Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Forrest M Kievit · UNIVERSITY OF NEBRASKA LINCOLN · 2020 · $445,684 — PROJECT SUMMARY/ABSTRACT Traumatic brain injury (TBI) is the leading cause of disability and death in people under 45 with approximately 10 million new cases each year worldwide. The effects of TBI can be severe, including neurocognitive, physical, and psychosocial impairment. There remains a signi…
Clyde Jason Wright · UNIVERSITY OF COLORADO DENVER · 2020 · $490,696 — PROJECT SUMMARY Bronchopulmonary dysplasia (BPD) is the most common morbidity complicating preterm birth and predicts poor pulmonary and neurodevelopmental outcomes. Despite the well-documented association between inflammation and BPD, no safe and effective anti-inflammatory therapies to prevent BP…
Brian H. Johnston · SOMAGENICS, INC. · 2020 · $965,488 — Abstract Hepatitis D virus (HDV) infection is the most severe type of viral hepatitis, often causing accelerated liver damage that leads to end-stage liver disease. About 15–20 million individuals are infected by HDV worldwide. The absence of an effective treatment for acute forms of the disease and…
Suchismita Acharya · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · 2020 · $365,000 — Glaucoma is a neurodegenerative disease of the eye with an estimated prevalence of 80 million patients worldwide by 2020, at least 6 to 8 million becoming bilaterally blind. Elevated intraocular pressure (IOP) causing axonal degeneration of the optic nerve and progressive loss of retinal ganglion ce…
Zheng-Yi Chen · MASSACHUSETTS EYE AND EAR INFIRMARY · 2020 · $782,510 — Project Summary and Relevance Application of genome editing based therapy requires efficient delivery of editing agents into disease-relevant tissues and cells. Identification of novel delivery materials targeting somatic cells will greatly facilitate the advance of editing based therapy strategies …
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2020 · $427,652 — PROJECT SUMMARY / ABSTRACT The overall goal of this grant has been to understand in molecular details the action of apolipoproteins (apos) and lipoproteins in health and disease. The current focus is on human apoA-I, the major protein of plasma high-density lipoproteins (HDL, a.k.a. good cholesterol…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2020 · $370,620 — Project Summary Scientists can create thousands of chemically distinct nanoparticles using a growing number of high throughput chemistries, but it is still difficult to test more than a few nanoparticles in vivo. The goal of this work is to substantially improve how lipid nanoparticles (LNPs) delive…
Robert F Place · MIRECULE, INC. · 2020 · $1,000,000 — Abstract: In this phase 2 SBIR application, miRecule proposes to develop a microRNA-based therapeutic mimic of miR- 30-5p (miRecule candidate MC-30) for the treatment of multi-drug resistant (MDR) cancers. Head and Neck Squamous Cell Carcinoma (HNSCC) is the 6th most common form of cancer. Greater t…
John Ramunas · REJUVENATION TECHNOLOGIES, INC. · 2020 · $272,403 — Abstract Rejuvenation Technologies Inc. (RTI) aims to prevent liver fibrosis in alcoholic hepatitis (AH) by enhancing liver regenerative capacity. AH is an acute form of alcoholic liver disease with mortality of up to 50% within 1 month of presentation. Most AH patients exhibit advanced fibrosis/cir…
ZHENG-RONG LU · CASE WESTERN RESERVE UNIVERSITY · 2020 · $356,947 — The goal of this project is to develop smart dual-targeted lipid ECO/siRNA self-assembly nanoparticles to target oncogenic long non-coding RNAs (lncRNAs) as a novel therapy to treat metastatic and drug-resistant triple negative breast cancer (TNBC). Metastasis and drug resistance are the main causes…
Bryce C Chackerian · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $513,123 — PROJECT SUMMARY Over 30% of the adult population of the United States has elevated levels of low-density lipoprotein cholesterol (LDL-C), a condition that is correlated with an increased risk of coronary heart disease and stroke. Lifestyle modifications and treatment with statins can be sufficient f…
Song Li · UNIVERSITY OF ILLINOIS AT CHICAGO · 2020 · $680,572 — The amplification of Estrogen, Progesterone and Human Epidermal Growth Factor receptors (i.e. ER, PR and HER2) serve as prognostic markers in breast cancer. The prognosis of ER+ breast cancer is relatively better due to availability of several drugs that essentially block ER-signaling. However, HER2…
William H. Peranteau · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $760,313 — PROJECT SUMMARY Metabolic liver diseases are the second most common indication for a pediatric liver transplant. Hereditary tyrosinemia type I (HT1) is a metabolic liver disease that results from FAH gene mutations causing a deficiency in fumarylacetoacetate hydrolase (FAH), the last enzyme in the t…
Michael Dennis Raleigh · WASHINGTON UNIVERSITY · 2020 · $180,011 — PROJECT SUMMARY. The goal of this CEBRA is to integrate cutting-edge concepts from nanotechnology, immunology, and addiction to develop nanovaccines to treat heroin and prescription opioid abuse and prevent fatal overdose. Opioid abuse is a major national emergency in the US with an enormous cost in…
Elena Aikawa · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $661,115 — Project Summary This research project will test the hypothesis that, in the diabetic milieu, S100A9 induces the calcification potential of macrophage-derived extracellular vesicles (EV), precursors of microcalcifications, contributing to the biomechanical instability of the vulnerable atheroscleroti…
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2020 · $198,306 — PROJECT SUMMARY This proposal aims to develop live-cell, multi-channel imaging tools that can visualize—continuously, and in real time—nanoparticle interactions with cellular components. We will focus on several different time windows, where early time periods will monitor nanoparticle-cell membran…
John B Barnett · EXESALIBERO, INC. · 2020 · $1,103,697 — We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic.…
Gary Liu · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $64,926 — PROJECT SUMMARY/ABSTRACT Vascular injury and disease during diabetes lead to end-organ dysfunction (kidney failure, blindness, amputation) and cardiovascular disease that profoundly reduces patient quality of life and life expectancy. The proposed work seeks to develop new therapeutics to prevent an…
Ariana Kathryn von Lersner · VANDERBILT UNIVERSITY · 2020 · $30,238 — PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogenous group of lipid bilayer enclosed particles secreted from cells and are found in most, if not all, biological fluids. The term EV encompasses a wide range of vesicle classes, including exosomes (50-150 nm) and microvesicles (150 nm - 100…
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2020 · $38,000 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…