARY The formation of amyloid fibrils due to protein aggregation represents a central step in the pathogenesis of many age-related diseases for which there are no current cures. At the core of this step is the misfolding of one or more key proteins, which is converted from a natively folded or un…
Rebecca Long Heise · VIRGINIA COMMONWEALTH UNIVERSITY · 2020 · $217,379 — Acute Respiratory Distress Syndrome (ARDS) is diagnosed in 150,000 patients per year in the United States. These types of lung injury may be caused by severe infection, inhaling dangerous substances, or trauma. ARDS has a high impact on mortality with approximately half of all people diagnosed dying…
Lbachir BenMohamed · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $210,375 — PROJECT SUMMARY/ABSTRACT A staggering number of individuals—over 3 billion worldwide—are currently infected with herpes simplex virus type 1 (HSV-1), which causes frequent, and often lifelong, bouts of recurrent corneal herpetic disease. This potentially blinding disease is a result of corneal re-i…
BABU L TEKWANI · SOUTHERN RESEARCH INSTITUTE · 2020 · $728,482 — PROJECT SUMMARY/ABSTRACT Development of dormant hypnozoites in the hepatic tissues, which may cause malaria relapse weeks to months after the initial infection, poses the major challenge for treatment & control of vivax malaria. 8- Aminoquinolines (8-AQs) are the only antimalarial drugs active agai…
NIGEL W BUNNETT · NEW YORK UNIVERSITY · 2020 · $282,990 — PROJECT SUMMARY This proposal examines the mechanisms by which G protein-coupled receptors (GPCRs) signal pain. Chronic pain is a hallmark of disease, a side effect of therapy, and a major cause of suffering. Although GPCRs mediate all aspects of nociception and are major therapeutic targets, the me…
WADIH ARAP · RBHS -CANCER INSTITUTE OF NEW JERSEY · 2020 · $642,804 — ABSTRACT Eight percent of patients diagnosed with prostate cancer progress to lethal metastatic disease. Development of resistance to androgen-deprivation therapy and eventually, to last line chemotherapeutics such as enzalutamide (ENZ), contribute to lethal, metastatic prostate cancer. While intere…