Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
SonBinh TheBao Nguyen · NORTHWESTERN UNIVERSITY AT CHICAGO · 2019 · $237,000 — PROJECT SUMMARY Cholesterol has been linked to several cardiac and brain vascular diseases, dementias, diabetes, and cancer. Emerging data suggests that such diseases can be traced back to an imbalance in cholesterol transport mediated by high-density lipoproteins (HDLs), specifically attributed to …
Zheng-Yi Chen · MASSACHUSETTS EYE AND EAR INFIRMARY · 2019 · $789,370 — Project Summary and Relevance Application of genome editing based therapy requires efficient delivery of editing agents into disease-relevant tissues and cells. Identification of novel delivery materials targeting somatic cells will greatly facilitate the advance of editing based therapy strategies …
Marco Pravetoni · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2019 · $1,537,430 — Project Summary Opioid use disorders (OUD) are a national public health emergency with more than 115 fatal overdoses occurring each day in the USA. Annually, the economic burden of OUD is over US$78 billion. Several medications are available for treating OUD, but their access is limited and efficacy…
Sashwati Roy · INDIANA UNIVERSITY INDIANAPOLIS · 2019 · $393,750 — ABSTRACT Persistent unresolved inflammation impairs diabetic wound healing. The function and fate of wound monocyte/macrophages (mϕ) hold the key to the outcome of wound inflammation. This proposal builds on observations originating from live functional wound macrophages (wmϕ) and wound fluid derive…
Pranoti Mandrekar · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2019 · $376,875 — DESCRIPTION (provided by applicant): Activation of liver resident macrophages and increased pro-inflammatory cytokine production is a hallmark in the pathogenesis of alcoholic liver disease (ALD). Alcohol-induced oxidative stress plays an important role in macrophage activation. Stress induced …
MICHAEL P CZECH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2019 · $582,900 — Abstract The overarching long term goal of our laboratory is to understand and exploit how adipose tissues exert powerful control over whole body glucose tolerance and insulin sensitivity. Small amounts of mouse brown (BAT) or human “Beige” adipocytes transplanted into recipient mice can improve glu…
Joshua A Kritzer · TUFTS UNIVERSITY MEDFORD · 2019 · $286,228 — Cell Penetration Profiling for Biotherapeutics Biotechnology promises the ability to control biology and disease with laser-like precision. Hundreds of peptides, proteins and nucleic acids are being developed as diagnostics and therapies, but nearly all of these have poor cell penetration and unpred…
Masanori Aikawa · BRIGHAM AND WOMEN'S HOSPITAL · 2019 · $602,965 — DESCRIPTION (provided by applicant): Uncontrolled activation of macrophages promotes various inflammatory diseases. The most devastating diseases linked to macrophage activation include atherosclerosis, a global health burden. To discover novel regulators of macrophage activation as therapeutic…
Dana Ashley Hill · CHILDREN'S RESEARCH INSTITUTE · 2019 · $395,349 — DESCRIPTION (provided by applicant): Studies of inherited cancer syndromes have provided unique opportunities to uncover and explain important cellular pathways with broad relevance to both sporadic cancers and human development. This proposal studies the cancer predisposition syndrome original…
SEBASTIAN JOYCE · VETERANS HEALTH ADMINISTRATION · 2019 — The overarching goal of my research program is to understand the molecular mechanisms of immune surveillance mediated by tissue-resident memory T cells that patrol the mucosal barrier of the lungs to control infectious diseases and cancers. My laboratory is best recognized for its c…
JAMES K TSURUTA · UNIV OF NORTH CAROLINA CHAPEL HILL · 2019 · $76,258 — ABSTRACT Lipid shelled perfluorocarbon (PFC) microbubbles ranging from 0.5 to 8 microns in diameter have been approved by the FDA to enhance the contrast of blood for diagnostic ultrasound imaging. The micro scale of ultrasound contrast agents limits them to the bloodstream, eliminating the enhanced…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2019 · $365,759 — Project Summary Scientists can create thousands of chemically distinct nanoparticles using a growing number of high throughput chemistries, but it is still difficult to test more than a few nanoparticles in vivo. The goal of this work is to substantially improve how lipid nanoparticles (LNPs) delive…
Rebecca Long Heise · VIRGINIA COMMONWEALTH UNIVERSITY · 2019 · $181,005 — Acute Respiratory Distress Syndrome (ARDS) is diagnosed in 150,000 patients per year in the United States. These types of lung injury may be caused by severe infection, inhaling dangerous substances, or trauma. ARDS has a high impact on mortality with approximately half of all people diagnosed dying…
Jay Reddy · UNIVERSITY OF NEBRASKA LINCOLN · 2019 · $219,708 — PROJECT SUMMARY/ABSTRACT An estimated 33% of American adults (85.6 million) have some form of cardiovascular disease, with a projected incidence of 43.9% by 2030. Despite heart disease's status as the leading cause of death in humans, there remains a significant gap in our knowledge of its pathogene…
Brian H. Johnston · SOMAGENICS, INC. · 2019 · $1,000,000 — Abstract Hepatitis D virus (HDV) infection is the most severe type of viral hepatitis, often causing accelerated liver damage that leads to end-stage liver disease. About 15–20 million individuals are infected by HDV worldwide. The absence of an effective treatment for acute forms of the disease and…
Gabor Csanyi · AUGUSTA UNIVERSITY · 2019 · $381,250 — Project Summary Atherosclerosis, the main underlying cause of death worldwide, is characterized by chronic inflammation and accumulation of lipids in the arterial wall. Excessive lipid accumulation by macrophages (MΦs) and vascular smooth muscle cells (SMCs) plays a key role in the initiation and pr…
Song Li · UNIVERSITY OF ILLINOIS AT CHICAGO · 2019 · $678,715 — The amplification of Estrogen, Progesterone and Human Epidermal Growth Factor receptors (i.e. ER, PR and HER2) serve as prognostic markers in breast cancer. The prognosis of ER+ breast cancer is relatively better due to availability of several drugs that essentially block ER-signaling. However, HER2…
Rajagopal Ramesh · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2019 · $317,518 — Effective control of lung cancer continues to remain a clinical challenge resulting in poor five-year survival rate. Currently available therapies while showing promise have had limitations. Therefore, continued efforts for developing new therapeutic agents and systemic treatment modalities are warr…
Bryce C Chackerian · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2019 · $580,797 — PROJECT SUMMARY Over 30% of the adult population of the United States has elevated levels of low-density lipoprotein cholesterol (LDL-C), a condition that is correlated with an increased risk of coronary heart disease and stroke. Lifestyle modifications and treatment with statins can be sufficient f…
Bhama Ramkhelawon · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2019 · $240,854 — Dr. Bhama Ramkhelawon nourishes 2 career goals during this award. An immediate goal to gain knowledge into the expression of the neuronal guidance cue, Netrin-1 in macrophage-elicited inflammation in Abdominal Aortic Aneurysms (AAAs) and a long-term career goal to become an independent investigator …