Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
YONG ZHU · YALE UNIVERSITY · 2020 · $218,588 — Abstract The goal of the proposed study is to demonstrate the viability of a novel Piwi-interacting RNA (piRNA)-based therapeutic strategy for the treatment of hepatocellular carcinoma (HCC). piRNAs are an abundant class of small (26-31 nt) non-coding RNAs with approximately 23,000 known human membe…
SEBASTIAN JOYCE · VETERANS HEALTH ADMINISTRATION · 2020 — The overarching goal of my research program is to understand the molecular mechanisms of immune surveillance mediated by tissue-resident memory T cells that patrol the mucosal barrier of the lungs to control infectious diseases and cancers. My laboratory is best recognized for its c…
Sangpil Yoon · UNIVERSITY OF NOTRE DAME · 2020 · $249,000 — Project Summary / Abstract Dr. Sangpil Yoon is a postdoctoral scholar at the Department of Biomedical Engineering at the University of Southern California (USC). He has developed an innovative technique for the intracellular delivery of macromolecules using high frequency ultrasound. Dr. Yoon is a p…
SonBinh TheBao Nguyen · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $197,500 — PROJECT SUMMARY Cholesterol has been linked to several cardiac and brain vascular diseases, dementias, diabetes, and cancer. Emerging data suggests that such diseases can be traced back to an imbalance in cholesterol transport mediated by high-density lipoproteins (HDLs), specifically attributed to …
DREW WEISSMAN · UNIVERSITY OF PENNSYLVANIA · 2020 · $636,665 — Project Summary Hemophilia is a genetic disorder defined by either an inadequate supply or an inactive blood clotting factor. The two most common forms are hemophilia A and B, caused by genetic defects in clotting factors VIII and IX, respectively. Both are X-linked recessive disorders characterize…
Amaia Lujambio · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $634,298 — Chronic liver disease and its common sequela cirrhosis, are growing public health concerns, and major risk factors for the development of hepatocellular cancer (HCC). HCC incidence and mortality is growing in the USA. Optimal medical therapies for HCC are lacking. FDA approved agents are modestly ef…
MICHAEL B ELOWITZ · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2020 · $602,432 — Cell targeting with synthetic sense-and-respond protease circuits Abstract A fundamental challenge in biomedicine is developing therapeutics that can target specific cell populations. Synthetic protein circuits, based on engineered proteins that interact with one another and with endogenous cellular…
Elliot Chaikof · BETH ISRAEL DEACONESS MEDICAL CENTER · 2020 · $752,780 — Project Summary New in vivo delivery technologies are urgently needed that enable selective genome editing of somatic cells without the limitations of existing viral delivery systems or lipid nanoparticles. We propose to develop two complementary strategies. First, by tethering Cas9 and base editor…
Reyad A Elbarbary · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2020 · $395,785 — Abstract Impaired or delayed fracture healing is a clinical problem that affects >1.5 million people in the US annually; obesity and associated type 2 diabetes (T2D) are significant and independent risk factors in this context. Nearly 34% of the US population is obese, and the number is projected to…
ASMA NUSRAT · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $460,345 — Abstract The gastrointestinal epithelium plays a central role in maintaining and coordinating mucosal homeostasis and immunity. Intestinal epithelial barrier compromise in mucosal wounds is seen in many pathologic states that encompass inflammatory bowel diseases, ischemia, mechanical injury and sur…
Elizabeth A Nance · UNIVERSITY OF WASHINGTON · 2020 · $183,558 — PROJECT SUMMARY/ABSTRACT Perinatal asphyxia (PA), where newborn infants suffer from a lack of oxygen and blood flow to the brain, is a leading cause of morbidity and mortality around the time of birth. PA in term infants, and the resulting neurodevelopmental sequelae such as intellectual disability,…
Evan Alexander Scott · NORTHWESTERN UNIVERSITY · 2020 · $685,339 — PROJECT SUMMARY Subunit vaccines combine immunodominant protein or peptide antigens from pathogens with select adjuvants, aiming to provide a more scalable, reproducible, low cost and rapid alternative to attenuated vaccines that contain live pathogens. Unfortunately, current subunit vaccines lack …
Jin Xie · UNIVERSITY OF GEORGIA · 2020 · $471,199 — Abstract Photodynamic therapy (PDT) has gained much attention as a relatively new cancer treatment modality. PDT has a favorable toxicity profile compared to radiotherapy. Meanwhile, it does not incur resistance, and can be applied to previously irradiated tissues. However, the use of PDT in the cl…
Mary Jane Thomassen · EAST CAROLINA UNIVERSITY · 2020 · $311,261 — DESCRIPTION (provided by applicant): Pulmonary granuloma formation is a key feature of sarcoidosis, a chronic disease of unknown etiology. Sarcoidosis has been linked to environmental risk factors (wood-burning stoves, fireplaces and firefighting) that favor carbon nanotube formation. We have shown …
Youzhong Guo · VIRGINIA COMMONWEALTH UNIVERSITY · 2020 · $382,600 — SUMMARY Membrane proteins play crucial roles in living organisms. Protein-lipid interactions are crucial for the structural and functional integrity of membrane proteins. High-resolution of membrane protein structures are in high-demand for both understanding their biology and structure-based drug d…
Martina Ralle · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $189,857 — Project Summary X-ray fluorescence microscopy (XFM) has emerged as powerful tool to visualize metals within cells or tissue. Using X-ray microprobes, investigators can now produce elemental maps of biological material at the cellular and subcellular levels. Determining the elemental distribution and…
GREGORY C GIBSON · GEORGIA INSTITUTE OF TECHNOLOGY · 2020 · $173,912 — Project Summary Over the past decade, the NIDDK IBDGC (Inflammatory Bowel Disease Genetics Consortium) has generated extraordinary datasets in support of genetic analysis of the onset, progression, and therapeutic response to Crohn's disease and ulcerative colitis. This Ancillary project will comple…
Michelle S Bradbury · SLOAN-KETTERING INST CAN RESEARCH · 2020 · $658,454 — Project Summary: Enormous strides continue to be made in the design of nanoparticles as highly specialized therapeutics for achieving superior outcomes over standard pharmacological agents, the latter often associated with significant toxicity that limits treatment efficacy. While cancer immunothera…
Song Hong · LSU HEALTH SCIENCES CENTER · 2020 · $381,265 — ABSTRACT We are applying for a 1-year supplemental award in response to NIH Notice NOT-AG-20-008 “AD/ADRD- focused supplements for NIH grants that are not focused on AD/ADRD.” The goal of the parent project of this supplement is to develop pro-resolving reparative maresin-like lipid mediators encaps…
Maria Lambros · DORICPHARMA LLC · 2020 · $102,195 — PROJECT SUMMARY/ABSTRACT Pancreatic cancer continues to be a devastating disease with less than 10% 5-year survival. Pancreatic cancer is aggressive and there are no good tools for early detection. By the time of diagnosis, the tumor is often surgically unresectable. At this stage, patients are ofte…